6OH4
X-ray crystal structure of the mouse CMP-sialic acid transporter in complex with CMP, by hanging drop vapor diffusion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005456 | molecular_function | CMP-N-acetylneuraminate transmembrane transporter activity |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0015165 | molecular_function | pyrimidine nucleotide-sugar transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015782 | biological_process | CMP-N-acetylneuraminate transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0071702 | biological_process | obsolete organic substance transport |
| A | 0090481 | biological_process | pyrimidine nucleotide-sugar transmembrane transport |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0005456 | molecular_function | CMP-N-acetylneuraminate transmembrane transporter activity |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0015165 | molecular_function | pyrimidine nucleotide-sugar transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015782 | biological_process | CMP-N-acetylneuraminate transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0071702 | biological_process | obsolete organic substance transport |
| B | 0090481 | biological_process | pyrimidine nucleotide-sugar transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue C5P A 401 |
| Chain | Residue |
| A | LYS55 |
| A | TYR214 |
| A | GLY257 |
| A | SER261 |
| A | LYS272 |
| A | TYR98 |
| A | GLN101 |
| A | ASN102 |
| A | TYR121 |
| A | LYS124 |
| A | SER188 |
| A | PHE195 |
| A | ASN210 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue C5P B 401 |
| Chain | Residue |
| B | LYS55 |
| B | TYR98 |
| B | GLN101 |
| B | ASN102 |
| B | TYR121 |
| B | LYS124 |
| B | SER188 |
| B | PHE195 |
| B | ASN210 |
| B | MET213 |
| B | TYR214 |
| B | GLY257 |
| B | SER261 |
| B | LYS272 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10085119, ECO:0000269|PubMed:30985278 |
| Chain | Residue | Details |
| A | MET1-SER9 | |
| A | PRO316-VAL336 | |
| B | MET1-SER9 | |
| B | PRO316-VAL336 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 376 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30985278 |
| Chain | Residue | Details |
| A | LEU10-ALA30 | |
| A | LEU297-LEU315 | |
| B | LEU10-ALA30 | |
| B | THR46-ALA64 | |
| B | LEU88-ALA108 | |
| B | ALA115-MET135 | |
| B | LYS142-TRP160 | |
| B | LEU176-GLU196 | |
| B | ASN210-SER228 | |
| B | TYR244-VAL262 | |
| B | ILE270-VAL288 | |
| A | THR46-ALA64 | |
| B | LEU297-LEU315 | |
| A | LEU88-ALA108 | |
| A | ALA115-MET135 | |
| A | LYS142-TRP160 | |
| A | LEU176-GLU196 | |
| A | ASN210-SER228 | |
| A | TYR244-VAL262 | |
| A | ILE270-VAL288 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:30985278 |
| Chain | Residue | Details |
| A | LEU31-THR45 | |
| B | LEU289-THR296 | |
| A | LEU109-ALA114 | |
| A | LYS161-LEU175 | |
| A | ASP229-THR243 | |
| A | LEU289-THR296 | |
| B | LEU31-THR45 | |
| B | LEU109-ALA114 | |
| B | LYS161-LEU175 | |
| B | ASP229-THR243 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 90 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30985278 |
| Chain | Residue | Details |
| A | LYS65-GLU87 | |
| A | LEU136-SER141 | |
| A | LYS197-ARG209 | |
| A | VAL263-ASN269 | |
| B | LYS65-GLU87 | |
| B | LEU136-SER141 | |
| B | LYS197-ARG209 | |
| B | VAL263-ASN269 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30985278, ECO:0007744|PDB:6OH2, ECO:0007744|PDB:6OH3 |
| Chain | Residue | Details |
| A | LYS55 | |
| B | SER188 | |
| B | ASN210 | |
| B | LYS272 | |
| A | GLN101 | |
| A | TYR117 | |
| A | SER188 | |
| A | ASN210 | |
| A | LYS272 | |
| B | LYS55 | |
| B | GLN101 | |
| B | TYR117 |
