6O72
Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0030001 | biological_process | metal ion transport |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0099604 | molecular_function | ligand-gated calcium channel activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0030001 | biological_process | metal ion transport |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0099604 | molecular_function | ligand-gated calcium channel activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0019722 | biological_process | calcium-mediated signaling |
| C | 0030001 | biological_process | metal ion transport |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0098655 | biological_process | monoatomic cation transmembrane transport |
| C | 0099604 | molecular_function | ligand-gated calcium channel activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0019722 | biological_process | calcium-mediated signaling |
| D | 0030001 | biological_process | metal ion transport |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0098655 | biological_process | monoatomic cation transmembrane transport |
| D | 0099604 | molecular_function | ligand-gated calcium channel activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue Y01 A 1301 |
| Chain | Residue |
| A | TRP673 |
| A | 9PE1303 |
| A | ILE687 |
| A | PHE729 |
| A | VAL733 |
| A | ILE737 |
| A | SER840 |
| A | LEU843 |
| A | ARG988 |
| A | VAL992 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue UND A 1302 |
| Chain | Residue |
| A | PHE691 |
| A | 9PE1303 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 9PE A 1303 |
| Chain | Residue |
| A | ILE737 |
| A | PHE837 |
| A | SER840 |
| A | ARG841 |
| A | LEU843 |
| A | Y011301 |
| A | UND1302 |
| D | PHE862 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue UND A 1304 |
| Chain | Residue |
| A | PHE864 |
| D | TYR953 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue T14 A 1305 |
| Chain | Residue |
| A | PHE729 |
| A | TYR736 |
| A | LEU769 |
| A | ASN790 |
| A | ASP793 |
| A | ARG832 |
| A | ILE836 |
| A | VAL839 |
| A | SER840 |
| A | LEU843 |
| A | TYR995 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue NA A 1307 |
| Chain | Residue |
| A | THR957 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue UND A 1308 |
| Chain | Residue |
| B | PHE864 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue UND B 1302 |
| Chain | Residue |
| B | PHE691 |
| B | 9PE1303 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue 9PE B 1303 |
| Chain | Residue |
| A | PHE862 |
| B | ILE737 |
| B | PHE837 |
| B | SER840 |
| B | ARG841 |
| B | LEU843 |
| B | Y011301 |
| B | UND1302 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue T14 B 1304 |
| Chain | Residue |
| B | PHE729 |
| B | TYR736 |
| B | LEU769 |
| B | ASN790 |
| B | ASP793 |
| B | ARG832 |
| B | ILE836 |
| B | VAL839 |
| B | SER840 |
| B | LEU843 |
| B | TYR995 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue NA B 1306 |
| Chain | Residue |
| B | THR957 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue UND C 1302 |
| Chain | Residue |
| C | PHE691 |
| C | 9PE1303 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue 9PE C 1303 |
| Chain | Residue |
| B | PHE862 |
| C | ILE737 |
| C | PHE837 |
| C | SER840 |
| C | ARG841 |
| C | LEU843 |
| C | Y011301 |
| C | UND1302 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue UND C 1304 |
| Chain | Residue |
| C | PHE864 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue T14 C 1305 |
| Chain | Residue |
| C | PHE729 |
| C | TYR736 |
| C | LEU769 |
| C | ASN790 |
| C | ASP793 |
| C | ARG832 |
| C | ILE836 |
| C | VAL839 |
| C | SER840 |
| C | LEU843 |
| C | TYR995 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue NA C 1307 |
| Chain | Residue |
| C | THR957 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue UND D 1302 |
| Chain | Residue |
| D | PHE691 |
| D | 9PE1303 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue 9PE D 1303 |
| Chain | Residue |
| C | PHE862 |
| D | ILE737 |
| D | PHE837 |
| D | SER840 |
| D | ARG841 |
| D | LEU843 |
| D | Y011301 |
| D | UND1302 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue UND D 1304 |
| Chain | Residue |
| C | TYR953 |
| D | PHE864 |
| site_id | AE2 |
| Number of Residues | 11 |
| Details | binding site for residue T14 D 1305 |
| Chain | Residue |
| D | VAL839 |
| D | SER840 |
| D | LEU843 |
| D | TYR995 |
| D | PHE729 |
| D | TYR736 |
| D | LEU769 |
| D | ASN790 |
| D | ASP793 |
| D | ARG832 |
| D | ILE836 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue NA D 1307 |
| Chain | Residue |
| D | THR957 |
| site_id | AE4 |
| Number of Residues | 16 |
| Details | binding site for residue Y01 B 1301 |
| Chain | Residue |
| B | LEU669 |
| B | LYS671 |
| B | GLN672 |
| B | TYR674 |
| B | GLY675 |
| B | ILE687 |
| B | PRO725 |
| B | PHE726 |
| B | PHE729 |
| B | VAL733 |
| B | ILE737 |
| B | SER840 |
| B | LEU843 |
| B | ARG988 |
| B | VAL992 |
| B | 9PE1303 |
| site_id | AE5 |
| Number of Residues | 16 |
| Details | binding site for residue Y01 C 1301 |
| Chain | Residue |
| C | LEU669 |
| C | LYS671 |
| C | GLN672 |
| C | TYR674 |
| C | GLY675 |
| C | ILE687 |
| C | PRO725 |
| C | PHE726 |
| C | PHE729 |
| C | VAL733 |
| C | ILE737 |
| C | SER840 |
| C | LEU843 |
| C | ARG988 |
| C | VAL992 |
| C | 9PE1303 |
| site_id | AE6 |
| Number of Residues | 16 |
| Details | binding site for residue Y01 D 1301 |
| Chain | Residue |
| D | LEU669 |
| D | LYS671 |
| D | GLN672 |
| D | TYR674 |
| D | GLY675 |
| D | ILE687 |
| D | PRO725 |
| D | PHE726 |
| D | PHE729 |
| D | VAL733 |
| D | ILE737 |
| D | SER840 |
| D | LEU843 |
| D | ARG988 |
| D | VAL992 |
| D | 9PE1303 |
