6NIL
cryoEM structure of the truncated HIV-1 Vif/CBFbeta/A3F complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0005634 | cellular_component | nucleus |
| C | 0019058 | biological_process | viral life cycle |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016787 | molecular_function | hydrolase activity |
| E | 0003713 | molecular_function | transcription coactivator activity |
| E | 0005634 | cellular_component | nucleus |
| F | 0019058 | biological_process | viral life cycle |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0016787 | molecular_function | hydrolase activity |
| H | 0003713 | molecular_function | transcription coactivator activity |
| H | 0005634 | cellular_component | nucleus |
| I | 0019058 | biological_process | viral life cycle |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0008270 | molecular_function | zinc ion binding |
| J | 0016787 | molecular_function | hydrolase activity |
| K | 0003713 | molecular_function | transcription coactivator activity |
| K | 0005634 | cellular_component | nucleus |
| L | 0019058 | biological_process | viral life cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | HIS249 |
| A | GLU251 |
| A | CYS280 |
| A | CYS283 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 501 |
| Chain | Residue |
| D | HIS249 |
| D | GLU251 |
| D | CYS280 |
| D | CYS283 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 501 |
| Chain | Residue |
| G | GLU251 |
| G | CYS280 |
| G | CYS283 |
| G | HIS249 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN J 501 |
| Chain | Residue |
| J | HIS249 |
| J | GLU251 |
| J | CYS280 |
| J | CYS283 |
Functional Information from PROSITE/UniProt
| site_id | PS00903 |
| Number of Residues | 39 |
| Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAErcFLswfcddilspntnyevtwytsws..........PCpe......CageV |
| Chain | Residue | Details |
| A | HIS249-VAL287 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31792451","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NIL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27139641","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31792451","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NIL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Region: {"description":"Interaction with host APOBEC3F; F1-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Region: {"description":"Interaction with host APOBEC3G; G-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 72 |
| Details | Region: {"description":"Interaction with host APOBEC3F and APOBEC3G; FG-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Region: {"description":"Interaction with host APOBEC3F; F2-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 156 |
| Details | Region: {"description":"RNA-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Region: {"description":"Membrane association","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24402281","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37640699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FVI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
