6PD2
PntC-AEPT: fusion protein of phosphonate-specific cytidylyltransferase and 2-aminoethylphosphonate (AEP) transaminase from Treponema denticola in complex with cytidine monophosphate-AEP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008483 | molecular_function | transaminase activity |
A | 0016779 | molecular_function | nucleotidyltransferase activity |
A | 0019700 | biological_process | organic phosphonate catabolic process |
A | 0032923 | biological_process | organic phosphonate biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
B | 0008483 | molecular_function | transaminase activity |
B | 0016779 | molecular_function | nucleotidyltransferase activity |
B | 0019700 | biological_process | organic phosphonate catabolic process |
B | 0032923 | biological_process | organic phosphonate biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
C | 0008483 | molecular_function | transaminase activity |
C | 0016779 | molecular_function | nucleotidyltransferase activity |
C | 0019700 | biological_process | organic phosphonate catabolic process |
C | 0032923 | biological_process | organic phosphonate biosynthetic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
D | 0008483 | molecular_function | transaminase activity |
D | 0016779 | molecular_function | nucleotidyltransferase activity |
D | 0019700 | biological_process | organic phosphonate catabolic process |
D | 0032923 | biological_process | organic phosphonate biosynthetic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue PLP A 701 |
Chain | Residue |
A | SER313 |
A | LYS441 |
A | PO4704 |
A | HOH883 |
A | HOH988 |
C | PHE489 |
C | THR490 |
A | GLY314 |
A | THR315 |
A | TYR340 |
A | HIS388 |
A | THR390 |
A | ASP415 |
A | VAL417 |
A | SER418 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MG A 702 |
Chain | Residue |
A | ASP106 |
A | GLU220 |
A | ASP222 |
A | MG703 |
A | 0RC705 |
A | HOH814 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MG A 703 |
Chain | Residue |
A | ASP136 |
A | GLU220 |
A | ASP222 |
A | MG702 |
A | 0RC705 |
A | HOH879 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue PO4 A 704 |
Chain | Residue |
A | TYR340 |
A | TYR575 |
A | PLP701 |
A | HOH822 |
A | HOH832 |
A | HOH988 |
A | HOH1006 |
C | ARG276 |
site_id | AC5 |
Number of Residues | 27 |
Details | binding site for residue 0RC A 705 |
Chain | Residue |
A | LEU8 |
A | ALA9 |
A | GLY10 |
A | GLY11 |
A | ARG15 |
A | LYS25 |
A | TYR80 |
A | THR83 |
A | GLY84 |
A | SER85 |
A | THR88 |
A | GLU104 |
A | SER105 |
A | ASP106 |
A | ASP136 |
A | LYS153 |
A | GLU196 |
A | GLU220 |
A | ASP222 |
A | MG702 |
A | MG703 |
A | ACT715 |
A | EDO717 |
A | HOH814 |
A | HOH828 |
A | HOH879 |
A | HOH1004 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue EDO A 706 |
Chain | Residue |
A | PHE310 |
A | GLY311 |
A | TYR471 |
A | GLN477 |
A | THR487 |
A | PHE489 |
A | HOH848 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ACT A 707 |
Chain | Residue |
A | ARG276 |
A | HOH824 |
C | TYR575 |
