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6OWO

CRYO-EM STRUCTURE OF PHOSPHORYLATED AP-2 CORE BOUND TO NECAP

Functional Information from GO Data
ChainGOidnamespacecontents
A0005794cellular_componentGolgi apparatus
A0006886biological_processintracellular protein transport
A0016192biological_processvesicle-mediated transport
A0030117cellular_componentmembrane coat
A0030121cellular_componentAP-1 adaptor complex
B0006886biological_processintracellular protein transport
B0015031biological_processprotein transport
B0016192biological_processvesicle-mediated transport
B0030117cellular_componentmembrane coat
B0030276molecular_functionclathrin binding
M0002092biological_processpositive regulation of receptor internalization
M0005048molecular_functionsignal sequence binding
M0005515molecular_functionprotein binding
M0005739cellular_componentmitochondrion
M0005886cellular_componentplasma membrane
M0005905cellular_componentclathrin-coated pit
M0006886biological_processintracellular protein transport
M0006897biological_processendocytosis
M0006900biological_processvesicle budding from membrane
M0008289molecular_functionlipid binding
M0009898cellular_componentcytoplasmic side of plasma membrane
M0015031biological_processprotein transport
M0016020cellular_componentmembrane
M0016192biological_processvesicle-mediated transport
M0030122cellular_componentAP-2 adaptor complex
M0030131cellular_componentclathrin adaptor complex
M0030141cellular_componentsecretory granule
M0031410cellular_componentcytoplasmic vesicle
M0031623biological_processreceptor internalization
M0035615molecular_functionclathrin adaptor activity
M0044325molecular_functiontransmembrane transporter binding
M0045202cellular_componentsynapse
M0048488biological_processsynaptic vesicle endocytosis
M0050750molecular_functionlow-density lipoprotein particle receptor binding
M0051649biological_processestablishment of localization in cell
M0065003biological_processprotein-containing complex assembly
M0072583biological_processclathrin-dependent endocytosis
M0097494biological_processregulation of vesicle size
M0097718molecular_functiondisordered domain specific binding
M0098794cellular_componentpostsynapse
M0098884biological_processpostsynaptic neurotransmitter receptor internalization
M0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
M0098978cellular_componentglutamatergic synapse
M1900244biological_processpositive regulation of synaptic vesicle endocytosis
M1903077biological_processnegative regulation of protein localization to plasma membrane
N0003674molecular_functionmolecular_function
N0005886cellular_componentplasma membrane
N0006897biological_processendocytosis
N0015031biological_processprotein transport
N0016020cellular_componentmembrane
N0016192biological_processvesicle-mediated transport
N0030125cellular_componentclathrin vesicle coat
N0030665cellular_componentclathrin-coated vesicle membrane
N0031410cellular_componentcytoplasmic vesicle
S0005886cellular_componentplasma membrane
S0005905cellular_componentclathrin-coated pit
S0006886biological_processintracellular protein transport
S0006897biological_processendocytosis
S0008150biological_processbiological_process
S0015031biological_processprotein transport
S0016020cellular_componentmembrane
S0016192biological_processvesicle-mediated transport
S0030117cellular_componentmembrane coat
S0030122cellular_componentAP-2 adaptor complex
S0035615molecular_functionclathrin adaptor activity
S0043231cellular_componentintracellular membrane-bounded organelle
S0045202cellular_componentsynapse
S0048488biological_processsynaptic vesicle endocytosis
S0071944cellular_componentcell periphery
S0072583biological_processclathrin-dependent endocytosis
S0098794cellular_componentpostsynapse
S0098884biological_processpostsynaptic neurotransmitter receptor internalization
S0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
S0098978cellular_componentglutamatergic synapse
Functional Information from PROSITE/UniProt
site_idPS00990
Number of Residues21
DetailsCLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE
ChainResidueDetails
MILE159-GLU179

site_idPS00991
Number of Residues15
DetailsCLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY
ChainResidueDetails
MILE263-TYR277

site_idPS00989
Number of Residues11
DetailsCLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF
ChainResidueDetails
SILE57-PHE67

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P18484
ChainResidueDetails
AARG11
ALYS43
ATYR53
ALYS57

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96CW1
ChainResidueDetails
MSER45

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079
ChainResidueDetails
MTPO156

218853

PDB entries from 2024-04-24

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