6OM8

Caenorhabditis Elegans UDP-Glucose Dehydrogenase in complex with UDP-Xylose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002009	biological_process	morphogenesis of an epithelium
A	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006024	biological_process	glycosaminoglycan biosynthetic process
A	0006065	biological_process	UDP-glucuronate biosynthetic process
A	0009792	biological_process	embryo development ending in birth or egg hatching
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0018991	biological_process	egg-laying behavior
A	0040025	biological_process	vulval development
A	0042802	molecular_function	identical protein binding
A	0051287	molecular_function	NAD binding
B	0002009	biological_process	morphogenesis of an epithelium
B	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006024	biological_process	glycosaminoglycan biosynthetic process
B	0006065	biological_process	UDP-glucuronate biosynthetic process
B	0009792	biological_process	embryo development ending in birth or egg hatching
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0018991	biological_process	egg-laying behavior
B	0040025	biological_process	vulval development
B	0042802	molecular_function	identical protein binding
B	0051287	molecular_function	NAD binding
C	0002009	biological_process	morphogenesis of an epithelium
C	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006024	biological_process	glycosaminoglycan biosynthetic process
C	0006065	biological_process	UDP-glucuronate biosynthetic process
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0018991	biological_process	egg-laying behavior
C	0040025	biological_process	vulval development
C	0042802	molecular_function	identical protein binding
C	0051287	molecular_function	NAD binding
D	0002009	biological_process	morphogenesis of an epithelium
D	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006024	biological_process	glycosaminoglycan biosynthetic process
D	0006065	biological_process	UDP-glucuronate biosynthetic process
D	0009792	biological_process	embryo development ending in birth or egg hatching
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0018991	biological_process	egg-laying behavior
D	0040025	biological_process	vulval development
D	0042802	molecular_function	identical protein binding
D	0051287	molecular_function	NAD binding
E	0002009	biological_process	morphogenesis of an epithelium
E	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006024	biological_process	glycosaminoglycan biosynthetic process
E	0006065	biological_process	UDP-glucuronate biosynthetic process
E	0009792	biological_process	embryo development ending in birth or egg hatching
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0018991	biological_process	egg-laying behavior
E	0040025	biological_process	vulval development
E	0042802	molecular_function	identical protein binding
E	0051287	molecular_function	NAD binding
F	0002009	biological_process	morphogenesis of an epithelium
F	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006024	biological_process	glycosaminoglycan biosynthetic process
F	0006065	biological_process	UDP-glucuronate biosynthetic process
F	0009792	biological_process	embryo development ending in birth or egg hatching
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0018991	biological_process	egg-laying behavior
F	0040025	biological_process	vulval development
F	0042802	molecular_function	identical protein binding
F	0051287	molecular_function	NAD binding
G	0002009	biological_process	morphogenesis of an epithelium
G	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006024	biological_process	glycosaminoglycan biosynthetic process
G	0006065	biological_process	UDP-glucuronate biosynthetic process
G	0009792	biological_process	embryo development ending in birth or egg hatching
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0018991	biological_process	egg-laying behavior
G	0040025	biological_process	vulval development
G	0042802	molecular_function	identical protein binding
G	0051287	molecular_function	NAD binding
H	0002009	biological_process	morphogenesis of an epithelium
H	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006024	biological_process	glycosaminoglycan biosynthetic process
H	0006065	biological_process	UDP-glucuronate biosynthetic process
H	0009792	biological_process	embryo development ending in birth or egg hatching
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0018991	biological_process	egg-laying behavior
H	0040025	biological_process	vulval development
H	0042802	molecular_function	identical protein binding
H	0051287	molecular_function	NAD binding
I	0002009	biological_process	morphogenesis of an epithelium
I	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0006024	biological_process	glycosaminoglycan biosynthetic process
I	0006065	biological_process	UDP-glucuronate biosynthetic process
I	0009792	biological_process	embryo development ending in birth or egg hatching
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0018991	biological_process	egg-laying behavior
I	0040025	biological_process	vulval development
I	0042802	molecular_function	identical protein binding
I	0051287	molecular_function	NAD binding
J	0002009	biological_process	morphogenesis of an epithelium
J	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006024	biological_process	glycosaminoglycan biosynthetic process
J	0006065	biological_process	UDP-glucuronate biosynthetic process
J	0009792	biological_process	embryo development ending in birth or egg hatching
J	0016491	molecular_function	oxidoreductase activity
J	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J	0018991	biological_process	egg-laying behavior
J	0040025	biological_process	vulval development
J	0042802	molecular_function	identical protein binding
J	0051287	molecular_function	NAD binding
K	0002009	biological_process	morphogenesis of an epithelium
K	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006024	biological_process	glycosaminoglycan biosynthetic process
K	0006065	biological_process	UDP-glucuronate biosynthetic process
K	0009792	biological_process	embryo development ending in birth or egg hatching
K	0016491	molecular_function	oxidoreductase activity
K	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K	0018991	biological_process	egg-laying behavior
K	0040025	biological_process	vulval development
K	0042802	molecular_function	identical protein binding
K	0051287	molecular_function	NAD binding
L	0002009	biological_process	morphogenesis of an epithelium
L	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0006024	biological_process	glycosaminoglycan biosynthetic process
L	0006065	biological_process	UDP-glucuronate biosynthetic process
L	0009792	biological_process	embryo development ending in birth or egg hatching
L	0016491	molecular_function	oxidoreductase activity
L	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L	0018991	biological_process	egg-laying behavior
L	0040025	biological_process	vulval development
L	0042802	molecular_function	identical protein binding
L	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue UDX A 500