C | PRO576 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue EDO A 708 |
Chain | Residue |
A | GLN285 |
A | GLU306 |
A | THR307 |
A | EDO709 |
A | HOH874 |
A | HOH888 |
A | HOH949 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue EDO A 709 |
Chain | Residue |
A | CYS288 |
A | THR307 |
A | VAL308 |
A | TYR478 |
A | PHE481 |
A | ALA482 |
A | EDO708 |
A | EDO710 |
A | HOH888 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue EDO A 710 |
Chain | Residue |
A | CYS288 |
A | VAL308 |
A | MET309 |
A | GLN477 |
A | PHE481 |
A | THR487 |
A | EDO709 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue EDO A 711 |
Chain | Residue |
A | THR74 |
A | HOH1113 |
A | THR55 |
A | ASN59 |
A | ASP63 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue EDO A 712 |
Chain | Residue |
A | ARG249 |
A | THR261 |
A | ASP262 |
A | HOH846 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue EDO A 713 |
Chain | Residue |
A | LEU293 |
A | PHE294 |
A | LEU296 |
A | PRO424 |
A | MET425 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue EDO A 714 |
Chain | Residue |
A | TYR465 |
A | MET467 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue ACT A 715 |
Chain | Residue |
A | GLY13 |
A | SER14 |
A | ARG15 |
A | 0RC705 |
A | HOH1004 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue EDO A 716 |
Chain | Residue |
A | VAL417 |
A | TYR420 |
A | SER437 |
A | THR438 |
A | LYS441 |
A | ASN442 |
A | ILE443 |
site_id | AD8 |
Number of Residues | 9 |
Details | binding site for residue EDO A 717 |
Chain | Residue |
A | ASP136 |
A | GLU137 |
A | VAL138 |
A | LEU165 |
A | GLU220 |
A | 0RC705 |
A | HOH807 |
A | HOH844 |
A | HOH879 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 718 |
Chain | Residue |
A | PRO553 |
A | THR555 |
A | PRO556 |
A | TYR558 |
A | HOH840 |
A | HOH1039 |
site_id | AE1 |
Number of Residues | 16 |
Details | binding site for residue PLP B 701 |
Chain | Residue |
B | SER313 |
B | GLY314 |
B | THR315 |
B | TYR340 |
B | HIS388 |
B | THR390 |
B | ASP415 |
B | VAL417 |
B | SER418 |
B | LYS441 |
B | PO4704 |
B | HOH852 |
B | HOH927 |
B | HOH980 |
D | PHE489 |
D | THR490 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue MG B 702 |
Chain | Residue |
B | ASP106 |
B | GLU220 |
B | ASP222 |
B | MG703 |
B | 0RC705 |
B | HOH819 |
site_id | AE3 |
Number of Residues | 6 |
Details | binding site for residue MG B 703 |
Chain | Residue |
B | ASP136 |
B | GLU220 |
B | ASP222 |
B | MG702 |
B | 0RC705 |
B | HOH823 |
site_id | AE4 |
Number of Residues | 10 |
Details | binding site for residue PO4 B 704 |
Chain | Residue |
B | TYR340 |
B | TYR575 |
B | PLP701 |
B | HOH860 |
B | HOH899 |
B | HOH980 |
B | HOH1041 |
D | ARG276 |
D | THR490 |
D | HOH974 |
site_id | AE5 |
Number of Residues | 27 |
Details | binding site for residue 0RC B 705 |
Chain | Residue |
B | LEU8 |
B | ALA9 |
B | GLY10 |
B | GLY11 |
B | ARG15 |
B | LYS25 |
B | TYR80 |
B | THR83 |
B | GLY84 |
B | SER85 |
B | THR88 |
B | GLU104 |
B | SER105 |
B | ASP106 |
B | ASP136 |
B | VAL138 |
B | LYS153 |
