6P86
E.coli LpxD in complex with compound 4.1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016410 | molecular_function | N-acyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016410 | molecular_function | N-acyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016410 | molecular_function | N-acyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | HOH598 |
| A | HOH715 |
| B | HOH680 |
| B | HOH845 |
| C | HOH659 |
| C | HOH844 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| B | HOH678 |
| C | ASN121 |
| C | HOH628 |
| A | ASN121 |
| A | HOH541 |
| B | ASN121 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue O4S A 403 |
| Chain | Residue |
| A | ALA248 |
| A | ALA250 |
| A | GLY268 |
| A | GLY269 |
| A | THR286 |
| A | GLY287 |
| C | VAL272 |
| C | ASN274 |
| C | MET290 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue O3V B 501 |
| Chain | Residue |
| A | PHE183 |
| A | ILE254 |
| A | ALA256 |
| B | ALA250 |
| B | GLY268 |
| B | GLY269 |
| B | VAL285 |
| B | HOH610 |
| B | HOH643 |
| B | HOH669 |
| B | HOH714 |
| C | GLU49 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue O3V C 501 |
| Chain | Residue |
| B | GLU49 |
| B | PHE183 |
| B | TYR185 |
| B | ILE254 |
| B | ASN274 |
| B | HOH683 |
| C | ALA250 |
| C | GLY268 |
| C | GLY269 |
| C | HOH612 |
| C | HOH633 |
| C | HOH718 |
Functional Information from PROSITE/UniProt
| site_id | PS00101 |
| Number of Residues | 29 |
| Details | HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV |
| Chain | Residue | Details |
| A | ILE100-VAL128 | |
| A | ILE106-VAL134 | |
| A | LEU130-VAL158 | |
| A | ILE225-VAL253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Involved in determining the hydroxyacyl-ACP selectivity"} |
| Chain | Residue | Details |