Chain	Residue
A	GLY16
A	THR96
A	TYR113
A	SER135
A	THR136
A	SER282
A	LYS286
A	ARG353
A	HOH604
A	HOH619
A	HOH635
A	GLY18
A	HOH667
A	TYR19
A	VAL20
A	ASP41
A	MET42
A	LYS46
A	VAL94
A	ASN95

---

site_id	AC2
Number of Residues	22
Details	binding site for residue UDX A 501

Chain	Residue
A	GLU168
A	PHE169
A	LEU170
A	ALA171
A	GLU172
A	LYS227
A	ILE238
A	PHE272
A	LEU273
A	GLN274
A	SER276
A	PHE279
A	GLY280
A	CYS283
A	PHE284
A	PHE345
A	LYS346
A	ARG447
A	HOH620
A	HOH632
A	HOH637
B	ARG267

---

site_id	AC3
Number of Residues	16
Details	binding site for residue UDX B 500

Chain	Residue
B	GLY16
B	GLY18
B	TYR19
B	VAL20
B	ASP41
B	MET42
B	LYS46
B	VAL94
B	ASN95
B	THR96
B	SER135
B	THR136
B	SER282
B	ARG353
B	HOH642
B	HOH653

---

site_id	AC4
Number of Residues	21
Details	binding site for residue UDX B 501

Chain	Residue
A	ARG267
A	HOH656
B	GLU168
B	PHE169
B	LEU170
B	ALA171
B	GLU172
B	LYS227
B	ILE238
B	PHE272
B	LEU273
B	GLN274
B	SER276
B	PHE279
B	GLY280
B	CYS283
B	PHE284
B	PHE345
B	LYS346
B	ARG447
B	HOH617

---

site_id	AC5
Number of Residues	19
Details	binding site for residue UDX C 500

Chain	Residue
C	GLY16
C	GLY18
C	TYR19
C	VAL20
C	ASP41
C	MET42
C	LYS46
C	ASN95
C	THR96
C	TYR113
C	SER135
C	THR136
C	VAL137
C	SER282
C	ARG353
C	HOH604
C	HOH609
C	HOH618
C	HOH622

---

site_id	AC6
Number of Residues	21
Details	binding site for residue UDX C 501

Chain	Residue
C	PHE169
C	LEU170
C	ALA171
C	GLU172
C	LYS227
C	ILE238
C	PHE272
C	LEU273
C	GLN274
C	SER276
C	PHE279
C	GLY280
C	CYS283
C	PHE284
C	PHE345
C	LYS346
C	ARG447
C	HOH653
D	ARG267
D	HOH648
C	GLU168

