6OIB
Crystal structure of human Sulfide Quinone Oxidoreductase in complex with coenzyme Q
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0048038 | molecular_function | quinone binding |
| A | 0070221 | biological_process | sulfide oxidation, using sulfide:quinone oxidoreductase |
| A | 0070224 | molecular_function | sulfide:quinone oxidoreductase activity |
| A | 0071949 | molecular_function | FAD binding |
| A | 0106436 | molecular_function | glutathione-dependent sulfide quinone oxidoreductase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0048038 | molecular_function | quinone binding |
| B | 0070221 | biological_process | sulfide oxidation, using sulfide:quinone oxidoreductase |
| B | 0070224 | molecular_function | sulfide:quinone oxidoreductase activity |
| B | 0071949 | molecular_function | FAD binding |
| B | 0106436 | molecular_function | glutathione-dependent sulfide quinone oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ARG411 |
| A | LEU412 |
| A | SER413 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | binding site for residue FAD A 502 |
| Chain | Residue |
| A | PRO84 |
| A | ARG117 |
| A | VAL118 |
| A | ALA144 |
| A | LEU145 |
| A | GLY146 |
| A | ASN169 |
| A | TYR170 |
| A | CYS201 |
| A | LYS207 |
| A | GLY335 |
| A | ASP336 |
| A | LYS344 |
| A | THR345 |
| A | ALA346 |
| A | ALA347 |
| A | PRO380 |
| A | LYS418 |
| A | UQ1504 |
| A | H2S505 |
| A | HOH604 |
| A | HOH605 |
| A | HOH630 |
| A | HOH642 |
| A | HOH653 |
| A | HOH674 |
| A | HOH681 |
| A | GLY52 |
| A | SER53 |
| A | GLY54 |
| A | GLU75 |
| A | PRO76 |
| A | GLN83 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue UQ1 A 503 |
| Chain | Residue |
| A | GLN247 |
| A | GLN251 |
| A | LEU255 |
| A | THR256 |
| A | VAL257 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue UQ1 A 504 |
| Chain | Residue |
| A | TYR82 |
| A | ALA347 |
| A | TYR376 |
| A | SER378 |
| A | LEU390 |
| A | GLU392 |
| A | MET422 |
| A | MET430 |
| A | TRP435 |
| A | FAD502 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue H2S A 505 |
| Chain | Residue |
| A | CYS201 |
| A | LYS207 |
| A | FAD502 |
| A | H2S506 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue H2S A 506 |
| Chain | Residue |
| A | GLY203 |
| A | CYS379 |
| A | H2S505 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue UQ1 B 501 |
| Chain | Residue |
| B | TYR82 |
| B | ALA346 |
| B | ALA347 |
| B | TYR376 |
| B | SER378 |
| B | PRO380 |
| B | GLU392 |
| B | MET422 |
| B | MET430 |
| B | TRP435 |
| B | PRO438 |
| B | FAD502 |
| site_id | AC8 |
| Number of Residues | 33 |
| Details | binding site for residue FAD B 502 |
| Chain | Residue |
| B | HOH615 |
| B | HOH624 |
| B | HOH628 |
| B | HOH647 |
| B | GLY50 |
| B | GLY52 |
| B | SER53 |
| B | GLY54 |
| B | GLU75 |
| B | PRO76 |
| B | GLN83 |
| B | PRO84 |
| B | THR87 |
| B | ARG117 |
| B | VAL118 |
| B | ALA144 |
| B | LEU145 |
| B | GLY146 |
| B | ASN169 |
| B | TYR170 |
| B | CYS201 |
| B | LYS207 |
| B | GLY335 |
| B | ASP336 |
| B | LYS344 |
| B | THR345 |
| B | ALA346 |
| B | ALA347 |
| B | PRO380 |
| B | LYS418 |
| B | UQ1501 |
| B | H2S503 |
| B | HOH612 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"30905673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22852582","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30905673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9R112","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9R112","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