B | LEU165 |
B | GLU196 |
B | GLU220 |
B | ASP222 |
B | MG702 |
B | MG703 |
B | PO4708 |
B | HOH819 |
B | HOH823 |
B | HOH1092 |
site_id | AE6 |
Number of Residues | 8 |
Details | binding site for residue EDO B 706 |
Chain | Residue |
B | ASP272 |
B | ILE273 |
B | VAL493 |
B | GLN494 |
D | PRO257 |
D | ALA258 |
D | THR260 |
D | HOH1034 |
site_id | AE7 |
Number of Residues | 6 |
Details | binding site for residue EDO B 707 |
Chain | Residue |
B | CYS288 |
B | VAL308 |
B | MET309 |
B | GLN477 |
B | THR487 |
B | HOH1021 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue PO4 B 708 |
Chain | Residue |
B | GLY13 |
B | SER14 |
B | ARG15 |
B | 0RC705 |
B | HOH896 |
site_id | AE9 |
Number of Residues | 6 |
Details | binding site for residue GOL B 709 |
Chain | Residue |
B | ASP289 |
B | LYS292 |
B | ASP303 |
B | GLU306 |
B | HOH979 |
B | HOH1051 |
site_id | AF1 |
Number of Residues | 7 |
Details | binding site for residue EDO B 710 |
Chain | Residue |
B | ARG276 |
B | HOH929 |
B | HOH942 |
B | HOH977 |
B | HOH1078 |
D | HIS564 |
D | PRO576 |
site_id | AF2 |
Number of Residues | 10 |
Details | binding site for residue GOL B 711 |
Chain | Residue |
B | PHE310 |
B | GLY311 |
B | TYR471 |
B | GLN477 |
B | THR487 |
B | ARG488 |
B | PHE489 |
B | THR490 |
B | PRO491 |
B | HOH978 |
site_id | AF3 |
Number of Residues | 7 |
Details | binding site for residue PO4 B 712 |
Chain | Residue |
B | PRO553 |
B | THR555 |
B | TYR558 |
B | HOH801 |
B | HOH812 |
B | HOH835 |
B | HOH1049 |
site_id | AF4 |
Number of Residues | 4 |
Details | binding site for residue ACT C 2201 |
Chain | Residue |
A | PRO576 |
C | ARG276 |
C | HOH2353 |
C | HOH2542 |
site_id | AF5 |
Number of Residues | 14 |
Details | binding site for residue PLP C 2202 |
Chain | Residue |
A | PHE489 |
A | THR490 |
C | SER313 |
C | GLY314 |
C | THR315 |
C | TYR340 |
C | HIS388 |
C | THR390 |
C | ASP415 |
C | SER418 |
C | PO42204 |
C | HOH2378 |
C | HOH2480 |
C | HOH2488 |
site_id | AF6 |
Number of Residues | 6 |
Details | binding site for residue MG C 2203 |
Chain | Residue |
C | ASP136 |
C | GLU220 |
C | ASP222 |
C | 0RC2205 |
C | MG2211 |
C | HOH2345 |
site_id | AF7 |
Number of Residues | 10 |
Details | binding site for residue PO4 C 2204 |
Chain | Residue |
A | ARG276 |
A | THR490 |
C | TYR340 |
C | TYR575 |
C | PLP2202 |
C | HOH2334 |
C | HOH2399 |
C | HOH2427 |
C | HOH2480 |
C | HOH2578 |
site_id | AF8 |
Number of Residues | 28 |
Details | binding site for residue 0RC C 2205 |
Chain | Residue |
C | LEU8 |
C | ALA9 |
C | GLY10 |
C | GLY11 |
C | ARG15 |
C | LYS25 |
C | TYR80 |
C | THR83 |
C | GLY84 |
C | SER85 |
C | THR88 |
C | GLU104 |
C | SER105 |
C | ASP106 |
C | ASP136 |
C | LYS153 |
C | LEU165 |
C | GLU196 |
C | GLU220 |
C | ASP222 |
C | MG2203 |
C | PO42207 |
C | MG2211 |
C | HOH2326 |
C | HOH2345 |
C | HOH2361 |
C | HOH2432 |
C | HOH2529 |
site_id | AF9 |
Number of Residues | 9 |
Details | binding site for residue EDO C 2206 |
Chain | Residue |
A | ASN241 |
A | HOH862 |
C | ASP110 |
C | TYR215 |