---

site_id	AC7
Number of Residues	20
Details	binding site for residue UDX D 500

Chain	Residue
D	GLY18
D	TYR19
D	VAL20
D	ASP41
D	MET42
D	LYS46
D	VAL94
D	ASN95
D	THR96
D	TYR113
D	SER135
D	THR136
D	SER282
D	LYS286
D	ARG353
D	HOH610
D	HOH638
D	HOH645
D	HOH659
D	HOH666

---

site_id	AC8
Number of Residues	25
Details	binding site for residue UDX D 501

Chain	Residue
C	ARG267
D	GLU168
D	PHE169
D	LEU170
D	ALA171
D	GLU172
D	LYS227
D	ILE238
D	PHE272
D	LEU273
D	GLN274
D	SER276
D	PHE279
D	GLY280
D	CYS283
D	PHE284
D	PHE345
D	LYS346
D	ARG447
D	HOH608
D	HOH616
D	HOH643
D	HOH660
D	HOH661
D	HOH675

---

site_id	AC9
Number of Residues	17
Details	binding site for residue UDX E 500

Chain	Residue
E	GLY18
E	TYR19
E	VAL20
E	ASP41
E	MET42
E	LYS46
E	VAL94
E	ASN95
E	THR96
E	TYR113
E	SER135
E	THR136
E	SER282
E	ARG353
E	HOH622
E	HOH624
E	HOH638

---

site_id	AD1
Number of Residues	20
Details	binding site for residue UDX E 501

Chain	Residue
E	GLU168
E	PHE169
E	LEU170
E	ALA171
E	GLU172
E	LYS227
E	ILE238
E	PHE272
E	LEU273
E	GLN274
E	SER276
E	PHE279
E	GLY280
E	CYS283
E	PHE284
E	PHE345
E	LYS346
E	ARG447
E	HOH625
F	ARG267

---

site_id	AD2
Number of Residues	18
Details	binding site for residue UDX F 500

Chain	Residue
F	GLY16
F	GLY18
F	TYR19
F	VAL20
F	ASP41
F	MET42
F	LYS46
F	ASN95
F	THR96
F	TYR113
F	SER135
F	THR136
F	SER282
F	ARG353
F	HOH606
F	HOH621
F	HOH640
F	HOH661

---

site_id	AD3
Number of Residues	23
Details	binding site for residue UDX F 501

Chain	Residue
E	ARG267
F	GLU168
F	PHE169
F	LEU170
F	ALA171
F	GLU172
F	LYS227
F	ILE238
F	PHE272
F	LEU273
F	GLN274
F	SER276
F	PHE279
F	GLY280
F	CYS283
F	PHE284
F	PHE345
F	LYS346
F	ARG447
F	HOH608
F	HOH611
F	HOH657
F	HOH669

---

site_id	AD4
Number of Residues	19
Details	binding site for residue UDX G 500

Chain	Residue
G	GLY16
G	GLY18
G	TYR19
G	VAL20
G	ASP41
G	MET42
G	LYS46
G	VAL94
G	ASN95
G	THR96
G	TYR113
G	SER135
G	THR136
G	SER282
G	LYS286
G	ARG353
G	HOH603
G	HOH630
G	HOH640

---

site_id	AD5
Number of Residues	22
Details	binding site for residue UDX G 501

Chain	Residue
G	GLU168
G	PHE169
G	LEU170
G	ALA171
G	GLU172
G	LYS227
G	ILE238
G	PHE272
G	LEU273
G	GLN274
G	SER276
G	PHE279
G	GLY280
G	CYS283
G	PHE284
G	PHE345
G	LYS346
G	ARG447
G	HOH608
G	HOH612
G	HOH622
H	ARG267

---

site_id	AD6
Number of Residues	21
Details	binding site for residue UDX H 500

Chain	Residue
H	GLY16
H	GLY18
H	TYR19
H	VAL20
H	ASP41
H	MET42
H	LYS46
H	VAL94
H	ASN95
H	THR96
H	TYR113
H	SER135
H	THR136
H	SER282
H	ARG353
H	HOH607
H	HOH619
H	HOH622
H	HOH664
H	HOH667
H	HOH668

