6P2P

Tetrameric structure of ACAT1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
A	0004772	molecular_function	sterol O-acyltransferase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008374	molecular_function	O-acyltransferase activity
A	0010742	biological_process	macrophage derived foam cell differentiation
A	0010878	biological_process	cholesterol storage
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0033344	biological_process	cholesterol efflux
A	0034379	biological_process	very-low-density lipoprotein particle assembly
A	0034383	biological_process	low-density lipoprotein particle clearance
A	0034736	molecular_function	cholesterol O-acyltransferase activity
A	0042632	biological_process	cholesterol homeostasis
A	0042986	biological_process	positive regulation of amyloid precursor protein biosynthetic process
B	0000062	molecular_function	fatty-acyl-CoA binding
B	0004772	molecular_function	sterol O-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008374	molecular_function	O-acyltransferase activity
B	0010742	biological_process	macrophage derived foam cell differentiation
B	0010878	biological_process	cholesterol storage
B	0015485	molecular_function	cholesterol binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0033344	biological_process	cholesterol efflux
B	0034379	biological_process	very-low-density lipoprotein particle assembly
B	0034383	biological_process	low-density lipoprotein particle clearance
B	0034736	molecular_function	cholesterol O-acyltransferase activity
B	0042632	biological_process	cholesterol homeostasis
B	0042986	biological_process	positive regulation of amyloid precursor protein biosynthetic process
C	0000062	molecular_function	fatty-acyl-CoA binding
C	0004772	molecular_function	sterol O-acyltransferase activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008374	molecular_function	O-acyltransferase activity
C	0010742	biological_process	macrophage derived foam cell differentiation
C	0010878	biological_process	cholesterol storage
C	0015485	molecular_function	cholesterol binding
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0033344	biological_process	cholesterol efflux
C	0034379	biological_process	very-low-density lipoprotein particle assembly
C	0034383	biological_process	low-density lipoprotein particle clearance
C	0034736	molecular_function	cholesterol O-acyltransferase activity
C	0042632	biological_process	cholesterol homeostasis
C	0042986	biological_process	positive regulation of amyloid precursor protein biosynthetic process
D	0000062	molecular_function	fatty-acyl-CoA binding
D	0004772	molecular_function	sterol O-acyltransferase activity
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008374	molecular_function	O-acyltransferase activity
D	0010742	biological_process	macrophage derived foam cell differentiation
D	0010878	biological_process	cholesterol storage
D	0015485	molecular_function	cholesterol binding
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0033344	biological_process	cholesterol efflux
D	0034379	biological_process	very-low-density lipoprotein particle assembly
D	0034383	biological_process	low-density lipoprotein particle clearance
D	0034736	molecular_function	cholesterol O-acyltransferase activity
D	0042632	biological_process	cholesterol homeostasis
D	0042986	biological_process	positive regulation of amyloid precursor protein biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 3VV A 700

Chain	Residue
A	SER414
A	PHE453
A	SER456
A	HIS460
A	ASN415
A	TRP420
A	HIS425
A	LEU428
A	TYR429
A	TYR433
A	LYS445
A	VAL452

---

site_id	AC2
Number of Residues	13
Details	binding site for residue 3VV B 700

Chain	Residue
B	TRP407
B	SER414
B	ASN415
B	TRP420
B	ASN421
B	HIS425
B	TYR433
B	LYS445
B	PHE453
B	SER456
B	HIS460
B	PHE476
B	MET480

---

site_id	AC3
Number of Residues	12
Details	binding site for residue 3VV C 700

Chain	Residue
C	SER414
C	ASN415
C	TRP420
C	HIS425
C	LEU428
C	TYR429
C	TYR433
C	LYS445
C	VAL452
C	PHE453
C	SER456
C	HIS460

