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6O3Z

Crystal structure of RORgt with 3-cyano-N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)benzamide (compound 1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue LKY A 601
ChainResidue
AGLN286
AVAL376
APHE377
APHE378
APHE388
ALEU396
ASER404
AHIS479
ALEU287
ATRP317
ACYS320
AHIS323
ALEU324
AMET365
AARG367
AALA368

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 602
ChainResidue
AHIS272
ASER276
AARG294
ASER339
AHOH721

site_idAC3
Number of Residues6
Detailsbinding site for residue EDO A 603
ChainResidue
ACYS366
ALEU407
ASER408
APHE412
AEDO606
AHOH708

site_idAC4
Number of Residues6
Detailsbinding site for residue EDO A 604
ChainResidue
ACYS455
ALYS456
AGLN495
AALA496
APHE498
ALYS503

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO A 605
ChainResidue
AARG282
AGLU283
ACYS285
ATYR330
AHOH735

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO A 606
ChainResidue
AARG296
AALA371
AEDO603
AHOH708

site_idAC7
Number of Residues4
Detailsbinding site for residue EDO A 607
ChainResidue
AGLN329
ATYR330
AGLU333
AHOH735

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PDB entries from 2024-11-06

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