6OHS
Structure of compound 3 (ML299) bound human Phospholipase D2 catalytic domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004630 | molecular_function | phospholipase D activity |
| A | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004630 | molecular_function | phospholipase D activity |
| B | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| B | 0035556 | biological_process | intracellular signal transduction |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004630 | molecular_function | phospholipase D activity |
| C | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| C | 0035556 | biological_process | intracellular signal transduction |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004630 | molecular_function | phospholipase D activity |
| D | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| D | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue MJY A 1001 |
| Chain | Residue |
| A | TRP364 |
| A | TRP519 |
| A | TRP540 |
| A | GLN642 |
| A | PHE643 |
| A | GLY686 |
| A | TYR754 |
| A | ASN773 |
| A | ARG777 |
| A | ASP784 |
| A | TRP365 |
| A | LEU409 |
| A | GLY410 |
| A | ILE411 |
| A | HIS442 |
| A | ARG464 |
| A | LEU514 |
| A | ASP518 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue MJY B 1001 |
| Chain | Residue |
| B | TRP364 |
| B | TRP365 |
| B | LEU409 |
| B | GLY410 |
| B | ALA440 |
| B | HIS442 |
| B | ARG464 |
| B | LEU514 |
| B | TRP519 |
| B | TRP540 |
| B | GLN642 |
| B | PHE643 |
| B | GLY686 |
| B | TYR754 |
| B | ASN773 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue MJY C 1001 |
| Chain | Residue |
| C | TRP364 |
| C | TRP365 |
| C | LEU409 |
| C | GLY410 |
| C | ILE411 |
| C | HIS442 |
| C | ARG464 |
| C | LEU514 |
| C | ASP518 |
| C | TRP519 |
| C | TRP540 |
| C | GLN642 |
| C | PHE687 |
| C | TYR754 |
| C | ASN773 |
| C | ASP784 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue MJY D 1001 |
| Chain | Residue |
| D | TRP364 |
| D | TRP365 |
| D | PHE402 |
| D | LEU409 |
| D | ALA440 |
| D | HIS442 |
| D | ARG464 |
| D | LEU514 |
| D | ASP518 |
| D | TRP519 |
| D | TRP540 |
| D | GLN642 |
| D | PHE643 |
| D | GLY686 |
| D | PHE687 |
| D | TYR754 |
| D | ASN773 |
| D | ARG777 |
| D | ASP784 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | Domain: {"description":"PLD phosphodiesterase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 108 |
| Details | Domain: {"description":"PLD phosphodiesterase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00153","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
