6NFL

Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G complexed with 2-HP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue L60 A 401

Chain	Residue
A	ARG210
A	ARG211
A	GLN213
A	THR214
A	ASN240
A	HIS253
A	TRP281
A	PHE285
A	HOH555

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site_id	AC2
Number of Residues	4
Details	binding site for residue 71O A 402

Chain	Residue
A	GLU219
A	ARG306
A	GLU340
A	TYR343

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site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 403

Chain	Residue
A	SER334
A	ILE335
A	SER370
A	ARG374

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site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 404

Chain	Residue
A	ARG212
A	ASN240
A	SER250
A	GLY251
A	GLU342

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site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 405

Chain	Residue
A	PHE237
A	GLU241
A	THR337
A	HOH502
A	HOH569
A	HOH585

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site_id	AC6
Number of Residues	1
Details	binding site for residue EDO A 406

Chain	Residue
A	LEU379

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Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	41
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElrFLdlvpslqldpaqiyrvtwfisws..........PCfswg....CageV

Chain	Residue	Details
A	HIS253-VAL293

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255

Chain	Residue	Details
A	PRO263

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LEU261
A	GLU292
A	LEU297

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