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6OCH

Crystal structure of VASH1-SVBP complex bound with parthenolide

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0045765biological_processregulation of angiogenesis
C0005737cellular_componentcytoplasm
C0045765biological_processregulation of angiogenesis
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue M4Y A 401
ChainResidue
ATYR134
ALYS168
ACYS169
AARG203
AMET220
ASER221
AARG222
ALEU226

site_idAC2
Number of Residues6
Detailsbinding site for residue GOL A 402
ChainResidue
AVAL263
ASER264
AHIS265
AHOH510
AHOH565
AGLU187

site_idAC3
Number of Residues10
Detailsbinding site for residue SO4 A 403
ChainResidue
ALYS146
ASER192
AARG203
ALYS258
ALYS276
AHOH553
AHOH554
AHOH612
AHOH671
CASP100

site_idAC4
Number of Residues5
Detailsbinding site for residue SO4 A 404
ChainResidue
AARG76
AGLY286
AARG287
AHOH517
AHOH611

site_idAC5
Number of Residues5
Detailsbinding site for residue SO4 A 405
ChainResidue
ALYS194
AARG203
ALYS256
ALYS258
AHOH594

site_idAC6
Number of Residues4
Detailsbinding site for residue SO4 C 402
ChainResidue
CLYS194
CARG203
CLYS256
CLYS258

site_idAC7
Number of Residues8
Detailsbinding site for residue SO4 C 403
ChainResidue
CLYS146
CSER192
CARG203
CLYS258
CLYS276
CHOH506
CHOH512
CHOH656

site_idAC8
Number of Residues3
Detailsbinding site for residue SO4 C 404
ChainResidue
CVAL62
CARG64
CASP288

site_idAC9
Number of Residues13
Detailsbinding site for Di-peptide M4Y C 401 and CYS C 169
ChainResidue
CTYR134
CLYS168
CLEU170
CGLU171
CALA172
CVAL173
CPHE202
CARG203
CHIS204
CILE205
CMET220
CSER221
CHOH575

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:29146869, ECO:0000305|PubMed:26794318
ChainResidueDetails
ACYS169
CCYS169

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:26794318
ChainResidueDetails
AHIS204
ASER221
CHIS204
CSER221

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage => ECO:0000305|PubMed:16488400
ChainResidueDetails
AARG76
CARG76

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PDB entries from 2024-11-13

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