6P4C

HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CL L 301

Chain	Residue
L	VAL13
L	THR14
L	ASN17

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL L 302

Chain	Residue
L	LEU181
L	THR182
L	GLU185

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site_id	AC3
Number of Residues	5
Details	binding site for residue CL L 303

Chain	Residue
L	SER191
L	THR193
L	LYS149
L	ASP151
L	GLY152

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site_id	AC4
Number of Residues	3
Details	binding site for residue CL H 301

Chain	Residue
H	ASP27
H	THR86
H	THR87

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site_id	AC5
Number of Residues	4
Details	binding site for residue CL H 302

Chain	Residue
H	TYR145
H	GLU148
H	PRO149
H	VAL150

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site_id	AC6
Number of Residues	3
Details	binding site for residue CL H 303

Chain	Residue
H	ASN155
H	SER156
H	ASN196

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site_id	AC7
Number of Residues	1
Details	binding site for residue CL H 304

Chain	Residue
H	GLY26

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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