6O7E
Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with AMPPNP in type III-A CRISPR-Cas system
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051607 | biological_process | defense response to virus |
| B | 0003723 | molecular_function | RNA binding |
| B | 0051607 | biological_process | defense response to virus |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004519 | molecular_function | endonuclease activity |
| C | 0051607 | biological_process | defense response to virus |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004519 | molecular_function | endonuclease activity |
| D | 0051607 | biological_process | defense response to virus |
| E | 0003723 | molecular_function | RNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0051607 | biological_process | defense response to virus |
| Y | 0003723 | molecular_function | RNA binding |
| Y | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | CYS389 |
| A | CYS392 |
| A | CYS413 |
| A | CYS416 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue ANP A 802 |
| Chain | Residue |
| A | ARG524 |
| A | LEU525 |
| A | GLY526 |
| A | PHE529 |
| A | SER542 |
| A | GLY587 |
| A | ASP588 |
| A | LYS648 |
| A | ARG652 |
| A | MN804 |
| A | MN805 |
| E | TYR90 |
| E | LYS94 |
| A | PHE290 |
| A | ALA292 |
| A | HIS295 |
| A | VAL522 |
| A | ASP523 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue ANP A 803 |
| Chain | Residue |
| A | ASP239 |
| A | PHE240 |
| A | SER241 |
| A | GLY242 |
| A | ILE243 |
| A | GLN244 |
| A | ILE247 |
| A | SER263 |
| A | LEU266 |
| A | GLY293 |
| A | LYS367 |
| A | TYR584 |
| A | ASP589 |
| A | MN806 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 804 |
| Chain | Residue |
| A | ASP521 |
| A | ASP588 |
| A | ANP802 |
| A | MN805 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 805 |
| Chain | Residue |
| A | ASP521 |
| A | VAL522 |
| A | ASP588 |
| A | ANP802 |
| A | MN804 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue MN A 806 |
| Chain | Residue |
| A | ASP239 |
| A | PHE240 |
| A | ANP803 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | HIS111 |
| C | CYS113 |
| C | CYS122 |
| C | CYS125 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | HIS111 |
| D | CYS113 |
| D | CYS122 |
| D | CYS125 |
