6P4X

Crystal Structure of the S. cerevisiae glucokinase, Glk1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001678	biological_process	intracellular glucose homeostasis
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	D-glucose binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006096	biological_process	glycolytic process
A	0008865	molecular_function	fructokinase activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019318	biological_process	hexose metabolic process
A	0046323	biological_process	D-glucose import
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process
B	0000166	molecular_function	nucleotide binding
B	0001678	biological_process	intracellular glucose homeostasis
B	0004340	molecular_function	glucokinase activity
B	0004396	molecular_function	hexokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005536	molecular_function	D-glucose binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006013	biological_process	mannose metabolic process
B	0006096	biological_process	glycolytic process
B	0008865	molecular_function	fructokinase activity
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019318	biological_process	hexose metabolic process
B	0046323	biological_process	D-glucose import
B	0046835	biological_process	carbohydrate phosphorylation
B	0051156	biological_process	glucose 6-phosphate metabolic process
C	0000166	molecular_function	nucleotide binding
C	0001678	biological_process	intracellular glucose homeostasis
C	0004340	molecular_function	glucokinase activity
C	0004396	molecular_function	hexokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005536	molecular_function	D-glucose binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005975	biological_process	carbohydrate metabolic process
C	0006006	biological_process	glucose metabolic process
C	0006013	biological_process	mannose metabolic process
C	0006096	biological_process	glycolytic process
C	0008865	molecular_function	fructokinase activity
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019318	biological_process	hexose metabolic process
C	0046323	biological_process	D-glucose import
C	0046835	biological_process	carbohydrate phosphorylation
C	0051156	biological_process	glucose 6-phosphate metabolic process
D	0000166	molecular_function	nucleotide binding
D	0001678	biological_process	intracellular glucose homeostasis
D	0004340	molecular_function	glucokinase activity
D	0004396	molecular_function	hexokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005536	molecular_function	D-glucose binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005975	biological_process	carbohydrate metabolic process
D	0006006	biological_process	glucose metabolic process
D	0006013	biological_process	mannose metabolic process
D	0006096	biological_process	glycolytic process
D	0008865	molecular_function	fructokinase activity
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019318	biological_process	hexose metabolic process
D	0046323	biological_process	D-glucose import
D	0046835	biological_process	carbohydrate phosphorylation
D	0051156	biological_process	glucose 6-phosphate metabolic process
E	0000166	molecular_function	nucleotide binding
E	0001678	biological_process	intracellular glucose homeostasis
E	0004340	molecular_function	glucokinase activity
E	0004396	molecular_function	hexokinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005536	molecular_function	D-glucose binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005975	biological_process	carbohydrate metabolic process
E	0006006	biological_process	glucose metabolic process
E	0006013	biological_process	mannose metabolic process
E	0006096	biological_process	glycolytic process
E	0008865	molecular_function	fructokinase activity
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
E	0019318	biological_process	hexose metabolic process
E	0046323	biological_process	D-glucose import
E	0046835	biological_process	carbohydrate phosphorylation
E	0051156	biological_process	glucose 6-phosphate metabolic process
F	0000166	molecular_function	nucleotide binding
F	0001678	biological_process	intracellular glucose homeostasis
F	0004340	molecular_function	glucokinase activity
F	0004396	molecular_function	hexokinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005536	molecular_function	D-glucose binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005975	biological_process	carbohydrate metabolic process
F	0006006	biological_process	glucose metabolic process
F	0006013	biological_process	mannose metabolic process
F	0006096	biological_process	glycolytic process
F	0008865	molecular_function	fructokinase activity
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
F	0019318	biological_process	hexose metabolic process
F	0046323	biological_process	D-glucose import
F	0046835	biological_process	carbohydrate phosphorylation
F	0051156	biological_process	glucose 6-phosphate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 601

Chain	Residue
A	ARG416
A	SER461
A	MET462
A	HIS465
C	HIS441
C	LYS479

---

site_id	AC2
Number of Residues	2
Details	binding site for residue PO4 A 602

Chain	Residue
A	ARG360
A	ARG396

---

site_id	AC3
Number of Residues	2
Details	binding site for residue PO4 A 603

Chain	Residue
A	SER451
A	THR252

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 B 601

Chain	Residue
B	ARG416
B	SER461
B	MET462
B	HIS465
E	HIS441

---

site_id	AC5
Number of Residues	3
Details	binding site for residue PO4 B 602

Chain	Residue
B	GLY251
B	THR252
B	SER451

---

site_id	AC6
Number of Residues	5
Details	binding site for residue PO4 C 601

Chain	Residue
A	HIS441
C	ARG416
C	SER461
C	MET462
C	HIS465

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PO4 C 602

Chain	Residue
C	GLY251
C	THR252
C	GLY450
C	SER451

---

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 D 601

Chain	Residue
D	ARG416
D	SER461
D	MET462
D	HIS465
F	TYR440
F	HIS441
F	ARG478

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 D 602

Chain	Residue
D	GLY251
D	THR252
D	GLY450
D	SER451

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 E 601

Chain	Residue
B	HIS441
B	LYS479
E	ARG416
E	SER461
E	MET462
E	HIS465

---

site_id	AD2
Number of Residues	3
Details	binding site for residue PO4 E 602

Chain	Residue
E	THR252
E	GLY450
E	SER451

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 F 601

Chain	Residue
D	TYR440
D	HIS441
F	ARG416
F	SER461
F	HIS465

---

site_id	AD4
Number of Residues	4
Details	binding site for residue PO4 F 602

Chain	Residue
F	GLY251
F	THR252
F	GLY450
F	SER451

---

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPvdqtsLNsgtLirWTKgF

Chain	Residue	Details
A	LEU159-PHE184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	852
Details	Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	156
Details	Region: {"description":"Glucose-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1620
Details	Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---