6NRH
Crystal Structure of human PARP-1 ART domain bound inhibitor UTT63
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue KYP A 1101 |
| Chain | Residue |
| A | HIS862 |
| A | DMS1107 |
| A | HOH1215 |
| A | HOH1264 |
| A | HOH1348 |
| A | HOH1356 |
| A | GLY863 |
| A | ASN868 |
| A | GLY888 |
| A | TYR889 |
| A | TYR896 |
| A | PHE897 |
| A | SER904 |
| A | TYR907 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1102 |
| Chain | Residue |
| A | LYS766 |
| A | LYS903 |
| A | LEU984 |
| A | LEU985 |
| A | TYR986 |
| A | HOH1233 |
| A | HOH1268 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1103 |
| Chain | Residue |
| A | ARG806 |
| A | LYS953 |
| A | ASN980 |
| A | ASP981 |
| A | THR982 |
| A | HOH1363 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1104 |
| Chain | Residue |
| A | LYS849 |
| A | ASN998 |
| A | LYS1000 |
| A | HOH1222 |
| A | HOH1235 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1105 |
| Chain | Residue |
| A | ARG858 |
| A | MET929 |
| A | LYS949 |
| A | HOH1202 |
| A | HOH1261 |
| A | HOH1366 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1106 |
| Chain | Residue |
| A | ASN906 |
| A | TYR907 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 1107 |
| Chain | Residue |
| A | HIS862 |
| A | ARG878 |
| A | TYR889 |
| A | GLY894 |
| A | ILE895 |
| A | TYR896 |
| A | KYP1101 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue DMS A 1108 |
| Chain | Residue |
| A | LYS798 |
| A | THR799 |
| A | GLU883 |
| A | ALA884 |
| A | PRO885 |
| A | HOH1239 |
| A | HOH1255 |
| A | HOH1270 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7852410","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9315851","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UGN5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