---

site_id	AD7
Number of Residues	24
Details	binding site for residue UDX H 501

Chain	Residue
G	ARG267
H	GLU168
H	PHE169
H	LEU170
H	ALA171
H	GLU172
H	LYS227
H	ILE238
H	PHE272
H	LEU273
H	GLN274
H	SER276
H	PHE279
H	GLY280
H	CYS283
H	PHE284
H	PHE345
H	LYS346
H	ARG447
H	HOH625
H	HOH634
H	HOH639
H	HOH643
H	HOH651

---

site_id	AD8
Number of Residues	16
Details	binding site for residue UDX I 500

Chain	Residue
I	GLY16
I	GLY18
I	TYR19
I	VAL20
I	ASP41
I	MET42
I	LYS46
I	VAL94
I	ASN95
I	THR96
I	TYR113
I	SER135
I	THR136
I	ARG353
I	HOH613
I	HOH620

---

site_id	AD9
Number of Residues	21
Details	binding site for residue UDX I 501

Chain	Residue
I	GLU168
I	PHE169
I	LEU170
I	ALA171
I	GLU172
I	LYS227
I	ILE238
I	PHE272
I	LEU273
I	GLN274
I	SER276
I	PHE279
I	GLY280
I	CYS283
I	PHE284
I	PHE345
I	LYS346
I	ARG447
I	HOH619
I	HOH623
J	ARG267

---

site_id	AE1
Number of Residues	13
Details	binding site for residue UDX J 500

Chain	Residue
J	GLY18
J	TYR19
J	VAL20
J	ASP41
J	MET42
J	LYS46
J	ASN95
J	THR96
J	SER135
J	THR136
J	SER282
J	ARG353
J	HOH608

---

site_id	AE2
Number of Residues	21
Details	binding site for residue UDX J 501

Chain	Residue
I	ARG267
J	THR136
J	GLU168
J	PHE169
J	LEU170
J	ALA171
J	GLU172
J	LYS227
J	ILE238
J	PHE272
J	LEU273
J	GLN274
J	SER276
J	PHE279
J	GLY280
J	CYS283
J	PHE284
J	PHE345
J	LYS346
J	ARG447
J	HOH604

---

site_id	AE3
Number of Residues	15
Details	binding site for residue UDX K 500

Chain	Residue
K	GLY16
K	GLY18
K	TYR19
K	VAL20
K	ASP41
K	MET42
K	LYS46
K	ASN95
K	THR96
K	TYR113
K	SER135
K	THR136
K	SER282
K	ARG353
K	HOH624

---

site_id	AE4
Number of Residues	23
Details	binding site for residue UDX K 501

Chain	Residue
K	GLU168
K	PHE169
K	LEU170
K	ALA171
K	GLU172
K	LYS227
K	ILE238
K	PHE272
K	GLN274
K	SER276
K	PHE279
K	GLY280
K	CYS283
K	PHE284
K	PHE345
K	LYS346
K	ARG447
K	HOH618
K	HOH623
K	HOH636
K	HOH652
K	HOH665
L	ARG267

---

site_id	AE5
Number of Residues	18
Details	binding site for residue UDX L 500

Chain	Residue
L	GLY16
L	GLY18
L	TYR19
L	VAL20
L	ASP41
L	MET42
L	LYS46
L	VAL94
L	ASN95
L	THR96
L	TYR113
L	SER135
L	THR136
L	SER282
L	LYS286
L	ARG353
L	HOH616
L	HOH635

---

site_id	AE6
Number of Residues	19
Details	binding site for residue UDX L 501

Chain	Residue
K	ARG267
L	GLU168
L	PHE169
L	LEU170
L	ALA171
L	GLU172
L	LYS227
L	ILE238
L	PHE272
L	LEU273
L	GLN274
L	SER276
L	PHE279
L	GLY280
L	CYS283
L	PHE284
L	PHE345
L	LYS346
L	ARG447

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"O60701","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	396
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O60701","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---