6O6Q
Crystal structure of Cka1p, a casein kinase 2 alpha ortholog from Candida albicans
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| A | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007535 | biological_process | donor selection |
| A | 0032040 | cellular_component | small-subunit processome |
| A | 0032545 | cellular_component | CURI complex |
| A | 0034456 | cellular_component | UTP-C complex |
| A | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005956 | cellular_component | protein kinase CK2 complex |
| B | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| B | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006974 | biological_process | DNA damage response |
| B | 0007535 | biological_process | donor selection |
| B | 0032040 | cellular_component | small-subunit processome |
| B | 0032545 | cellular_component | CURI complex |
| B | 0034456 | cellular_component | UTP-C complex |
| B | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue AMP A 401 |
| Chain | Residue |
| A | LEU49 |
| A | ILE178 |
| A | ASP179 |
| A | HOH589 |
| A | ARG51 |
| A | GLY52 |
| A | VAL57 |
| A | ILE99 |
| A | GLU118 |
| A | ILE120 |
| A | HIS164 |
| A | MET167 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | SER297 |
| A | GLN298 |
| B | ARG306 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS81 |
| A | ARG84 |
| A | ARG159 |
| A | ASN193 |
| A | HOH517 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | PRO24 |
| A | GLN25 |
| A | SER26 |
| B | HOH538 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | TYR16 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 406 |
| Chain | Residue |
| A | ARG66 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 407 |
| Chain | Residue |
| A | ARG282 |
| A | GLN283 |
| B | LYS319 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 408 |
| Chain | Residue |
| A | ARG195 |
| A | SER198 |
| A | ARG199 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 409 |
| Chain | Residue |
| A | ARG309 |
| A | TYR310 |
| A | ASP311 |
| A | GLU314 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue AMP B 401 |
| Chain | Residue |
| B | LEU49 |
| B | VAL57 |
| B | VAL70 |
| B | GLU118 |
| B | HIS119 |
| B | ILE120 |
| B | HIS164 |
| B | MET167 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | PRO24 |
| B | GLN25 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | ARG138 |
| B | SER297 |
| B | GLU299 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | ASN280 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | VAL296 |
| B | GLN298 |
| B | HOH517 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFlGidlekrek..........VVIK |
| Chain | Residue | Details |
| A | LEU49-LYS72 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE156-ILE168 |
