6OOV
Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0006974 | biological_process | DNA damage response |
| A | 0106300 | biological_process | protein-DNA covalent cross-linking repair |
| B | 0003697 | molecular_function | single-stranded DNA binding |
| B | 0006974 | biological_process | DNA damage response |
| B | 0106300 | biological_process | protein-DNA covalent cross-linking repair |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:31235913, ECO:0000305|PubMed:30554877 |
| Chain | Residue | Details |
| A | CYS2 | |
| B | CYS2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866 |
| Chain | Residue | Details |
| A | GLU127 | |
| B | GLU127 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Required for sensing abasic sites => ECO:0000250|UniProtKB:P76318 |
| Chain | Residue | Details |
| A | GLU127 | |
| B | GLU127 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Required to stabilize abasic sites => ECO:0000250|UniProtKB:P76318 |
| Chain | Residue | Details |
| A | HIS210 | |
| B | HIS210 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Thiazolidine linkage to a ring-opened DNA abasic site => ECO:0000269|PubMed:31235913 |
| Chain | Residue | Details |
| A | CYS2 | |
| B | CYS2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER160 | |
| B | SER160 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS148 | |
| A | LYS151 | |
| B | LYS148 | |
| B | LYS151 |
