6PD2
PntC-AEPT: fusion protein of phosphonate-specific cytidylyltransferase and 2-aminoethylphosphonate (AEP) transaminase from Treponema denticola in complex with cytidine monophosphate-AEP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019700 | biological_process | organic phosphonate catabolic process |
| A | 0032923 | biological_process | organic phosphonate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019700 | biological_process | organic phosphonate catabolic process |
| B | 0032923 | biological_process | organic phosphonate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0019700 | biological_process | organic phosphonate catabolic process |
| C | 0032923 | biological_process | organic phosphonate biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0008483 | molecular_function | transaminase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0019700 | biological_process | organic phosphonate catabolic process |
| D | 0032923 | biological_process | organic phosphonate biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047304 | molecular_function | 2-aminoethylphosphonate-pyruvate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue PLP A 701 |
| Chain | Residue |
| A | SER313 |
| A | LYS441 |
| A | PO4704 |
| A | HOH883 |
| A | HOH988 |
| C | PHE489 |
| C | THR490 |
| A | GLY314 |
| A | THR315 |
| A | TYR340 |
| A | HIS388 |
| A | THR390 |
| A | ASP415 |
| A | VAL417 |
| A | SER418 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | ASP106 |
| A | GLU220 |
| A | ASP222 |
| A | MG703 |
| A | 0RC705 |
| A | HOH814 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 703 |
| Chain | Residue |
| A | ASP136 |
| A | GLU220 |
| A | ASP222 |
| A | MG702 |
| A | 0RC705 |
| A | HOH879 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 704 |
| Chain | Residue |
| A | TYR340 |
| A | TYR575 |
| A | PLP701 |
| A | HOH822 |
| A | HOH832 |
| A | HOH988 |
| A | HOH1006 |
| C | ARG276 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue 0RC A 705 |
| Chain | Residue |
| A | LEU8 |
| A | ALA9 |
| A | GLY10 |
| A | GLY11 |
| A | ARG15 |
| A | LYS25 |
| A | TYR80 |
| A | THR83 |
| A | GLY84 |
| A | SER85 |
| A | THR88 |
| A | GLU104 |
| A | SER105 |
| A | ASP106 |
| A | ASP136 |
| A | LYS153 |
| A | GLU196 |
| A | GLU220 |
| A | ASP222 |
| A | MG702 |
| A | MG703 |
| A | ACT715 |
| A | EDO717 |
| A | HOH814 |
| A | HOH828 |
| A | HOH879 |
| A | HOH1004 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 706 |
| Chain | Residue |
| A | PHE310 |
| A | GLY311 |
| A | TYR471 |
| A | GLN477 |
| A | THR487 |
| A | PHE489 |
| A | HOH848 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 707 |
| Chain | Residue |
| A | ARG276 |
| A | HOH824 |
| C | TYR575 |
| C | PRO576 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 708 |
| Chain | Residue |
| A | GLN285 |
| A | GLU306 |
| A | THR307 |
| A | EDO709 |
| A | HOH874 |
| A | HOH888 |
| A | HOH949 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 709 |
| Chain | Residue |
| A | CYS288 |
| A | THR307 |
| A | VAL308 |
| A | TYR478 |
| A | PHE481 |
| A | ALA482 |
| A | EDO708 |
| A | EDO710 |
| A | HOH888 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 710 |
| Chain | Residue |
| A | CYS288 |
| A | VAL308 |
| A | MET309 |
| A | GLN477 |
| A | PHE481 |
| A | THR487 |
| A | EDO709 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 711 |
| Chain | Residue |
| A | THR74 |
| A | HOH1113 |
| A | THR55 |
| A | ASN59 |
| A | ASP63 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 712 |
