Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6O9M

Structure of the human apo TFIIH

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000166	molecular_function	nucleotide binding
0	0000439	cellular_component	transcription factor TFIIH core complex
0	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0	0001666	biological_process	response to hypoxia
0	0001701	biological_process	in utero embryonic development
0	0003676	molecular_function	nucleic acid binding
0	0003677	molecular_function	DNA binding
0	0003678	molecular_function	DNA helicase activity
0	0003684	molecular_function	damaged DNA binding
0	0004386	molecular_function	helicase activity
0	0005515	molecular_function	protein binding
0	0005524	molecular_function	ATP binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005669	cellular_component	transcription factor TFIID complex
0	0005675	cellular_component	transcription factor TFIIH holo complex
0	0005737	cellular_component	cytoplasm
0	0005819	cellular_component	spindle
0	0005829	cellular_component	cytosol
0	0005856	cellular_component	cytoskeleton
0	0006139	biological_process	nucleobase-containing compound metabolic process
0	0006281	biological_process	DNA repair
0	0006283	biological_process	transcription-coupled nucleotide-excision repair
0	0006289	biological_process	nucleotide-excision repair
0	0006351	biological_process	DNA-templated transcription
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006362	biological_process	transcription elongation by RNA polymerase I
0	0006366	biological_process	transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0006915	biological_process	apoptotic process
0	0006974	biological_process	DNA damage response
0	0006979	biological_process	response to oxidative stress
0	0007059	biological_process	chromosome segregation
0	0008340	biological_process	determination of adult lifespan
0	0009411	biological_process	response to UV
0	0009650	biological_process	UV protection
0	0009791	biological_process	post-embryonic development
0	0016787	molecular_function	hydrolase activity
0	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
0	0016853	molecular_function	isomerase activity
0	0016887	molecular_function	ATP hydrolysis activity
0	0021510	biological_process	spinal cord development
0	0022405	biological_process	hair cycle process
0	0030198	biological_process	extracellular matrix organization
0	0030282	biological_process	bone mineralization
0	0030674	molecular_function	protein-macromolecule adaptor activity
0	0032289	biological_process	central nervous system myelin formation
0	0035264	biological_process	multicellular organism growth
0	0035315	biological_process	hair cell differentiation
0	0040016	biological_process	embryonic cleavage
0	0042274	biological_process	ribosomal small subunit biogenesis
0	0043139	molecular_function	5'-3' DNA helicase activity
0	0043249	biological_process	erythrocyte maturation
0	0043588	biological_process	skin development
0	0045951	biological_process	positive regulation of mitotic recombination
0	0046872	molecular_function	metal ion binding
0	0048009	biological_process	insulin-like growth factor receptor signaling pathway
0	0048568	biological_process	embryonic organ development
0	0048820	biological_process	hair follicle maturation
0	0051536	molecular_function	iron-sulfur cluster binding
0	0051539	molecular_function	4 iron, 4 sulfur cluster binding
0	0060218	biological_process	hematopoietic stem cell differentiation
0	0070516	cellular_component	CAK-ERCC2 complex
0	0071425	biological_process	hematopoietic stem cell proliferation
0	0071817	cellular_component	MMXD complex
0	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
0	1901990	biological_process	regulation of mitotic cell cycle phase transition
1	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
1	0000439	cellular_component	transcription factor TFIIH core complex
1	0003682	molecular_function	chromatin binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005675	cellular_component	transcription factor TFIIH holo complex
1	0006281	biological_process	DNA repair
1	0006289	biological_process	nucleotide-excision repair
1	0006351	biological_process	DNA-templated transcription
1	0006360	biological_process	transcription by RNA polymerase I
1	0006366	biological_process	transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0006974	biological_process	DNA damage response
1	0009755	biological_process	hormone-mediated signaling pathway
1	0045893	biological_process	positive regulation of DNA-templated transcription
1	0046966	molecular_function	nuclear thyroid hormone receptor binding
2	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
2	0000439	cellular_component	transcription factor TFIIH core complex
2	0001671	molecular_function	ATPase activator activity
2	0003690	molecular_function	double-stranded DNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005669	cellular_component	transcription factor TFIID complex
2	0005675	cellular_component	transcription factor TFIIH holo complex
2	0006281	biological_process	DNA repair
2	0006289	biological_process	nucleotide-excision repair
2	0006366	biological_process	transcription by RNA polymerase II
2	0006974	biological_process	DNA damage response
2	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
2	0016607	cellular_component	nuclear speck
3	0000082	biological_process	G1/S transition of mitotic cell cycle
3	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
3	0000439	cellular_component	transcription factor TFIIH core complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005675	cellular_component	transcription factor TFIIH holo complex
3	0006281	biological_process	DNA repair
3	0006289	biological_process	nucleotide-excision repair
3	0006355	biological_process	regulation of DNA-templated transcription
3	0006357	biological_process	regulation of transcription by RNA polymerase II
3	0006367	biological_process	transcription initiation at RNA polymerase II promoter
3	0007512	biological_process	adult heart development
3	0008270	molecular_function	zinc ion binding
3	0021591	biological_process	ventricular system development
3	0043066	biological_process	negative regulation of apoptotic process
3	0045737	biological_process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
3	0046872	molecular_function	metal ion binding
3	0048661	biological_process	positive regulation of smooth muscle cell proliferation
3	0051592	biological_process	response to calcium ion
3	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
