Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6OB6

Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001504	biological_process	neurotransmitter uptake
A	0005326	molecular_function	neurotransmitter transmembrane transporter activity
A	0005337	molecular_function	nucleoside transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0006836	biological_process	neurotransmitter transport
A	0006855	biological_process	xenobiotic transmembrane transport
A	0007595	biological_process	lactation
A	0015207	molecular_function	adenine transmembrane transporter activity
A	0015208	molecular_function	guanine transmembrane transporter activity
A	0015210	molecular_function	uracil transmembrane transporter activity
A	0015211	molecular_function	purine nucleoside transmembrane transporter activity
A	0015212	molecular_function	cytidine transmembrane transporter activity
A	0015213	molecular_function	uridine transmembrane transporter activity
A	0015389	molecular_function	pyrimidine- and adenosine-specific:sodium symporter activity
A	0015851	biological_process	nucleobase transport
A	0015853	biological_process	adenine transport
A	0015858	biological_process	nucleoside transport
A	0015860	biological_process	purine nucleoside transmembrane transport
A	0015861	biological_process	cytidine transport
A	0015862	biological_process	uridine transmembrane transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0032238	biological_process	adenosine transport
A	0035340	biological_process	inosine transport
A	0035344	biological_process	hypoxanthine transport
A	0035364	biological_process	thymine transport
A	0060079	biological_process	excitatory postsynaptic potential
A	0071333	biological_process	cellular response to glucose stimulus
A	0071456	biological_process	cellular response to hypoxia
A	0072531	biological_process	pyrimidine-containing compound transmembrane transport
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0150104	biological_process	transport across blood-brain barrier
A	1901642	biological_process	nucleoside transmembrane transport
A	1903716	biological_process	guanine transmembrane transport
A	1903791	biological_process	uracil transmembrane transport
A	1904082	biological_process	pyrimidine nucleobase transmembrane transport
A	1904823	biological_process	purine nucleobase transmembrane transport
B	0001504	biological_process	neurotransmitter uptake
B	0005326	molecular_function	neurotransmitter transmembrane transporter activity
B	0005337	molecular_function	nucleoside transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0006836	biological_process	neurotransmitter transport
B	0006855	biological_process	xenobiotic transmembrane transport
B	0007595	biological_process	lactation
B	0015207	molecular_function	adenine transmembrane transporter activity
B	0015208	molecular_function	guanine transmembrane transporter activity
B	0015210	molecular_function	uracil transmembrane transporter activity
B	0015211	molecular_function	purine nucleoside transmembrane transporter activity
B	0015212	molecular_function	cytidine transmembrane transporter activity
B	0015213	molecular_function	uridine transmembrane transporter activity
B	0015389	molecular_function	pyrimidine- and adenosine-specific:sodium symporter activity
B	0015851	biological_process	nucleobase transport
B	0015853	biological_process	adenine transport
B	0015858	biological_process	nucleoside transport
B	0015860	biological_process	purine nucleoside transmembrane transport
B	0015861	biological_process	cytidine transport
B	0015862	biological_process	uridine transmembrane transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0032238	biological_process	adenosine transport
B	0035340	biological_process	inosine transport
B	0035344	biological_process	hypoxanthine transport
B	0035364	biological_process	thymine transport
B	0060079	biological_process	excitatory postsynaptic potential
B	0071333	biological_process	cellular response to glucose stimulus
B	0071456	biological_process	cellular response to hypoxia
B	0072531	biological_process	pyrimidine-containing compound transmembrane transport
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0150104	biological_process	transport across blood-brain barrier
B	1901642	biological_process	nucleoside transmembrane transport
B	1903716	biological_process	guanine transmembrane transport
B	1903791	biological_process	uracil transmembrane transport
B	1904082	biological_process	pyrimidine nucleobase transmembrane transport
B	1904823	biological_process	purine nucleobase transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue NBM A 501

Chain	Residue
A	GLY24
A	THR303
A	ILE304
A	PHE337
A	ASP341
A	ARG345
A	THR25
A	LEU26
A	TRP29
A	LEU92
A	ILE119
A	GLY154
A	LEU157
A	GLN158

site_id	AC2
Number of Residues	14
Details	binding site for residue NBM B 501

Chain	Residue
B	THR25
B	LEU26
B	TRP29
B	LEU92
B	ILE119
B	GLY154
B	LEU157
B	GLN158
B	PHE300
B	THR303
B	ILE304
B	PHE337
B	ASP341
B	ARG345

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	54
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	82
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Essential for nucleobase transport","evidences":[{"source":"PubMed","id":"21795683","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)