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6O1G

Full length human plasma kallikrein with inhibitor

Replaces:  6ESO
Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU430-CYS435

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLV
ChainResidueDetails
AASP572-VAL583

site_idPS00495
Number of Residues84
DetailsAPPLE Apple domain. CltqLyenafFrggDVasmytpnaqyCqmrCTfhprClLFsFlpassindmekrfgCfLKdSvtgtlpkvhrtgav.SGhSLkqC
ChainResidueDetails
ACYS21-CYS104
ACYS111-CYS194
ACYS201-CYS284
ACYS292-CYS375

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS434
AASP483
ASER578

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:3521732
ChainResidueDetails
AASN127

site_idSWS_FT_FI3
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3521732
ChainResidueDetails
AASN308
AASN396
AASN494

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3521732
ChainResidueDetails
AASN453

222624

PDB entries from 2024-07-17

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