3	0070516	cellular_component	CAK-ERCC2 complex
3	0070985	cellular_component	transcription factor TFIIK complex
3	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
4	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
4	0000439	cellular_component	transcription factor TFIIH core complex
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005669	cellular_component	transcription factor TFIID complex
4	0005675	cellular_component	transcription factor TFIIH holo complex
4	0006281	biological_process	DNA repair
4	0006289	biological_process	nucleotide-excision repair
4	0006355	biological_process	regulation of DNA-templated transcription
4	0006366	biological_process	transcription by RNA polymerase II
4	0006974	biological_process	DNA damage response
4	0008270	molecular_function	zinc ion binding
4	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
4	0046872	molecular_function	metal ion binding
4	0097550	cellular_component	transcription preinitiation complex
5	0000439	cellular_component	transcription factor TFIIH core complex
5	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005669	cellular_component	transcription factor TFIID complex
5	0005675	cellular_component	transcription factor TFIIH holo complex
5	0005730	cellular_component	nucleolus
5	0005737	cellular_component	cytoplasm
5	0006281	biological_process	DNA repair
5	0006289	biological_process	nucleotide-excision repair
5	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
5	0006362	biological_process	transcription elongation by RNA polymerase I
5	0006366	biological_process	transcription by RNA polymerase II
5	0006367	biological_process	transcription initiation at RNA polymerase II promoter
5	0006974	biological_process	DNA damage response
5	0071480	biological_process	cellular response to gamma radiation
6	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
6	0000439	cellular_component	transcription factor TFIIH core complex
6	0002031	biological_process	G protein-coupled receptor internalization
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005669	cellular_component	transcription factor TFIID complex
6	0005675	cellular_component	transcription factor TFIIH holo complex
6	0006281	biological_process	DNA repair
6	0006289	biological_process	nucleotide-excision repair
6	0006351	biological_process	DNA-templated transcription
6	0006357	biological_process	regulation of transcription by RNA polymerase II
6	0006366	biological_process	transcription by RNA polymerase II
6	0006367	biological_process	transcription initiation at RNA polymerase II promoter
6	0006974	biological_process	DNA damage response
6	0008270	molecular_function	zinc ion binding
6	0009411	biological_process	response to UV
6	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
6	0016607	cellular_component	nuclear speck
6	0046872	molecular_function	metal ion binding
7	0000112	cellular_component	nucleotide-excision repair factor 3 complex
7	0000166	molecular_function	nucleotide binding
7	0000439	cellular_component	transcription factor TFIIH core complex
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003684	molecular_function	damaged DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005669	cellular_component	transcription factor TFIID complex
7	0005675	cellular_component	transcription factor TFIIH holo complex
7	0006265	biological_process	DNA topological change
7	0006281	biological_process	DNA repair
7	0006283	biological_process	transcription-coupled nucleotide-excision repair
7	0006289	biological_process	nucleotide-excision repair
7	0006366	biological_process	transcription by RNA polymerase II
7	0006367	biological_process	transcription initiation at RNA polymerase II promoter
7	0006368	biological_process	transcription elongation by RNA polymerase II
7	0006915	biological_process	apoptotic process
7	0006974	biological_process	DNA damage response
7	0006979	biological_process	response to oxidative stress
7	0008104	biological_process	protein localization
7	0009411	biological_process	response to UV
7	0009650	biological_process	UV protection
7	0016787	molecular_function	hydrolase activity
7	0016853	molecular_function	isomerase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0035315	biological_process	hair cell differentiation
7	0043065	biological_process	positive regulation of apoptotic process
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0048568	biological_process	embryonic organ development
7	0097550	cellular_component	transcription preinitiation complex
7	1901990	biological_process	regulation of mitotic cell cycle phase transition
7	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SF4 0 801

Chain	Residue
0	LEU115
0	CYS116
0	HIS118
0	CYS134
0	CYS155
0	PHE157
0	CYS190
0	PHE193
0	ARG299

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN 3 401

Chain	Residue
3	CYS6
3	CYS9
3	THR12
3	CYS31
3	CYS34

site_id	AC3
Number of Residues	2
Details	binding site for residue ZN 3 402

Chain	Residue
3	CYS26
3	THR51

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN 4 401

Chain	Residue
4	CYS268
4	SER269
4	CYS271
4	SER273
4	THR284

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN 6 401

Chain	Residue
6	CYS345
6	PHE367
6	CYS368
6	CYS371

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN 6 402

Chain	Residue
6	CYS363
6	CYS382
6	GLY384
6	CYS385

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN 6 403

Chain	Residue
1	ARG473
6	GLN293
6	CYS294
6	CYS308

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
6	CYS360-HIS380

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV

Chain	Residue	Details
3	CYS26-VAL35

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
0	ALA229-ASN238

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	199
Details	Region: {"description":"Mediates interaction with MMS19"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	52
Details	Domain: {"description":"BSD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00036","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBA9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	19
Details	Domain: {"description":"UIM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00213","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	44
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	34
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	176
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	161
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	160
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)