---

site_id	AC4
Number of Residues	13
Details	binding site for residue 3VV D 700

Chain	Residue
D	TRP407
D	SER414
D	ASN415
D	TRP420
D	ASN421
D	HIS425
D	TYR433
D	LYS445
D	PHE453
D	SER456
D	HIS460
D	PHE476
D	MET480

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	968
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-ILE138
B	ASN491-LYS496
C	MET1-ILE138
C	ALA207-ILE218
C	ARG277-ARG319
C	LEU396-ARG443
C	ASN491-LYS496
D	MET1-ILE138
D	ALA207-ILE218
D	ARG277-ARG319
D	LEU396-ARG443
A	ALA207-ILE218
D	ASN491-LYS496
A	ARG277-ARG319
A	LEU396-ARG443
A	ASN491-LYS496
B	MET1-ILE138
B	ALA207-ILE218
B	ARG277-ARG319
B	LEU396-ARG443

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	ARG139-ASP160
B	ARG139-ASP160
C	ARG139-ASP160
D	ARG139-ASP160

---

site_id	SWS_FT_FI3
Number of Residues	272
Details	TOPO_DOM: Lumenal => ECO:0000305

Chain	Residue	Details
A	TYR161-LYS180
B	PRO529-PHE550
C	TYR161-LYS180
C	ALA245-SER252
C	LYS353-SER369
C	SER469-VAL474
C	PRO529-PHE550
D	TYR161-LYS180
D	ALA245-SER252
D	LYS353-SER369
D	SER469-VAL474
A	ALA245-SER252
D	PRO529-PHE550
A	LYS353-SER369
A	SER469-VAL474
A	PRO529-PHE550
B	TYR161-LYS180
B	ALA245-SER252
B	LYS353-SER369
B	SER469-VAL474

---

site_id	SWS_FT_FI4
Number of Residues	100
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	PHE181-TRP206
B	PHE181-TRP206
C	PHE181-TRP206
D	PHE181-TRP206

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	ARG219-LEU244
B	ARG219-LEU244
C	ARG219-LEU244
D	ARG219-LEU244

---

site_id	SWS_FT_FI6
Number of Residues	92
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	ARG253-PRO276
B	ARG253-PRO276
C	ARG253-PRO276
D	ARG253-PRO276

---

site_id	SWS_FT_FI7
Number of Residues	128
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	TRP320-ILE352
B	TRP320-ILE352
C	TRP320-ILE352
D	TRP320-ILE352

---

site_id	SWS_FT_FI8
Number of Residues	100
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	ILE370-MET395
B	ILE370-MET395
C	ILE370-MET395
D	ILE370-MET395

---

site_id	SWS_FT_FI9
Number of Residues	96
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	PHE444-LEU468
B	PHE444-LEU468
C	PHE444-LEU468
D	PHE444-LEU468

---

site_id	SWS_FT_FI10
Number of Residues	60
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	LEU475-VAL490
B	LEU475-VAL490
C	LEU475-VAL490
D	LEU475-VAL490

---

site_id	SWS_FT_FI11
Number of Residues	124
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	PRO497-CYS528
B	PRO497-CYS528
C	PRO497-CYS528
D	PRO497-CYS528

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	HIS460
B	HIS460
C	HIS460
D	HIS460

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:32433613, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	HIS137
C	ARG418
C	TYR433
C	SER456
D	HIS137
D	ARG418
D	TYR433
D	SER456
A	ARG418
A	TYR433
A	SER456
B	HIS137
B	ARG418
B	TYR433
B	SER456
C	HIS137

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2P

Chain	Residue	Details
A	ASN415
B	ASN415
C	ASN415
D	ASN415

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J

Chain	Residue	Details
A	ASN421
B	ASN421
C	ASN421
D	ASN421

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM

Chain	Residue	Details
A	HIS425
A	LYS445
B	HIS425
B	LYS445
C	HIS425
C	LYS445
D	HIS425
D	LYS445

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER8
B	SER8
C	SER8
D	SER8

---