6NJH

Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 701

Chain	Residue
A	HIS330
A	HIS366
A	ASP367
A	ASP484
A	HOH805
A	HOH850

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 702

Chain	Residue
A	HOH869
A	HOH875
A	HOH924
A	ASP367
A	HOH805
A	HOH807

---

site_id	AC3
Number of Residues	11
Details	binding site for residue KRD A 703

Chain	Residue
A	HIS326
A	ASN487
A	THR499
A	PHE506
A	GLN535
A	PHE538
A	PHE599
A	HOH832
A	HOH837
A	HOH862
A	HOH871

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 704

Chain	Residue
A	GLU384
A	HOH937
C	HIS318
C	HOH953

---

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN B 701

Chain	Residue
B	HIS330
B	HIS366
B	ASP367
B	ASP484
B	HOH816
B	HOH876

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG B 702

Chain	Residue
B	ASP367
B	HOH816
B	HOH840
B	HOH865
B	HOH880
B	HOH910

---

site_id	AC7
Number of Residues	15
Details	binding site for residue KRD B 703

Chain	Residue
B	HIS326
B	ASN487
B	TRP498
B	THR499
B	ILE502
B	PHE506
B	MET523
B	GLN535
B	PHE538
B	PHE599
B	ILE600
B	HOH839
B	HOH850
B	HOH856
B	HOH885

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN C 700

Chain	Residue
C	HIS330
C	HIS366
C	ASP367
C	ASP484
C	HOH816
C	HOH910

---

site_id	AC9
Number of Residues	6
Details	binding site for residue MG C 701

Chain	Residue
C	ASP367
C	HOH816
C	HOH853
C	HOH873
C	HOH915
C	HOH940

---

site_id	AD1
Number of Residues	12
Details	binding site for residue KRD C 702

Chain	Residue
C	HIS326
C	ASN487
C	THR499
C	ILE502
C	PHE506
C	MET523
C	GLN535
C	PHE538
C	PHE599
C	HOH826
C	HOH877
C	HOH894

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MG D 701

Chain	Residue
B	HIS318
D	GLU384
D	HOH904
D	HOH913

---

site_id	AD3
Number of Residues	6
Details	binding site for residue ZN D 702

Chain	Residue
D	HIS330
D	HIS366
D	ASP367
D	ASP484
D	HOH806
D	HOH862

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MG D 703

Chain	Residue
D	ASP367
D	HOH806
D	HOH816
D	HOH818
D	HOH877
D	HOH898

---

site_id	AD5
Number of Residues	13
Details	binding site for residue KRD D 704

Chain	Residue
D	MET523
D	GLN535
D	PHE538
D	PHE599
D	HOH802
D	HOH857
D	HOH864
D	HOH871
D	HIS326
D	SER374
D	ASN487
D	TRP498
D	THR499

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS366-PHE377

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---