6PCC
Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex hexanoyl coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0010124 | biological_process | phenylacetate catabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| A | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| B | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0010124 | biological_process | phenylacetate catabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| B | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| C | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| C | 0006635 | biological_process | fatty acid beta-oxidation |
| C | 0010124 | biological_process | phenylacetate catabolic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| C | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
| D | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| D | 0006635 | biological_process | fatty acid beta-oxidation |
| D | 0010124 | biological_process | phenylacetate catabolic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
| D | 0033812 | molecular_function | 3-oxoadipyl-CoA thiolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue COA A 1001 |
| Chain | Residue |
| A | CYS90 |
| A | ASN322 |
| A | PHE325 |
| A | LEU358 |
| A | HOH1103 |
| A | HOH1206 |
| A | HOH1252 |
| A | HOH1256 |
| A | HOH1309 |
| A | HOH1319 |
| B | HOH790 |
| A | ILE145 |
| A | MET163 |
| A | ARG226 |
| A | THR229 |
| A | ALA249 |
| A | GLY250 |
| A | SER253 |
| A | GLY254 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue O8Y A 1002 |
| Chain | Residue |
| A | ASN58 |
| A | THR143 |
| A | THR144 |
| A | ILE145 |
| A | GLY146 |
| A | ARG148 |
| A | MET163 |
| A | LEU358 |
| A | HOH1114 |
| A | HOH1147 |
| A | HOH1169 |
| D | ARG65 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1003 |
| Chain | Residue |
| A | ARG187 |
| A | SER188 |
| A | LYS191 |
| A | GLU323 |
| A | VAL345 |
| A | ASN346 |
| A | GLY349 |
| A | HOH1102 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue O8Y B 502 |
| Chain | Residue |
| B | ASN58 |
| B | LEU89 |
| B | THR143 |
| B | ILE145 |
| B | GLY146 |
| B | ARG148 |
| B | MET163 |
| B | LEU358 |
| B | HOH694 |
| B | HOH780 |
| C | ARG65 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | ARG187 |
| B | SER188 |
| B | LYS191 |
| B | GLU323 |
| B | ASP340 |
| B | VAL345 |
| B | ASN346 |
| B | GLY349 |
| B | HOH624 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue O8Y C 502 |
| Chain | Residue |
| B | ARG65 |
| C | ALA57 |
| C | ASN58 |
| C | LEU89 |
| C | THR143 |
| C | THR144 |
| C | ILE145 |
| C | GLY146 |
| C | ARG148 |
| C | LEU358 |
| C | HOH682 |
| C | HOH806 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | PHE184 |
| C | ARG187 |
| C | SER188 |
| C | LYS191 |
| C | GLU323 |
| C | ASP340 |
| C | ASP341 |
| C | VAL345 |
| C | ASN346 |
| C | GLY349 |
| C | HOH644 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue O8Y D 502 |
| Chain | Residue |
| A | ARG65 |
| D | ASN58 |
| D | LEU89 |
| D | THR143 |
| D | ILE145 |
| D | GLY146 |
| D | ARG148 |
| D | LEU358 |
| D | HOH825 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| D | HOH641 |
| D | PHE184 |
| D | ARG187 |
| D | SER188 |
| D | LYS191 |
| D | GLU323 |
| D | VAL345 |
| D | ASN346 |
| D | GLY349 |
Functional Information from PROSITE/UniProt