C | PHE216 |
C | VAL217 |
C | ASN241 |
C | HOH2341 |
C | HOH2552 |
site_id | AG1 |
Number of Residues | 6 |
Details | binding site for residue PO4 C 2207 |
Chain | Residue |
C | GLY13 |
C | SER14 |
C | ARG15 |
C | 0RC2205 |
C | HOH2432 |
C | HOH2527 |
site_id | AG2 |
Number of Residues | 8 |
Details | binding site for residue EDO C 2208 |
Chain | Residue |
C | TYR305 |
C | LYS406 |
C | LEU427 |
C | GLY431 |
C | ILE432 |
C | ASP433 |
C | ASN455 |
C | HOH2501 |
site_id | AG3 |
Number of Residues | 6 |
Details | binding site for residue EDO C 2209 |
Chain | Residue |
C | SER360 |
C | SER361 |
C | HOH2315 |
C | HOH2448 |
D | LYS463 |
D | TYR465 |
site_id | AG4 |
Number of Residues | 4 |
Details | binding site for residue EDO C 2210 |
Chain | Residue |
C | LYS346 |
C | ASP349 |
C | ILE350 |
C | HOH2303 |
site_id | AG5 |
Number of Residues | 6 |
Details | binding site for residue MG C 2211 |
Chain | Residue |
C | ASP106 |
C | GLU220 |
C | ASP222 |
C | MG2203 |
C | 0RC2205 |
C | HOH2326 |
site_id | AG6 |
Number of Residues | 7 |
Details | binding site for residue EDO C 2212 |
Chain | Residue |
C | PHE310 |
C | GLY311 |
C | TYR471 |
C | GLN477 |
C | THR487 |
C | PHE489 |
C | HOH2374 |
site_id | AG7 |
Number of Residues | 6 |
Details | binding site for residue EDO C 2213 |
Chain | Residue |
C | GLN285 |
C | GLU306 |
C | THR307 |
C | HOH2376 |
C | HOH2545 |
C | HOH2629 |
site_id | AG8 |
Number of Residues | 7 |
Details | binding site for residue EDO C 2214 |
Chain | Residue |
C | CYS288 |
C | VAL308 |
C | MET309 |
C | GLN477 |
C | PHE481 |
C | THR487 |
C | HOH2350 |
site_id | AG9 |
Number of Residues | 8 |
Details | binding site for residue PO4 C 2215 |
Chain | Residue |
C | PRO553 |
C | GLU554 |
C | THR555 |
C | PRO556 |
C | TYR558 |
C | HOH2313 |
C | HOH2331 |
C | HOH2335 |
site_id | AH1 |
Number of Residues | 6 |
Details | binding site for residue MG D 701 |
Chain | Residue |
D | ASP136 |
D | GLU220 |
D | ASP222 |
D | MG703 |
D | 0RC705 |
D | HOH841 |
site_id | AH2 |
Number of Residues | 16 |
Details | binding site for residue PLP D 702 |
Chain | Residue |
B | PHE489 |
B | THR490 |
D | SER313 |
D | GLY314 |
D | THR315 |
D | TYR340 |
D | HIS388 |
D | THR390 |
D | ASP415 |
D | SER418 |
D | LYS441 |
D | PO4709 |
D | HOH801 |
D | HOH836 |
D | HOH915 |
D | HOH961 |
site_id | AH3 |
Number of Residues | 6 |
Details | binding site for residue MG D 703 |
Chain | Residue |
D | ASP106 |
D | GLU220 |
D | ASP222 |
D | MG701 |
D | 0RC705 |
D | HOH803 |
site_id | AH4 |
Number of Residues | 2 |
Details | binding site for residue PO4 D 704 |
Chain | Residue |
D | LEU12 |
D | 0RC705 |
site_id | AH5 |
Number of Residues | 26 |
Details | binding site for residue 0RC D 705 |
Chain | Residue |
D | LEU8 |
D | ALA9 |
D | GLY10 |
D | GLY11 |
D | LYS25 |
D | TYR80 |
D | THR83 |
D | GLY84 |
D | SER85 |
D | THR88 |
D | GLU104 |
D | SER105 |
D | ASP106 |
D | ASP136 |
D | VAL138 |
D | LYS153 |
D | LEU165 |
D | GLU196 |
D | GLU220 |
D | ASP222 |
D | MG701 |
D | MG703 |
D | PO4704 |
