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6O81

Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0002183biological_processcytoplasmic translational initiation
A0003743molecular_functiontranslation initiation factor activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005851cellular_componenteukaryotic translation initiation factor 2B complex
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0009408biological_processresponse to heat
A0009749biological_processresponse to glucose
A0014002biological_processastrocyte development
A0014003biological_processoligodendrocyte development
A0021766biological_processhippocampus development
A0031369molecular_functiontranslation initiation factor binding
A0034976biological_processresponse to endoplasmic reticulum stress
A0042552biological_processmyelination
A0043065biological_processpositive regulation of apoptotic process
A0043434biological_processresponse to peptide hormone
A0045727biological_processpositive regulation of translation
A0045948biological_processpositive regulation of translational initiation
A0048708biological_processastrocyte differentiation
A0050852biological_processT cell receptor signaling pathway
B0001541biological_processovarian follicle development
B0002183biological_processcytoplasmic translational initiation
B0003743molecular_functiontranslation initiation factor activity
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005851cellular_componenteukaryotic translation initiation factor 2B complex
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0009408biological_processresponse to heat
B0009749biological_processresponse to glucose
B0014002biological_processastrocyte development
B0014003biological_processoligodendrocyte development
B0021766biological_processhippocampus development
B0031369molecular_functiontranslation initiation factor binding
B0034976biological_processresponse to endoplasmic reticulum stress
B0042552biological_processmyelination
B0043065biological_processpositive regulation of apoptotic process
B0043434biological_processresponse to peptide hormone
B0045727biological_processpositive regulation of translation
B0045948biological_processpositive regulation of translational initiation
B0048708biological_processastrocyte differentiation
B0050852biological_processT cell receptor signaling pathway
C0001541biological_processovarian follicle development
C0002183biological_processcytoplasmic translational initiation
C0003743molecular_functiontranslation initiation factor activity
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005851cellular_componenteukaryotic translation initiation factor 2B complex
C0006412biological_processtranslation
C0006413biological_processtranslational initiation
C0006446biological_processregulation of translational initiation
C0007417biological_processcentral nervous system development
C0009408biological_processresponse to heat
C0009749biological_processresponse to glucose
C0014003biological_processoligodendrocyte development
C0042552biological_processmyelination
C0043434biological_processresponse to peptide hormone
C0044237biological_processcellular metabolic process
C0050852biological_processT cell receptor signaling pathway
D0001541biological_processovarian follicle development
D0002183biological_processcytoplasmic translational initiation
D0003743molecular_functiontranslation initiation factor activity
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005851cellular_componenteukaryotic translation initiation factor 2B complex
D0006412biological_processtranslation
D0006413biological_processtranslational initiation
D0006446biological_processregulation of translational initiation
D0007417biological_processcentral nervous system development
D0009408biological_processresponse to heat
D0009749biological_processresponse to glucose
D0014003biological_processoligodendrocyte development
D0042552biological_processmyelination
D0043434biological_processresponse to peptide hormone
D0044237biological_processcellular metabolic process
D0050852biological_processT cell receptor signaling pathway
E0001541biological_processovarian follicle development
E0002183biological_processcytoplasmic translational initiation
E0003743molecular_functiontranslation initiation factor activity
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005851cellular_componenteukaryotic translation initiation factor 2B complex
E0006412biological_processtranslation
E0006413biological_processtranslational initiation
E0006417biological_processregulation of translation
E0009408biological_processresponse to heat
E0009749biological_processresponse to glucose
E0014003biological_processoligodendrocyte development
E0031369molecular_functiontranslation initiation factor binding
E0042552biological_processmyelination
E0043434biological_processresponse to peptide hormone
E0044237biological_processcellular metabolic process
E0050852biological_processT cell receptor signaling pathway
F0001541biological_processovarian follicle development
F0002183biological_processcytoplasmic translational initiation
F0003743molecular_functiontranslation initiation factor activity
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005851cellular_componenteukaryotic translation initiation factor 2B complex
