6P6V

HCV NS3/4A protease domain of genotype 5a in complex with glecaprevir

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	symbiont-mediated transformation of host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 1202

Chain	Residue
A	ARG1155
A	ASN1174
A	HOH1493

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 1203

Chain	Residue
A	VAL1078
A	HOH1338

---

site_id	AC4
Number of Residues	26
Details	binding site for residue O31 A 1204

Chain	Residue
A	THR1004
A	ALA1005
A	TYR1006
A	GLN1041
A	THR1042
A	PHE1056
A	HIS1057
A	ASP1081
A	ARG1123
A	ILE1132
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	ASP1168
A	HOH1326
A	HOH1364
A	HOH1368
A	HOH1384
A	HOH1386
A	HOH1420

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	181
Details	Domain: {"description":"Peptidase S29","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage; by protease NS2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01030","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---