6NJT

Mouse endonuclease G mutant - H97A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 301

Chain	Residue
A	ASN128
A	HOH407
A	HOH429
A	HOH436
A	HOH522
A	HOH524

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 302

Chain	Residue
A	HOH595
A	ARG72
A	GLU73
A	ASN85

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 303

Chain	Residue
A	ARG95
B	CYS69

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CL A 304

Chain	Residue
A	ARG160
A	LYS170
B	ARG144
B	ARG160
B	LYS170

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 305

Chain	Residue
A	ALA102
A	HOH563
B	GLN129

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CL A 306

Chain	Residue
A	SER225

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL A 308

Chain	Residue
A	GLU19
A	LEU20

---

site_id	AC8
Number of Residues	5
Details	binding site for residue IPA A 309

Chain	Residue
A	GLN172
A	ILE174
A	GLY175
A	HOH441
A	HOH450

---

site_id	AC9
Number of Residues	2
Details	binding site for residue IPA A 310

Chain	Residue
A	THR183
A	ASN207

---

site_id	AD1
Number of Residues	3
Details	binding site for residue IPA A 311

Chain	Residue
A	ASN134
A	THR161
A	GLU212

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MG B 301

Chain	Residue
B	ASN128
B	HOH422
B	HOH435
B	HOH437
B	HOH550
B	HOH561

---

site_id	AD3
Number of Residues	3
Details	binding site for residue CL B 302

Chain	Residue
B	ARG72
B	GLU73
B	ASN85

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL B 303

Chain	Residue
A	GLN129
B	ALA102
B	HOH532
B	HOH601

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CL B 304

Chain	Residue
A	CYS69
B	ARG95

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL B 305

Chain	Residue
B	TYR171
B	GLN172
B	VAL181

---

site_id	AD7
Number of Residues	4
Details	binding site for residue IPA B 306

Chain	Residue
B	SER91
B	ILE174
B	GLY175
B	HOH453

---

site_id	AD8
Number of Residues	6
Details	binding site for residue IPA B 307

Chain	Residue
B	ARG66
B	ARG72
B	ARG109
B	ASP112
B	TYR116
B	HOH407

---

site_id	AD9
Number of Residues	2
Details	binding site for residue IPA B 308

Chain	Residue
B	SER225
B	HOH572

---

site_id	AE1
Number of Residues	2
Details	binding site for residue IPA B 309

Chain	Residue
B	ASP75
B	VAL77

---

site_id	AE2
Number of Residues	7
Details	binding site for residue IPA B 310

Chain	Residue
A	ILE190
A	PHE234
A	ILE238
B	TYR23
B	GLY24
B	LEU25
B	PRO26

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10047","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32095813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32192768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32095813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32192768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LYF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NJT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Essential for catalytic activity","evidences":[{"source":"PubMed","id":"32192768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q14249","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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