F0006412biological_processtranslation
F0006413biological_processtranslational initiation
F0006417biological_processregulation of translation
F0009408biological_processresponse to heat
F0009749biological_processresponse to glucose
F0014003biological_processoligodendrocyte development
F0031369molecular_functiontranslation initiation factor binding
F0042552biological_processmyelination
F0043434biological_processresponse to peptide hormone
F0044237biological_processcellular metabolic process
F0050852biological_processT cell receptor signaling pathway
G0002183biological_processcytoplasmic translational initiation
G0003743molecular_functiontranslation initiation factor activity
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005851cellular_componenteukaryotic translation initiation factor 2B complex
G0005886cellular_componentplasma membrane
G0006412biological_processtranslation
G0006413biological_processtranslational initiation
G0009408biological_processresponse to heat
G0009749biological_processresponse to glucose
G0014003biological_processoligodendrocyte development
G0016020cellular_componentmembrane
G0042802molecular_functionidentical protein binding
G0043434biological_processresponse to peptide hormone
G0044237biological_processcellular metabolic process
G0050852biological_processT cell receptor signaling pathway
H0002183biological_processcytoplasmic translational initiation
H0003743molecular_functiontranslation initiation factor activity
H0005085molecular_functionguanyl-nucleotide exchange factor activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005851cellular_componenteukaryotic translation initiation factor 2B complex
H0005886cellular_componentplasma membrane
H0006412biological_processtranslation
H0006413biological_processtranslational initiation
H0009408biological_processresponse to heat
H0009749biological_processresponse to glucose
H0014003biological_processoligodendrocyte development
H0016020cellular_componentmembrane
H0042802molecular_functionidentical protein binding
H0043434biological_processresponse to peptide hormone
H0044237biological_processcellular metabolic process
H0050852biological_processT cell receptor signaling pathway
I0002183biological_processcytoplasmic translational initiation
I0003743molecular_functiontranslation initiation factor activity
I0005085molecular_functionguanyl-nucleotide exchange factor activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005851cellular_componenteukaryotic translation initiation factor 2B complex
I0006412biological_processtranslation
I0006413biological_processtranslational initiation
I0008135molecular_functiontranslation factor activity, RNA binding
I0009058biological_processbiosynthetic process
I0009408biological_processresponse to heat
I0009749biological_processresponse to glucose
I0014003biological_processoligodendrocyte development
I0032045cellular_componentguanyl-nucleotide exchange factor complex
I0043434biological_processresponse to peptide hormone
I0050852biological_processT cell receptor signaling pathway
J0002183biological_processcytoplasmic translational initiation
J0003743molecular_functiontranslation initiation factor activity
J0005085molecular_functionguanyl-nucleotide exchange factor activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005851cellular_componenteukaryotic translation initiation factor 2B complex
J0006412biological_processtranslation
J0006413biological_processtranslational initiation
J0008135molecular_functiontranslation factor activity, RNA binding
J0009058biological_processbiosynthetic process
J0009408biological_processresponse to heat
J0009749biological_processresponse to glucose
J0014003biological_processoligodendrocyte development
J0032045cellular_componentguanyl-nucleotide exchange factor complex
J0043434biological_processresponse to peptide hormone
J0050852biological_processT cell receptor signaling pathway
L0000423biological_processmitophagy
L0003676molecular_functionnucleic acid binding
L0003723molecular_functionRNA binding
L0003743molecular_functiontranslation initiation factor activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005850cellular_componenteukaryotic translation initiation factor 2 complex
L0006412biological_processtranslation
L0006413biological_processtranslational initiation
L0006417biological_processregulation of translation
L0010494cellular_componentcytoplasmic stress granule
L0016020cellular_componentmembrane
L0032057biological_processnegative regulation of translational initiation in response to stress
L0033290cellular_componenteukaryotic 48S preinitiation complex
L0034063biological_processstress granule assembly
L0034198biological_processcellular response to amino acid starvation
L0034599biological_processcellular response to oxidative stress
L0034605biological_processcellular response to heat
L0034644biological_processcellular response to UV
L0034976biological_processresponse to endoplasmic reticulum stress
L0036490biological_processregulation of translation in response to endoplasmic reticulum stress
L0036499biological_processPERK-mediated unfolded protein response
L0043022molecular_functionribosome binding
L0043558biological_processregulation of translational initiation in response to stress
L0044207cellular_componenttranslation initiation ternary complex
