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6NBW

Ternary Complex of Beta/Gamma-Actin with Profilin and AnCoA-NAA80

Functional Information from GO Data
ChainGOidnamespacecontents
A0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
A0000776cellular_componentkinetochore
A0000785cellular_componentchromatin
A0000786cellular_componentnucleosome
A0001738biological_processmorphogenesis of a polarized epithelium
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0005911cellular_componentcell-cell junction
A0005912cellular_componentadherens junction
A0005925cellular_componentfocal adhesion
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0007010biological_processcytoskeleton organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007409biological_processaxonogenesis
A0008284biological_processpositive regulation of cell population proliferation
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016514cellular_componentSWI/SNF complex
A0016586cellular_componentRSC-type complex
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0019894molecular_functionkinesin binding
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0022898biological_processregulation of transmembrane transporter activity
A0030027cellular_componentlamellipodium
A0030071biological_processregulation of mitotic metaphase/anaphase transition
A0030424cellular_componentaxon
A0030863cellular_componentcortical cytoskeleton
A0030957molecular_functionTat protein binding
A0031492molecular_functionnucleosomal DNA binding
A0031982cellular_componentvesicle
A0032091biological_processnegative regulation of protein binding
A0032991cellular_componentprotein-containing complex
A0034333biological_processadherens junction assembly
A0035060cellular_componentbrahma complex
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0035633biological_processmaintenance of blood-brain barrier
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043296cellular_componentapical junction complex
A0044305cellular_componentcalyx of Held
A0045176biological_processapical protein localization
A0045202cellular_componentsynapse
A0045582biological_processpositive regulation of T cell differentiation
A0045596biological_processnegative regulation of cell differentiation
A0045597biological_processpositive regulation of cell differentiation
A0045663biological_processpositive regulation of myoblast differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0048156molecular_functiontau protein binding
A0048870biological_processcell motility
A0050998molecular_functionnitric-oxide synthase binding
A0051621biological_processregulation of norepinephrine uptake
A0051623biological_processpositive regulation of norepinephrine uptake
A0051726biological_processregulation of cell cycle
A0070062cellular_componentextracellular exosome
A0070160cellular_componenttight junction
A0070316biological_processregulation of G0 to G1 transition
A0070527biological_processplatelet aggregation
A0071564cellular_componentnpBAF complex
A0071565cellular_componentnBAF complex
A0071896biological_processprotein localization to adherens junction
A0072562cellular_componentblood microparticle
A0072749biological_processcellular response to cytochalasin B
A0097433cellular_componentdense body
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098871cellular_componentpostsynaptic actin cytoskeleton
A0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A0140092cellular_componentbBAF complex
A0140288cellular_componentGBAF complex
A0150111biological_processregulation of transepithelial transport
A1900242biological_processregulation of synaptic vesicle endocytosis
A1902459biological_processpositive regulation of stem cell population maintenance
A1903076biological_processregulation of protein localization to plasma membrane
A1905168biological_processpositive regulation of double-strand break repair via homologous recombination
A1990904cellular_componentribonucleoprotein complex
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
A2000779biological_processregulation of double-strand break repair
A2000781biological_processpositive regulation of double-strand break repair
A2000819biological_processregulation of nucleotide-excision repair
N0008080molecular_functionN-acetyltransferase activity
N0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
P0000774molecular_functionadenyl-nucleotide exchange factor activity
P0001784molecular_functionphosphotyrosine residue binding
P0001843biological_processneural tube closure
P0003723molecular_functionRNA binding
P0003779molecular_functionactin binding
P0003785molecular_functionactin monomer binding
P0005515molecular_functionprotein binding
P0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0005925cellular_componentfocal adhesion
P0005938cellular_componentcell cortex
P0006357biological_processregulation of transcription by RNA polymerase II
P0010634biological_processpositive regulation of epithelial cell migration
P0016020cellular_componentmembrane
P0030036biological_processactin cytoskeleton organization
P0030833biological_processregulation of actin filament polymerization
P0030837biological_processnegative regulation of actin filament polymerization
P0030838biological_processpositive regulation of actin filament polymerization
P0031267molecular_functionsmall GTPase binding
P0032232biological_processnegative regulation of actin filament bundle assembly
P0032233biological_processpositive regulation of actin filament bundle assembly
P0032781biological_processpositive regulation of ATP-dependent activity
P0044087biological_processregulation of cellular component biogenesis
P0045296molecular_functioncadherin binding
P0050804biological_processmodulation of chemical synaptic transmission
P0050821biological_processprotein stabilization
P0051497biological_processnegative regulation of stress fiber assembly
P0060074biological_processsynapse maturation
P0070062cellular_componentextracellular exosome
P0070064molecular_functionproline-rich region binding
P0072562cellular_componentblood microparticle
P0098885biological_processmodification of postsynaptic actin cytoskeleton
P0098978cellular_componentglutamatergic synapse
P0110053biological_processregulation of actin filament organization
P1900029biological_processpositive regulation of ruffle assembly
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CA A 401
ChainResidue
AATP402
AHOH511
AHOH518
AHOH519
AHOH522
AHOH533

site_idAC2
Number of Residues26
Detailsbinding site for residue ATP A 402
ChainResidue
AMET16
ALYS18
AGLY74
AGLY156
AASP157
AGLY158
AVAL159
AGLY182
AARG210
ALYS213
AGLU214
AGLY301
AGLY302
ATHR303
AMET305
ATYR306
ALYS336
ACA401
AHOH518
AHOH533
AHOH542
AHOH549
AHOH552
AGLY13
ASER14
AGLY15

site_idAC3
Number of Residues12
Detailsbinding site for residue LAB A 403
ChainResidue
AGLY15
AMET16
AILE34
AGLN59
AARG62
ATYR69
AASP157
AARG183
ATHR186
AARG206
AGLU207
AARG210

site_idAC4
Number of Residues5
Detailsbinding site for residue GOL A 404
ChainResidue
AGLU72
AHIC73
AGLY158
AASP184
AHOH510

site_idAC5
Number of Residues3
Detailsbinding site for residue GOL A 405
ChainResidue
ASER199
APHE200
AGLU205

site_idAC6
Number of Residues28
Detailsbinding site for residue SOP N 400
ChainResidue
ALEU267
AGLY268
NHIS76
NGLN104
NTHR162
NVAL163
NVAL164
NVAL165
NARG170
NGLY171
NARG172
NGLY173
NPHE174
NGLY175
NARG176
NTHR197
NTHR198
NGLN201
NHIS203
NPHE204
NTYR205
NHIS207
NHOH509
NHOH511
NHOH521
NHOH527
NHOH530
NHOH541

site_idAC7
Number of Residues11
Detailsbinding site for residue MES N 401
ChainResidue
ASER234
AGLU237
ALYS238
ASER239
NPHE123
NARG150
NPRO155
NGLN156
NARG189
NGLY190
NPHE191

Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00414
Number of Residues9
DetailsPROFILIN Profilin signature. mAgWNaYiD
ChainResidueDetails
PMET0-ASP8

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:3342873, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712
ChainResidueDetails
PALA1
NARG112
NVAL163
NGLY171
NGLN201

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62963
ChainResidueDetails
PSER27
AMET47

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
PSER56

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
PSER84

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
PLYS104
PLYS107

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
PTYR128
AGLU270

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ROCK1 => ECO:0000269|PubMed:18573880
ChainResidueDetails
PSER137

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
PLYS53

225946

PDB entries from 2024-10-09

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