6P4W
XPB helicase in a complex with truncated Bax1 from Sulfurisphaera tokodaii at 2.96 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| A | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| A | 0140097 | molecular_function | catalytic activity, acting on DNA |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006281 | biological_process | DNA repair |
| C | 0006974 | biological_process | DNA damage response |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| C | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| C | 0140097 | molecular_function | catalytic activity, acting on DNA |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 501 |
| Chain | Residue |
| A | GLY93 |
| A | GLY95 |
| A | LYS96 |
| A | ARG127 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | LYS96 |
| A | ASP174 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | LYS426 |
| A | HOH613 |
| A | HOH626 |
| A | HIS178 |
| A | SER181 |
| A | ARG205 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | LYS251 |
| A | ASP255 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | GLU357 |
| A | GLU360 |
| A | ILE361 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | ASP155 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 507 |
| Chain | Residue |
| A | TYR3 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 508 |
| Chain | Residue |
| A | VAL348 |
| A | THR353 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 509 |
| Chain | Residue |
| A | ALA235 |
| A | ARG412 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 510 |
| Chain | Residue |
| A | LYS66 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 511 |
| Chain | Residue |
| A | ARG37 |
| A | ARG40 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 401 |
| Chain | Residue |
| B | TYR182 |
| B | ILE295 |
| B | GLU310 |
| B | LYS323 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 C 501 |
| Chain | Residue |
| C | GLY93 |
| C | GLY95 |
| C | LYS96 |
| C | THR97 |
| C | ARG127 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue MG C 502 |
| Chain | Residue |
| C | ASP174 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | SER245 |
| C | LYS426 |
| C | HOH610 |
| C | HOH614 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 504 |
| Chain | Residue |
| C | LYS251 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 505 |
| Chain | Residue |
| C | TYR3 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 507 |
| Chain | Residue |
| C | ASP155 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 508 |
| Chain | Residue |
| C | GLU357 |
| C | TYR370 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 509 |
| Chain | Residue |
| C | HIS178 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 510 |
| Chain | Residue |
| C | ASP155 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 401 |
| Chain | Residue |
| C | HIS299 |
| D | GLU47 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 288 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"Flexible hinge region","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 118 |
| Details | Region: {"description":"ThM region","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Motif: {"description":"RED motif","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Wedge residue","evidences":[{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 184 |
| Details | Region: {"description":"Central domain (CRD)","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 208 |
| Details | Region: {"description":"Nuclease domain (NUS)","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O29890","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
