6NIL

cryoEM structure of the truncated HIV-1 Vif/CBFbeta/A3F complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
B	0003713	molecular_function	transcription coactivator activity
B	0005634	cellular_component	nucleus
C	0019058	biological_process	viral life cycle
D	0003824	molecular_function	catalytic activity
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
E	0003713	molecular_function	transcription coactivator activity
E	0005634	cellular_component	nucleus
F	0019058	biological_process	viral life cycle
G	0003824	molecular_function	catalytic activity
G	0008270	molecular_function	zinc ion binding
G	0016787	molecular_function	hydrolase activity
H	0003713	molecular_function	transcription coactivator activity
H	0005634	cellular_component	nucleus
I	0019058	biological_process	viral life cycle
J	0003824	molecular_function	catalytic activity
J	0008270	molecular_function	zinc ion binding
J	0016787	molecular_function	hydrolase activity
K	0003713	molecular_function	transcription coactivator activity
K	0005634	cellular_component	nucleus
L	0019058	biological_process	viral life cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	HIS249
A	GLU251
A	CYS280
A	CYS283

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	HIS249
D	GLU251
D	CYS280
D	CYS283

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN G 501

Chain	Residue
G	GLU251
G	CYS280
G	CYS283
G	HIS249

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN J 501

Chain	Residue
J	HIS249
J	GLU251
J	CYS280
J	CYS283

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAErcFLswfcddilspntnyevtwytsws..........PCpe......CageV

Chain	Residue	Details
A	HIS249-VAL287

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24402281, ECO:0000269|PubMed:37640699, ECO:0007744|PDB:4N9F, ECO:0007744|PDB:8FVI

Chain	Residue	Details
C	HIS108
F	HIS108
I	HIS108
L	HIS108

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081

Chain	Residue	Details
C	THR96
J	HIS249
J	CYS280
J	CYS283
F	THR96
I	THR96
L	THR96
D	CYS280
D	CYS283
G	HIS249
G	CYS280
G	CYS283

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081

Chain	Residue	Details
C	SER165
D	LYS352
D	ASP355
D	ASP358
G	LYS234
G	LYS334
G	LYS352
G	ASP355
G	ASP358
J	LYS234
F	SER165
J	LYS334
J	LYS352
J	ASP355
J	ASP358
I	SER165
L	SER165
A	ASP355
A	ASP358
D	LYS234
D	LYS334

---