| Chain | Residue |
| A | ARG249 |
| A | THR261 |
| A | ASP262 |
| A | HOH846 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 713 |
| Chain | Residue |
| A | LEU293 |
| A | PHE294 |
| A | LEU296 |
| A | PRO424 |
| A | MET425 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 714 |
| Chain | Residue |
| A | TYR465 |
| A | MET467 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 715 |
| Chain | Residue |
| A | GLY13 |
| A | SER14 |
| A | ARG15 |
| A | 0RC705 |
| A | HOH1004 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 716 |
| Chain | Residue |
| A | VAL417 |
| A | TYR420 |
| A | SER437 |
| A | THR438 |
| A | LYS441 |
| A | ASN442 |
| A | ILE443 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 717 |
| Chain | Residue |
| A | ASP136 |
| A | GLU137 |
| A | VAL138 |
| A | LEU165 |
| A | GLU220 |
| A | 0RC705 |
| A | HOH807 |
| A | HOH844 |
| A | HOH879 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 718 |
| Chain | Residue |
| A | PRO553 |
| A | THR555 |
| A | PRO556 |
| A | TYR558 |
| A | HOH840 |
| A | HOH1039 |
| site_id | AE1 |
| Number of Residues | 16 |
| Details | binding site for residue PLP B 701 |
| Chain | Residue |
| B | SER313 |
| B | GLY314 |
| B | THR315 |
| B | TYR340 |
| B | HIS388 |
| B | THR390 |
| B | ASP415 |
| B | VAL417 |
| B | SER418 |
| B | LYS441 |
| B | PO4704 |
| B | HOH852 |
| B | HOH927 |
| B | HOH980 |
| D | PHE489 |
| D | THR490 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 702 |
| Chain | Residue |
| B | ASP106 |
| B | GLU220 |
| B | ASP222 |
| B | MG703 |
| B | 0RC705 |
| B | HOH819 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 703 |
| Chain | Residue |
| B | ASP136 |
| B | GLU220 |
| B | ASP222 |
| B | MG702 |
| B | 0RC705 |
| B | HOH823 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 704 |
| Chain | Residue |
| B | TYR340 |
| B | TYR575 |
| B | PLP701 |
| B | HOH860 |
| B | HOH899 |
| B | HOH980 |
| B | HOH1041 |
| D | ARG276 |
| D | THR490 |
| D | HOH974 |
| site_id | AE5 |
| Number of Residues | 27 |
| Details | binding site for residue 0RC B 705 |
| Chain | Residue |
| B | LEU8 |
| B | ALA9 |
| B | GLY10 |
| B | GLY11 |
| B | ARG15 |
| B | LYS25 |
| B | TYR80 |
| B | THR83 |
| B | GLY84 |
| B | SER85 |
| B | THR88 |
| B | GLU104 |
| B | SER105 |
| B | ASP106 |
| B | ASP136 |
| B | VAL138 |
| B | LYS153 |
| B | LEU165 |
| B | GLU196 |
| B | GLU220 |
| B | ASP222 |
| B | MG702 |
| B | MG703 |
| B | PO4708 |
| B | HOH819 |
| B | HOH823 |
| B | HOH1092 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 706 |
| Chain | Residue |
| B | ASP272 |
| B | ILE273 |
| B | VAL493 |
| B | GLN494 |
| D | PRO257 |
| D | ALA258 |
| D | THR260 |
| D | HOH1034 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 707 |
| Chain | Residue |
| B | CYS288 |
| B | VAL308 |
| B | MET309 |
| B | GLN477 |
| B | THR487 |
| B | HOH1021 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 B 708 |
| Chain | Residue |
| B | GLY13 |
| B | SER14 |
| B | ARG15 |
| B | 0RC705 |
| B | HOH896 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 709 |
| Chain | Residue |
| B | ASP289 |
| B | LYS292 |
| B | ASP303 |
| B | GLU306 |
| B | HOH979 |
| B | HOH1051 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 710 |
| Chain | Residue |
| B | ARG276 |
| B | HOH929 |
| B | HOH942 |
| B | HOH977 |
| B | HOH1078 |
| D | HIS564 |
| D | PRO576 |
| site_id | AF2 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 711 |
| Chain | Residue |
| B | PHE310 |
| B | GLY311 |
| B | TYR471 |
