Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6OT5

Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue FZ4 A 1001

Chain	Residue
A	HIS417
A	LEU420
A	THR421
A	LEU422
A	HIS426
A	LEU429
A	ARG693

site_id	AC2
Number of Residues	7
Details	binding site for residue FZ4 B 1001

Chain	Residue
B	THR421
B	LEU422
B	HIS426
B	LEU429
B	ARG693
B	HIS417
B	LEU420

site_id	AC3
Number of Residues	7
Details	binding site for residue FZ4 C 1001

Chain	Residue
C	HIS417
C	LEU420
C	THR421
C	LEU422
C	HIS426
C	LEU429
C	ARG693

site_id	AC4
Number of Residues	7
Details	binding site for residue FZ4 D 1001

Chain	Residue
D	HIS417
D	LEU420
D	THR421
D	LEU422
D	HIS426
D	LEU429
D	ARG693

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	68
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	100
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	124
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	116
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	120
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	128
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	88
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)