Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004839 | molecular_function | ubiquitin activating enzyme activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0036211 | biological_process | protein modification process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004839 | molecular_function | ubiquitin activating enzyme activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0006974 | biological_process | DNA damage response |
| C | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0016874 | molecular_function | ligase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0036211 | biological_process | protein modification process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1101 |
| Chain | Residue |
| A | HIS305 |
| A | GLU320 |
| A | ASP715 |
| A | HIS717 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue TRS A 1102 |
| Chain | Residue |
| A | GLU553 |
| A | ARG919 |
| A | ASN921 |
| A | CYS1009 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue MPD A 1103 |
| Chain | Residue |
| A | TYR378 |
| A | THR175 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 1104 |
| Chain | Residue |
| A | GLN136 |
| A | SER161 |
| A | PHE295 |
| A | TYR385 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MPD A 1105 |
| Chain | Residue |
| A | GLU658 |
| A | GLU665 |
| A | MET668 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 1106 |
| Chain | Residue |
| A | ARG547 |
| A | VAL990 |
| A | GLU992 |
| A | PHE1007 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MPD A 1107 |
| Chain | Residue |
| A | ILE716 |
| A | HIS717 |
| A | GLU748 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue VMX A 1108 |
| Chain | Residue |
| A | ALA437 |
| A | ILE438 |
| A | ASP463 |
| A | MET464 |
| A | ASP465 |
| A | LYS487 |
| A | VAL513 |
| A | ALA535 |
| A | ASP537 |
| A | ASN538 |
| A | THR561 |
| A | CYS593 |
| B | GLY75 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 1101 |
| Chain | Residue |
| C | HIS305 |
| C | GLU320 |
| C | ASP715 |
| C | HIS717 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue TRS C 1102 |
| Chain | Residue |
| C | GLU553 |
| C | ARG919 |
| C | ASN921 |
| C | HIS988 |
| C | CYS1009 |
| C | LYS1011 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue MPD C 1103 |
| Chain | Residue |
| C | GLU658 |
| C | GLU665 |
| C | LEU672 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MPD C 1104 |
| Chain | Residue |
| C | ASP68 |
| C | PRO69 |
| C | GLN70 |
| C | GLU130 |
| C | THR131 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue MPD C 1105 |
| Chain | Residue |
| C | GLU577 |
| C | SER582 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue MPD C 1106 |
| Chain | Residue |
| C | ILE716 |
| C | PHE722 |
| C | GLU748 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MPD C 1107 |
| Chain | Residue |
| C | LEU133 |
| C | GLN136 |
| C | SER161 |
| C | PHE295 |
| C | TYR385 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue MPD C 1108 |
| Chain | Residue |
| C | VAL990 |
| C | GLU992 |
| C | PHE1007 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KskIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 | |
| site_id | PS00865 |
| Number of Residues | 9 |
| Details | UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PICTLKnFP |
| Chain | Residue | Details |
| A | PRO591-PRO599 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| B | LYS6 | |
| B | LYS11 | |
| B | LYS27 | |
| B | LYS33 | |
| D | LYS6 | |
| D | LYS11 | |
| D | LYS27 | |
| D | LYS33 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG22 | |
| C | LYS487 | |
| C | VAL513 | |
| C | ASP537 | |
| B | LYS29 | |
| B | LYS48 | |
| B | LYS63 | |
| A | VAL513 | |
| D | LYS29 | |
| D | LYS48 | |
| D | LYS63 | |
| C | ASP463 | |
| Chain | Residue | Details |
| A | ARG474 | |
| C | ARG474 | |