| B | GLN477 |
| B | THR487 |
| B | ARG488 |
| B | PHE489 |
| B | THR490 |
| B | PRO491 |
| B | HOH978 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 712 |
| Chain | Residue |
| B | PRO553 |
| B | THR555 |
| B | TYR558 |
| B | HOH801 |
| B | HOH812 |
| B | HOH835 |
| B | HOH1049 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 2201 |
| Chain | Residue |
| A | PRO576 |
| C | ARG276 |
| C | HOH2353 |
| C | HOH2542 |
| site_id | AF5 |
| Number of Residues | 14 |
| Details | binding site for residue PLP C 2202 |
| Chain | Residue |
| A | PHE489 |
| A | THR490 |
| C | SER313 |
| C | GLY314 |
| C | THR315 |
| C | TYR340 |
| C | HIS388 |
| C | THR390 |
| C | ASP415 |
| C | SER418 |
| C | PO42204 |
| C | HOH2378 |
| C | HOH2480 |
| C | HOH2488 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 2203 |
| Chain | Residue |
| C | ASP136 |
| C | GLU220 |
| C | ASP222 |
| C | 0RC2205 |
| C | MG2211 |
| C | HOH2345 |
| site_id | AF7 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 C 2204 |
| Chain | Residue |
| A | ARG276 |
| A | THR490 |
| C | TYR340 |
| C | TYR575 |
| C | PLP2202 |
| C | HOH2334 |
| C | HOH2399 |
| C | HOH2427 |
| C | HOH2480 |
| C | HOH2578 |
| site_id | AF8 |
| Number of Residues | 28 |
| Details | binding site for residue 0RC C 2205 |
| Chain | Residue |
| C | LEU8 |
| C | ALA9 |
| C | GLY10 |
| C | GLY11 |
| C | ARG15 |
| C | LYS25 |
| C | TYR80 |
| C | THR83 |
| C | GLY84 |
| C | SER85 |
| C | THR88 |
| C | GLU104 |
| C | SER105 |
| C | ASP106 |
| C | ASP136 |
| C | LYS153 |
| C | LEU165 |
| C | GLU196 |
| C | GLU220 |
| C | ASP222 |
| C | MG2203 |
| C | PO42207 |
| C | MG2211 |
| C | HOH2326 |
| C | HOH2345 |
| C | HOH2361 |
| C | HOH2432 |
| C | HOH2529 |
| site_id | AF9 |
| Number of Residues | 9 |
| Details | binding site for residue EDO C 2206 |
| Chain | Residue |
| A | ASN241 |
| A | HOH862 |
| C | ASP110 |
| C | TYR215 |
| C | PHE216 |
| C | VAL217 |
| C | ASN241 |
| C | HOH2341 |
| C | HOH2552 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 C 2207 |
| Chain | Residue |
| C | GLY13 |
| C | SER14 |
| C | ARG15 |
| C | 0RC2205 |
| C | HOH2432 |
| C | HOH2527 |
| site_id | AG2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO C 2208 |
| Chain | Residue |
| C | TYR305 |
| C | LYS406 |
| C | LEU427 |
| C | GLY431 |
| C | ILE432 |
| C | ASP433 |
| C | ASN455 |
| C | HOH2501 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 2209 |
| Chain | Residue |
| C | SER360 |
| C | SER361 |
| C | HOH2315 |
| C | HOH2448 |
| D | LYS463 |
| D | TYR465 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 2210 |
| Chain | Residue |
| C | LYS346 |
| C | ASP349 |
| C | ILE350 |
| C | HOH2303 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 2211 |
| Chain | Residue |
| C | ASP106 |
| C | GLU220 |
| C | ASP222 |
| C | MG2203 |
| C | 0RC2205 |
| C | HOH2326 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 2212 |
| Chain | Residue |
| C | PHE310 |
| C | GLY311 |
| C | TYR471 |
| C | GLN477 |
| C | THR487 |
| C | PHE489 |
| C | HOH2374 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 2213 |
| Chain | Residue |
| C | GLN285 |
| C | GLU306 |
| C | THR307 |
| C | HOH2376 |
| C | HOH2545 |
| C | HOH2629 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 2214 |
| Chain | Residue |
| C | CYS288 |
| C | VAL308 |
| C | MET309 |
| C | GLN477 |
| C | PHE481 |
| C | THR487 |
| C | HOH2350 |
| site_id | AG9 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 C 2215 |
| Chain | Residue |
| C | PRO553 |
