6O9B

Crystal structure of HLA-A3*01 in complex with a wild-type beta-catenin peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006955	biological_process	immune response
B	0042612	cellular_component	MHC class I protein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PG4 A 301

Chain	Residue
A	ARG21
B	SER53
B	ASP54

---

site_id	AC2
Number of Residues	11
Details	binding site for residue MES A 302

Chain	Residue
A	ARG273
A	TRP274
A	GLU275
A	HOH404
A	HOH421
A	ASN127
A	ASP129
A	ARG131
A	SER132
A	HIS188
A	MET189

---

site_id	AC3
Number of Residues	6
Details	binding site for residue IMD A 303

Chain	Residue
A	SER2
A	HIS3
A	ASP29
A	ARG181
A	THR182
A	GLU264

---

site_id	AC4
Number of Residues	1
Details	binding site for residue IMD A 304

Chain	Residue
A	GLU166

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PEG A 305

Chain	Residue
A	ARG6
A	TYR27
A	ASP29
A	ASP30
B	MES202

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PEG A 306

Chain	Residue
A	MET45
A	GLU53
A	TRP60

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO A 307

Chain	Residue
A	SER4

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 308

Chain	Residue
A	HIS192
A	THR200
A	ARG202
A	HOH457

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 309

Chain	Residue
A	GLY16

---

site_id	AD1
Number of Residues	1
Details	binding site for residue EDO A 310

Chain	Residue
A	TYR84

---

site_id	AD2
Number of Residues	7
Details	binding site for residue PG4 B 201

Chain	Residue
A	PHE8
A	MET98
A	ARG111
A	GLN115
B	SER77
B	LYS78
B	MES202

---

site_id	AD3
Number of Residues	9
Details	binding site for residue MES B 202

Chain	Residue
A	ALA211
A	PHE241
A	PEG305
B	TYR46
B	SER77
B	LYS78
B	TYR83
B	PG4201
B	MES203

---

site_id	AD4
Number of Residues	7
Details	binding site for residue MES B 203

Chain	Residue
A	GLU232
A	THR233
A	LYS243
A	HOH476
B	SER77
B	ASP79
B	MES202

---

site_id	AD5
Number of Residues	7
Details	binding site for residue PEG B 204

Chain	Residue
A	HIS188
A	TRP204
A	GLN242
B	SER31
B	ARG32
B	HIS33
B	PRO34

---

site_id	AD6
Number of Residues	2
Details	binding site for residue PEG B 205

Chain	Residue
B	ASN103
B	HIS104

---

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO B 206

Chain	Residue
B	GLU56
B	ASP58
B	ARG101
B	ASN103

---

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO B 207

Chain	Residue
B	LYS111

---

site_id	AD9
Number of Residues	1
Details	binding site for residue EDO B 208

Chain	Residue
B	SER108

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR98-HIS104

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	86
Details	Domain: {"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	89
Details	Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	91
Details	Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	91
Details	Region: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	88
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by GSK3-beta","evidences":[{"source":"PubMed","id":"12027456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30714168","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12051714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24824780","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---