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6OB6

Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned

Functional Information from GO Data
ChainGOidnamespacecontents
A0001504biological_processneurotransmitter uptake
A0005326molecular_functionneurotransmitter transmembrane transporter activity
A0005337molecular_functionnucleoside transmembrane transporter activity
A0005886cellular_componentplasma membrane
A0006139biological_processnucleobase-containing compound metabolic process
A0006805biological_processxenobiotic metabolic process
A0006836biological_processneurotransmitter transport
A0006855biological_processxenobiotic transmembrane transport
A0007595biological_processlactation
A0015207molecular_functionadenine transmembrane transporter activity
A0015208molecular_functionguanine transmembrane transporter activity
A0015210molecular_functionuracil transmembrane transporter activity
A0015211molecular_functionpurine nucleoside transmembrane transporter activity
A0015212molecular_functioncytidine transmembrane transporter activity
A0015213molecular_functionuridine transmembrane transporter activity
A0015389molecular_functionpyrimidine- and adenosine-specific:sodium symporter activity
A0015851biological_processnucleobase transport
A0015853biological_processadenine transport
A0015858biological_processnucleoside transport
A0015860biological_processpurine nucleoside transmembrane transport
A0015861biological_processcytidine transport
A0015862biological_processuridine transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0032238biological_processadenosine transport
A0035340biological_processinosine transport
A0035344biological_processhypoxanthine transport
A0035364biological_processthymine transport
A0060079biological_processexcitatory postsynaptic potential
A0071333biological_processcellular response to glucose stimulus
A0071456biological_processcellular response to hypoxia
A0072531biological_processpyrimidine-containing compound transmembrane transport
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0150104biological_processtransport across blood-brain barrier
A1901642biological_processnucleoside transmembrane transport
A1903716biological_processguanine transmembrane transport
A1903791biological_processuracil transmembrane transport
A1904082biological_processpyrimidine nucleobase transmembrane transport
A1904823biological_processpurine nucleobase transmembrane transport
B0001504biological_processneurotransmitter uptake
B0005326molecular_functionneurotransmitter transmembrane transporter activity
B0005337molecular_functionnucleoside transmembrane transporter activity
B0005886cellular_componentplasma membrane
B0006139biological_processnucleobase-containing compound metabolic process
B0006805biological_processxenobiotic metabolic process
B0006836biological_processneurotransmitter transport
B0006855biological_processxenobiotic transmembrane transport
B0007595biological_processlactation
B0015207molecular_functionadenine transmembrane transporter activity
B0015208molecular_functionguanine transmembrane transporter activity
B0015210molecular_functionuracil transmembrane transporter activity
B0015211molecular_functionpurine nucleoside transmembrane transporter activity
B0015212molecular_functioncytidine transmembrane transporter activity
B0015213molecular_functionuridine transmembrane transporter activity
B0015389molecular_functionpyrimidine- and adenosine-specific:sodium symporter activity
B0015851biological_processnucleobase transport
B0015853biological_processadenine transport
B0015858biological_processnucleoside transport
B0015860biological_processpurine nucleoside transmembrane transport
B0015861biological_processcytidine transport
B0015862biological_processuridine transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0032238biological_processadenosine transport
B0035340biological_processinosine transport
B0035344biological_processhypoxanthine transport
B0035364biological_processthymine transport
B0060079biological_processexcitatory postsynaptic potential
B0071333biological_processcellular response to glucose stimulus
B0071456biological_processcellular response to hypoxia
B0072531biological_processpyrimidine-containing compound transmembrane transport
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0150104biological_processtransport across blood-brain barrier
B1901642biological_processnucleoside transmembrane transport
B1903716biological_processguanine transmembrane transport
B1903791biological_processuracil transmembrane transport
B1904082biological_processpyrimidine nucleobase transmembrane transport
B1904823biological_processpurine nucleobase transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue NBM A 501
ChainResidue
AGLY24
ATHR303
AILE304
APHE337
AASP341
AARG345
ATHR25
ALEU26
ATRP29
ALEU92
AILE119
AGLY154
ALEU157
AGLN158

site_idAC2
Number of Residues14
Detailsbinding site for residue NBM B 501
ChainResidue
BTHR25
BLEU26
BTRP29
BLEU92
BILE119
BGLY154
BLEU157
BGLN158
BPHE300
BTHR303
BILE304
BPHE337
BASP341
BARG345

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues152
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:11584005
ChainResidueDetails
ATHR2-LYS12
AGLN108-ARG111
AARG228-THR323
BTHR2-LYS12
BGLN108-ARG111
BARG228-THR323

site_idSWS_FT_FI2
Number of Residues428
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA13-TRP29
AVAL83-PRO107
AILE112-VAL130
APHE139-LEU157
AALA175-SER199
AGLY207-PRO227
ATRP324-LEU343
ALYS356-LEU374
AHIS392-LEU410
AGLU426-GLY445
BALA13-TRP29
BVAL83-PRO107
BILE112-VAL130
BPHE139-LEU157
BALA175-SER199
BGLY207-PRO227
BTRP324-LEU343
BLYS356-LEU374
BHIS392-LEU410
BGLU426-GLY445

site_idSWS_FT_FI3
Number of Residues186
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:11584005
ChainResidueDetails
AASN30-ASN82
ALYS131-PRO138
AGLU200-PHE206
AGLY344-GLY355
AALA411-ALA425
BASN30-ASN82
BLYS131-PRO138
BGLU200-PHE206
BGLY344-GLY355
BALA411-ALA425

site_idSWS_FT_FI4
Number of Residues98
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AALA446-VAL463
BGLN158-ALA174
BLEU375-GLU391
BALA446-VAL463
AGLN158-ALA174
ALEU375-GLU391

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Not glycosylated => ECO:0000269|PubMed:11584005
ChainResidueDetails
BALA309
BGLY320
AALA309
AGLY320

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Essential for nucleobase transport => ECO:0000269|PubMed:21795683
ChainResidueDetails
AALA446
BALA446

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU286
ATHR301
AGLY305
BLEU286
BTHR301
BGLY305

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11584005, ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN48
BASN48

221051

PDB entries from 2024-06-12

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