| C | GLU554 |
| C | THR555 |
| C | PRO556 |
| C | TYR558 |
| C | HOH2313 |
| C | HOH2331 |
| C | HOH2335 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 701 |
| Chain | Residue |
| D | ASP136 |
| D | GLU220 |
| D | ASP222 |
| D | MG703 |
| D | 0RC705 |
| D | HOH841 |
| site_id | AH2 |
| Number of Residues | 16 |
| Details | binding site for residue PLP D 702 |
| Chain | Residue |
| B | PHE489 |
| B | THR490 |
| D | SER313 |
| D | GLY314 |
| D | THR315 |
| D | TYR340 |
| D | HIS388 |
| D | THR390 |
| D | ASP415 |
| D | SER418 |
| D | LYS441 |
| D | PO4709 |
| D | HOH801 |
| D | HOH836 |
| D | HOH915 |
| D | HOH961 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 703 |
| Chain | Residue |
| D | ASP106 |
| D | GLU220 |
| D | ASP222 |
| D | MG701 |
| D | 0RC705 |
| D | HOH803 |
| site_id | AH4 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 D 704 |
| Chain | Residue |
| D | LEU12 |
| D | 0RC705 |
| site_id | AH5 |
| Number of Residues | 26 |
| Details | binding site for residue 0RC D 705 |
| Chain | Residue |
| D | LEU8 |
| D | ALA9 |
| D | GLY10 |
| D | GLY11 |
| D | LYS25 |
| D | TYR80 |
| D | THR83 |
| D | GLY84 |
| D | SER85 |
| D | THR88 |
| D | GLU104 |
| D | SER105 |
| D | ASP106 |
| D | ASP136 |
| D | VAL138 |
| D | LYS153 |
| D | LEU165 |
| D | GLU196 |
| D | GLU220 |
| D | ASP222 |
| D | MG701 |
| D | MG703 |
| D | PO4704 |
| D | HOH803 |
| D | HOH978 |
| D | HOH1016 |
| site_id | AH6 |
| Number of Residues | 9 |
| Details | binding site for residue EDO D 706 |
| Chain | Residue |
| D | SER323 |
| D | VAL326 |
| D | PRO327 |
| D | TYR465 |
| D | PRO466 |
| D | ARG468 |
| D | HOH857 |
| D | HOH917 |
| D | HOH981 |
| site_id | AH7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 707 |
| Chain | Residue |
| B | TYR266 |
| D | HIS46 |
| D | PHE115 |
| D | ARG245 |
| site_id | AH8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 708 |
| Chain | Residue |
| D | ARG245 |
| D | ASP262 |
| D | TYR266 |
| site_id | AH9 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 D 709 |
| Chain | Residue |
| B | ARG276 |
| D | TYR340 |
| D | TYR575 |
| D | PLP702 |
| D | HOH801 |
| D | HOH862 |
| D | HOH904 |
| D | HOH927 |
| D | HOH933 |
| D | HOH961 |
| site_id | AI1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 710 |
| Chain | Residue |
| D | GLN285 |
| D | GLU306 |
| D | THR307 |
| D | HOH845 |
| D | HOH954 |
| D | HOH1027 |
| site_id | AI2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 711 |
| Chain | Residue |
| D | VAL308 |
| D | MET309 |
| D | GLN477 |
| D | THR487 |
| D | HOH950 |
| site_id | AI3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 712 |
| Chain | Residue |
| D | PHE310 |
| D | GLY311 |
| D | TYR471 |
| D | GLN477 |
| D | THR487 |
| D | PHE489 |
| D | HOH835 |
| site_id | AI4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 713 |
| Chain | Residue |
| B | PRO576 |
| B | HOH843 |
| D | ARG276 |
| site_id | AI5 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 D 714 |
| Chain | Residue |
| D | GLU554 |
| D | THR555 |
| D | TYR558 |
| D | HOH802 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 717 |
| Details | Region: {"description":"2-aminoethylphosphonate cytidylyltransferase","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31420548","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PD2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 366 |
| Details | Region: {"description":"2-aminoethylphosphonate aminotransferase","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
