6ND3
wild-type choline TMA lyase in complex with betaine aldehyde
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005829 | cellular_component | cytosol |
A | 0016829 | molecular_function | lyase activity |
A | 0016840 | molecular_function | carbon-nitrogen lyase activity |
A | 0033265 | molecular_function | choline binding |
A | 0042426 | biological_process | choline catabolic process |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0005829 | cellular_component | cytosol |
B | 0016829 | molecular_function | lyase activity |
B | 0016840 | molecular_function | carbon-nitrogen lyase activity |
B | 0033265 | molecular_function | choline binding |
B | 0042426 | biological_process | choline catabolic process |
B | 0042803 | molecular_function | protein homodimerization activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0005829 | cellular_component | cytosol |
C | 0016829 | molecular_function | lyase activity |
C | 0016840 | molecular_function | carbon-nitrogen lyase activity |
C | 0033265 | molecular_function | choline binding |
C | 0042426 | biological_process | choline catabolic process |
C | 0042803 | molecular_function | protein homodimerization activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0005829 | cellular_component | cytosol |
D | 0016829 | molecular_function | lyase activity |
D | 0016840 | molecular_function | carbon-nitrogen lyase activity |
D | 0033265 | molecular_function | choline binding |
D | 0042426 | biological_process | choline catabolic process |
D | 0042803 | molecular_function | protein homodimerization activity |
E | 0003824 | molecular_function | catalytic activity |
E | 0005829 | cellular_component | cytosol |
E | 0016829 | molecular_function | lyase activity |
E | 0016840 | molecular_function | carbon-nitrogen lyase activity |
E | 0033265 | molecular_function | choline binding |
E | 0042426 | biological_process | choline catabolic process |
E | 0042803 | molecular_function | protein homodimerization activity |
F | 0003824 | molecular_function | catalytic activity |
F | 0005829 | cellular_component | cytosol |
F | 0016829 | molecular_function | lyase activity |
F | 0016840 | molecular_function | carbon-nitrogen lyase activity |
F | 0033265 | molecular_function | choline binding |
F | 0042426 | biological_process | choline catabolic process |
F | 0042803 | molecular_function | protein homodimerization activity |
G | 0003824 | molecular_function | catalytic activity |
G | 0005829 | cellular_component | cytosol |
G | 0016829 | molecular_function | lyase activity |
G | 0016840 | molecular_function | carbon-nitrogen lyase activity |
G | 0033265 | molecular_function | choline binding |
G | 0042426 | biological_process | choline catabolic process |
G | 0042803 | molecular_function | protein homodimerization activity |
H | 0003824 | molecular_function | catalytic activity |
H | 0005829 | cellular_component | cytosol |
H | 0016829 | molecular_function | lyase activity |
H | 0016840 | molecular_function | carbon-nitrogen lyase activity |
H | 0033265 | molecular_function | choline binding |
H | 0042426 | biological_process | choline catabolic process |
H | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue BTL A 901 |
Chain | Residue |
A | TYR208 |
A | ASP216 |
A | PHE395 |
A | CYS489 |
A | GLU491 |
A | TYR506 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for Di-peptide BTL B 901 and CYS B 489 |
Chain | Residue |
B | MET487 |
B | GLY488 |
B | VAL490 |
B | GLU491 |
B | TYR506 |
B | GLY821 |
B | TYR208 |
B | ASP216 |
B | PHE395 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for Di-peptide BTL C 901 and CYS C 489 |
Chain | Residue |
C | TYR208 |
C | ASP216 |
C | PHE395 |
C | MET487 |
C | GLY488 |
C | VAL490 |
C | GLU491 |
C | TYR506 |
C | LEU698 |
C | GLY821 |
C | HOH1056 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for Di-peptide BTL D 901 and CYS D 489 |
Chain | Residue |
D | TYR208 |
D | ASP216 |
D | PHE395 |
D | MET487 |
D | GLY488 |
D | VAL490 |
D | GLU491 |
D | TYR506 |
D | GLY821 |
D | HOH1048 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for Di-peptide BTL E 901 and CYS E 489 |
Chain | Residue |
E | TYR208 |
E | ASP216 |
E | PHE395 |
E | MET487 |
E | GLY488 |
E | VAL490 |
E | GLU491 |
E | TYR506 |
E | LEU698 |
E | GLY821 |
E | HOH1056 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for Di-peptide BTL F 901 and CYS F 489 |
Chain | Residue |
F | TYR208 |
F | ASP216 |
F | ASN397 |
F | MET487 |
F | GLY488 |
F | VAL490 |
F | GLU491 |
F | TYR506 |
F | GLY821 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for Di-peptide BTL G 901 and CYS G 489 |
Chain | Residue |
G | TYR208 |
G | ASP216 |
G | PHE395 |
G | MET487 |
G | GLY488 |
G | VAL490 |
G | GLU491 |
G | TYR506 |
G | GLY821 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for Di-peptide BTL H 901 and CYS H 489 |
Chain | Residue |
H | TYR208 |
H | ASP216 |
H | PHE395 |
H | MET487 |
H | GLY488 |
H | VAL490 |
H | GLU491 |
H | TYR506 |
H | LEU698 |
H | GLY821 |
H | HOH1014 |
Functional Information from PROSITE/UniProt
site_id | PS00850 |
Number of Residues | 9 |
Details | GLY_RADICAL_1 Glycine radical domain signature. VvRVAGYSA |
Chain | Residue | Details |
A | VAL816-ALA824 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Cysteine radical intermediate => ECO:0000255|HAMAP-Rule:MF_02058, ECO:0000305|PubMed:23151509, ECO:0000305|PubMed:24854437 |
Chain | Residue | Details |
A | CYS489 | |
B | CYS489 | |
C | CYS489 | |
D | CYS489 | |
E | CYS489 | |
F | CYS489 | |
G | CYS489 | |
H | CYS489 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_02058, ECO:0000305|PubMed:24854437 |
Chain | Residue | Details |
A | GLU491 | |
B | GLU491 | |
C | GLU491 | |
D | GLU491 | |
E | GLU491 | |
F | GLU491 | |
G | GLU491 | |
H | GLU491 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | MOD_RES: Glycine radical => ECO:0000255|HAMAP-Rule:MF_02058, ECO:0000305|PubMed:23151509, ECO:0000305|PubMed:24854437 |
Chain | Residue | Details |
A | GLY821 | |
B | GLY821 | |
C | GLY821 | |
D | GLY821 | |
E | GLY821 | |
F | GLY821 | |
G | GLY821 | |
H | GLY821 |