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6OIJ

Muscarinic acetylcholine receptor 1-G11 protein complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001501biological_processskeletal system development
A0001508biological_processaction potential
A0001664molecular_functionG protein-coupled receptor binding
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007507biological_processheart development
A0007603biological_processphototransduction, visible light
A0008217biological_processregulation of blood pressure
A0009649biological_processentrainment of circadian clock
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0030234molecular_functionenzyme regulator activity
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0032024biological_processpositive regulation of insulin secretion
A0045202cellular_componentsynapse
A0045634biological_processregulation of melanocyte differentiation
A0046872molecular_functionmetal ion binding
A0048066biological_processdevelopmental pigmentation
A0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
A0070062cellular_componentextracellular exosome
A0071467biological_processcellular response to pH
A0086100biological_processendothelin receptor signaling pathway
A0099105biological_procession channel modulating, G protein-coupled receptor signaling pathway
A1904888biological_processcranial skeletal system development
A1990806biological_processligand-gated ion channel signaling pathway
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0016020cellular_componentmembrane
R0016907molecular_functionG protein-coupled acetylcholine receptor activity
R0040012biological_processregulation of locomotion
R0046541biological_processsaliva secretion
R0050890biological_processcognition
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue IXO R 501
ChainResidue
RASP105
RTYR408
RTYR106
RSER109
RGLN110
RALA196
RPHE197
RTRP378
RTYR404
RCYS407

site_idAC2
Number of Residues3
Detailsbinding site for residue Y01 R 502
ChainResidue
RCYS205
RTHR206
RILE383

site_idAC3
Number of Residues5
Detailsbinding site for residue Y01 R 503
ChainResidue
RCYS69
RPRO139
RALA143
RILE146
RTRP150

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVmNLLLISFDRYFsV
ChainResidueDetails
RALA111-VAL127

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
RASP122-ALA142
ATHR186
RCYS421-CYS460
AALA331

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68

site_idSWS_FT_FI4
Number of Residues36
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC
ChainResidueDetails
RTYR85-THR95
RGLN165-GLN185
RCYS391-GLU397

site_idSWS_FT_FI5
Number of Residues25
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC
ChainResidueDetails
RLEU96-PHE121

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC
ChainResidueDetails
RALA143-TRP164

site_idSWS_FT_FI7
Number of Residues23
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC
ChainResidueDetails
RPRO186-TRP209

site_idSWS_FT_FI8
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC
ChainResidueDetails
RLEU367-PHE390

site_idSWS_FT_FI9
Number of Residues22
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC
ChainResidueDetails
RTHR398-LEU420

site_idSWS_FT_FI10
Number of Residues4
DetailsSITE: Subtype-specific residue that binds to snake venom muscarinic toxin 7 => ECO:0000269|PubMed:32646996
ChainResidueDetails
RGLU170
RLEU174
RGLU397
RGLU401

site_idSWS_FT_FI11
Number of Residues1
DetailsSITE: Binds to snake venom muscarinic toxin 7 => ECO:0000269|PubMed:32646996
ChainResidueDetails
RTHR172

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P12657
ChainResidueDetails
RTHR342

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000255
ChainResidueDetails
RTHR428
RTHR455

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000255
ChainResidueDetails
RSER451
RSER457

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
RGLN2
RGLN12

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PDB entries from 2024-07-24

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