6O72

Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue Y01 A 1301

Chain	Residue
A	TRP673
A	9PE1303
A	ILE687
A	PHE729
A	VAL733
A	ILE737
A	SER840
A	LEU843
A	ARG988
A	VAL992

---

site_id	AC2
Number of Residues	2
Details	binding site for residue UND A 1302

Chain	Residue
A	PHE691
A	9PE1303

---

site_id	AC3
Number of Residues	8
Details	binding site for residue 9PE A 1303

Chain	Residue
A	ILE737
A	PHE837
A	SER840
A	ARG841
A	LEU843
A	Y011301
A	UND1302
D	PHE862

---

site_id	AC4
Number of Residues	2
Details	binding site for residue UND A 1304

Chain	Residue
A	PHE864
D	TYR953

---

site_id	AC5
Number of Residues	11
Details	binding site for residue T14 A 1305

Chain	Residue
A	PHE729
A	TYR736
A	LEU769
A	ASN790
A	ASP793
A	ARG832
A	ILE836
A	VAL839
A	SER840
A	LEU843
A	TYR995

---

site_id	AC6
Number of Residues	1
Details	binding site for residue NA A 1307

Chain	Residue
A	THR957

---

site_id	AC7
Number of Residues	1
Details	binding site for residue UND A 1308

Chain	Residue
B	PHE864

---

site_id	AC8
Number of Residues	2
Details	binding site for residue UND B 1302

Chain	Residue
B	PHE691
B	9PE1303

---

site_id	AC9
Number of Residues	8
Details	binding site for residue 9PE B 1303

Chain	Residue
A	PHE862
B	ILE737
B	PHE837
B	SER840
B	ARG841
B	LEU843
B	Y011301
B	UND1302

---

site_id	AD1
Number of Residues	11
Details	binding site for residue T14 B 1304

Chain	Residue
B	PHE729
B	TYR736
B	LEU769
B	ASN790
B	ASP793
B	ARG832
B	ILE836
B	VAL839
B	SER840
B	LEU843
B	TYR995

---

site_id	AD2
Number of Residues	1
Details	binding site for residue NA B 1306

Chain	Residue
B	THR957

---

site_id	AD3
Number of Residues	2
Details	binding site for residue UND C 1302

Chain	Residue
C	PHE691
C	9PE1303

---

site_id	AD4
Number of Residues	8
Details	binding site for residue 9PE C 1303

Chain	Residue
B	PHE862
C	ILE737
C	PHE837
C	SER840
C	ARG841
C	LEU843
C	Y011301
C	UND1302

---

site_id	AD5
Number of Residues	1
Details	binding site for residue UND C 1304

Chain	Residue
C	PHE864

---

site_id	AD6
Number of Residues	11
Details	binding site for residue T14 C 1305

Chain	Residue
C	PHE729
C	TYR736
C	LEU769
C	ASN790
C	ASP793
C	ARG832
C	ILE836
C	VAL839
C	SER840
C	LEU843
C	TYR995

---

site_id	AD7
Number of Residues	1
Details	binding site for residue NA C 1307

Chain	Residue
C	THR957

---

site_id	AD8
Number of Residues	2
Details	binding site for residue UND D 1302

Chain	Residue
D	PHE691
D	9PE1303

---

site_id	AD9
Number of Residues	8
Details	binding site for residue 9PE D 1303

Chain	Residue
C	PHE862
D	ILE737
D	PHE837
D	SER840
D	ARG841
D	LEU843
D	Y011301
D	UND1302

---

site_id	AE1
Number of Residues	2
Details	binding site for residue UND D 1304

Chain	Residue
C	TYR953
D	PHE864

---

site_id	AE2
Number of Residues	11
Details	binding site for residue T14 D 1305

Chain	Residue
D	VAL839
D	SER840
D	LEU843
D	TYR995
D	PHE729
D	TYR736
D	LEU769
D	ASN790
D	ASP793
D	ARG832
D	ILE836

---

site_id	AE3
Number of Residues	1
Details	binding site for residue NA D 1307

Chain	Residue
D	THR957

---

site_id	AE4
Number of Residues	16
Details	binding site for residue Y01 B 1301

Chain	Residue
B	LEU669
B	LYS671
B	GLN672
B	TYR674
B	GLY675
B	ILE687
B	PRO725
B	PHE726
B	PHE729
B	VAL733
B	ILE737
B	SER840
B	LEU843
B	ARG988
B	VAL992
B	9PE1303

---

site_id	AE5
Number of Residues	16
Details	binding site for residue Y01 C 1301

Chain	Residue
C	LEU669
C	LYS671
C	GLN672
C	TYR674
C	GLY675
C	ILE687
C	PRO725
C	PHE726
C	PHE729
C	VAL733
C	ILE737
C	SER840
C	LEU843
C	ARG988
C	VAL992
C	9PE1303

---

site_id	AE6
Number of Residues	16
Details	binding site for residue Y01 D 1301

Chain	Residue
D	LEU669
D	LYS671
D	GLN672
D	TYR674
D	GLY675
D	ILE687
D	PRO725
D	PHE726
D	PHE729
D	VAL733
D	ILE737
D	SER840
D	LEU843
D	ARG988
D	VAL992
D	9PE1303

---