Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NPL

Cryo-EM structure of NKCC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006811	biological_process	monoatomic ion transport
A	0015377	molecular_function	chloride:monoatomic cation symporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
B	0006811	biological_process	monoatomic ion transport
B	0015377	molecular_function	chloride:monoatomic cation symporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue K A 1201

Chain	Residue
A	ASN220
A	ILE221
A	TYR305
A	PRO417
A	THR420

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 1202

Chain	Residue
A	GLY223
A	VAL224
A	MET225

site_id	AC3
Number of Residues	6
Details	binding site for residue CL A 1203

Chain	Residue
A	GLY421
A	ILE422
A	LEU423
A	PHE607
A	TYR611
A	PHE294

site_id	AC4
Number of Residues	7
Details	binding site for residue POV A 1204

Chain	Residue
A	ALA609
A	LEU623
A	ASN625
A	ASN664
A	POV1206
B	SER669
B	TYR673

site_id	AC5
Number of Residues	3
Details	binding site for residue POV A 1205

Chain	Residue
A	ILE654
A	ASN656
B	TRP657

site_id	AC6
Number of Residues	3
Details	binding site for residue POV A 1206

Chain	Residue
A	TRP639
A	POV1204
B	SER669

site_id	AC7
Number of Residues	5
Details	binding site for residue K B 1201

Chain	Residue
B	ASN220
B	ILE221
B	TYR305
B	PRO417
B	THR420

site_id	AC8
Number of Residues	5
Details	binding site for residue CL B 1202

Chain	Residue
B	GLY223
B	VAL224
B	MET225
B	TYR305
B	ALA418

site_id	AC9
Number of Residues	6
Details	binding site for residue CL B 1203

Chain	Residue
B	PHE294
B	GLY421
B	ILE422
B	LEU423
B	PHE607
B	TYR611

site_id	AD1
Number of Residues	4
Details	binding site for residue POV B 1204

Chain	Residue
A	TRP657
B	ILE654
B	ILE655
B	TRP657

site_id	AD2
Number of Residues	8
Details	binding site for residue POV B 1205

Chain	Residue
A	SER669
A	TYR673
A	TYR676
B	LEU623
B	ASN625
B	TRP639
B	ASN664
B	POV1207

site_id	AD3
Number of Residues	12
Details	binding site for residue POV B 1206

Chain	Residue
A	PHE616
A	CYS649
A	TYR671
A	TYR676
B	HIS620
B	CYS649
B	PHE653
B	ASN664
B	VAL667
B	TYR671
B	SER675
B	TYR676

site_id	AD4
Number of Residues	4
Details	binding site for residue POV B 1207

Chain	Residue
A	SER669
B	MET638
B	TRP639
B	POV1205

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Transmembrane: {"description":"Discontinuously helical; Name=1","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	210
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	146
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	38
Details	Transmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	26
Details	Region: {"description":"Scissor helix","evidences":[{"source":"PubMed","id":"31367042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P55011","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PDB","id":"6NPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"6NPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P55013","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)