D | HOH803 |
D | HOH978 |
D | HOH1016 |
site_id | AH6 |
Number of Residues | 9 |
Details | binding site for residue EDO D 706 |
Chain | Residue |
D | SER323 |
D | VAL326 |
D | PRO327 |
D | TYR465 |
D | PRO466 |
D | ARG468 |
D | HOH857 |
D | HOH917 |
D | HOH981 |
site_id | AH7 |
Number of Residues | 4 |
Details | binding site for residue EDO D 707 |
Chain | Residue |
B | TYR266 |
D | HIS46 |
D | PHE115 |
D | ARG245 |
site_id | AH8 |
Number of Residues | 3 |
Details | binding site for residue EDO D 708 |
Chain | Residue |
D | ARG245 |
D | ASP262 |
D | TYR266 |
site_id | AH9 |
Number of Residues | 10 |
Details | binding site for residue PO4 D 709 |
Chain | Residue |
B | ARG276 |
D | TYR340 |
D | TYR575 |
D | PLP702 |
D | HOH801 |
D | HOH862 |
D | HOH904 |
D | HOH927 |
D | HOH933 |
D | HOH961 |
site_id | AI1 |
Number of Residues | 6 |
Details | binding site for residue EDO D 710 |
Chain | Residue |
D | GLN285 |
D | GLU306 |
D | THR307 |
D | HOH845 |
D | HOH954 |
D | HOH1027 |
site_id | AI2 |
Number of Residues | 5 |
Details | binding site for residue EDO D 711 |
Chain | Residue |
D | VAL308 |
D | MET309 |
D | GLN477 |
D | THR487 |
D | HOH950 |
site_id | AI3 |
Number of Residues | 7 |
Details | binding site for residue EDO D 712 |
Chain | Residue |
D | PHE310 |
D | GLY311 |
D | TYR471 |
D | GLN477 |
D | THR487 |
D | PHE489 |
D | HOH835 |
site_id | AI4 |
Number of Residues | 3 |
Details | binding site for residue EDO D 713 |
Chain | Residue |
B | PRO576 |
B | HOH843 |
D | ARG276 |
site_id | AI5 |
Number of Residues | 4 |
Details | binding site for residue PO4 D 714 |
Chain | Residue |
D | GLU554 |
D | THR555 |
D | TYR558 |
D | HOH802 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 80 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31420548, ECO:0007744|PDB:6PD2 |
Chain | Residue | Details |
A | LEU8 | |
A | ASP136 | |
A | LYS153 | |
A | GLU196 | |
A | GLU220 | |
A | ASP222 | |
A | SER313 | |
A | GLY314 | |
A | THR315 | |
A | THR390 | |
A | LYS441 | |
A | GLY10 | |
A | THR490 | |
B | LEU8 | |
B | GLY10 | |
B | GLY11 | |
B | LYS25 | |
B | THR83 | |
B | THR88 | |
B | GLU104 | |
B | SER105 | |
B | ASP106 | |
A | GLY11 | |
B | ASP136 | |
B | LYS153 | |
B | GLU196 | |
B | GLU220 | |
B | ASP222 | |
B | SER313 | |
B | GLY314 | |
B | THR315 | |
B | THR390 | |
B | LYS441 | |
A | LYS25 | |
B | THR490 | |
C | LEU8 | |
C | GLY10 | |
C | GLY11 | |
C | LYS25 | |
C | THR83 | |
C | THR88 | |
C | GLU104 | |
C | SER105 | |
C | ASP106 | |
A | THR83 | |
C | ASP136 | |
C | LYS153 | |
C | GLU196 | |
C | GLU220 | |
C | ASP222 | |
C | SER313 | |
C | GLY314 | |
C | THR315 | |
C | THR390 | |
C | LYS441 | |
A | THR88 | |
C | THR490 | |
D | LEU8 | |
D | GLY10 | |
D | GLY11 | |
D | LYS25 | |
D | THR83 | |
D | THR88 | |
D | GLU104 | |
D | SER105 | |
D | ASP106 | |
A | GLU104 | |
D | ASP136 | |
D | LYS153 | |
D | GLU196 | |
D | GLU220 | |
D | ASP222 | |
D | SER313 | |
D | GLY314 | |
D | THR315 | |
D | THR390 | |
D | LYS441 | |
A | SER105 | |
D | THR490 | |
A | ASP106 |