L0045202cellular_componentsynapse
L0070062cellular_componentextracellular exosome
L0097451cellular_componentglial limiting end-foot
L0140468biological_processHRI-mediated signaling
L1904373biological_processresponse to kainic acid
L1990737biological_processresponse to manganese-induced endoplasmic reticulum stress
L2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
M0000423biological_processmitophagy
M0003676molecular_functionnucleic acid binding
M0003723molecular_functionRNA binding
M0003743molecular_functiontranslation initiation factor activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005850cellular_componenteukaryotic translation initiation factor 2 complex
M0006412biological_processtranslation
M0006413biological_processtranslational initiation
M0006417biological_processregulation of translation
M0010494cellular_componentcytoplasmic stress granule
M0016020cellular_componentmembrane
M0032057biological_processnegative regulation of translational initiation in response to stress
M0033290cellular_componenteukaryotic 48S preinitiation complex
M0034063biological_processstress granule assembly
M0034198biological_processcellular response to amino acid starvation
M0034599biological_processcellular response to oxidative stress
M0034605biological_processcellular response to heat
M0034644biological_processcellular response to UV
M0034976biological_processresponse to endoplasmic reticulum stress
M0036490biological_processregulation of translation in response to endoplasmic reticulum stress
M0036499biological_processPERK-mediated unfolded protein response
M0043022molecular_functionribosome binding
M0043558biological_processregulation of translational initiation in response to stress
M0044207cellular_componenttranslation initiation ternary complex
M0045202cellular_componentsynapse
M0070062cellular_componentextracellular exosome
M0097451cellular_componentglial limiting end-foot
M0140468biological_processHRI-mediated signaling
M1904373biological_processresponse to kainic acid
M1990737biological_processresponse to manganese-induced endoplasmic reticulum stress
M2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
S0000049molecular_functiontRNA binding
S0001731biological_processformation of translation preinitiation complex
S0002183biological_processcytoplasmic translational initiation
S0003743molecular_functiontranslation initiation factor activity
S0003924molecular_functionGTPase activity
S0005515molecular_functionprotein binding
S0005525molecular_functionGTP binding
S0005634cellular_componentnucleus
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0005850cellular_componenteukaryotic translation initiation factor 2 complex
S0006412biological_processtranslation
S0006413biological_processtranslational initiation
S0008135molecular_functiontranslation factor activity, RNA binding
S0016787molecular_functionhydrolase activity
S0045296molecular_functioncadherin binding
S0070062cellular_componentextracellular exosome
S1990856molecular_functionmethionyl-initiator methionine tRNA binding
T0000049molecular_functiontRNA binding
T0001731biological_processformation of translation preinitiation complex
T0002183biological_processcytoplasmic translational initiation
T0003743molecular_functiontranslation initiation factor activity
T0003924molecular_functionGTPase activity
T0005515molecular_functionprotein binding
T0005525molecular_functionGTP binding
T0005634cellular_componentnucleus
T0005737cellular_componentcytoplasm
T0005829cellular_componentcytosol
T0005850cellular_componenteukaryotic translation initiation factor 2 complex
T0006412biological_processtranslation
T0006413biological_processtranslational initiation
T0008135molecular_functiontranslation factor activity, RNA binding
T0016787molecular_functionhydrolase activity
T0045296molecular_functioncadherin binding
T0070062cellular_componentextracellular exosome
T1990856molecular_functionmethionyl-initiator methionine tRNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue C7B C 401
ChainResidue
CASN162
DILE190
DTHR215
DVAL225
EVAL177
ESER178
ELEU179
ELEU485
FVAL177
FSER178
FLEU179
CVAL164
FLEU485
CHIS188
CILE190
CTHR215
CVAL225
DASN162
DVAL164
DHIS188

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P32481
ChainResidueDetails
SALA51
SASN190
SSER225
TALA51
TASN190
TSER225

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylalanine; partial => ECO:0000269|Ref.8
ChainResidueDetails
SALA2
TALA2
FSER12
FSER130

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0N1
ChainResidueDetails
SSER16
TSER16
ASER532
ASER540
BSER27
BSER130
BSER532
BSER540

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
LSER157
MSER157

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
LTHR278
LTHR280
MTHR278
MTHR280
BSER466
BSER469

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by DYRK2 => ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER544
BSER544

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER717
BSER717

site_idSWS_FT_FI8
Number of Residues10
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350
ChainResidueDetails
ALYS61
BLYS217
ALYS103
ALYS141
ALYS217
BLYS61
BLYS103
BLYS141

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PDB entries from 2024-07-17

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