Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NAQ

Crystal structure of Neisseria meningitidis ClpP protease in Apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue K A 301

Chain	Residue
A	MET85
A	ILE88
A	PRO90
A	HOH435
A	HOH437

site_id	AC2
Number of Residues	6
Details	binding site for residue K B 301

Chain	Residue
B	HOH422
B	HOH445
B	MET85
B	ILE88
B	PRO90
B	HOH409

site_id	AC3
Number of Residues	5
Details	binding site for residue K C 301

Chain	Residue
C	MET85
C	ILE88
C	PRO90
C	HOH407
C	HOH421

site_id	AC4
Number of Residues	6
Details	binding site for residue K D 301

Chain	Residue
D	MET85
D	ILE88
D	PRO90
D	HOH411
D	HOH427
D	HOH439

site_id	AC5
Number of Residues	5
Details	binding site for residue K E 301

Chain	Residue
E	MET85
E	ILE88
E	PRO90
E	HOH404
E	HOH424

site_id	AC6
Number of Residues	6
Details	binding site for residue K F 301

Chain	Residue
F	MET85
F	ILE88
F	PRO90
F	HOH417
F	HOH420
F	HOH432

site_id	AC7
Number of Residues	5
Details	binding site for residue K G 301

Chain	Residue
G	MET85
G	ILE88
G	PRO90
G	HOH427
G	HOH443

site_id	AC8
Number of Residues	5
Details	binding site for residue K H 301

Chain	Residue
H	MET85
H	ILE88
H	PRO90
H	HOH402
H	HOH418

site_id	AC9
Number of Residues	5
Details	binding site for residue K I 301

Chain	Residue
I	MET85
I	ILE88
I	PRO90
I	HOH416
I	HOH426

site_id	AD1
Number of Residues	5
Details	binding site for residue K J 301

Chain	Residue
J	MET85
J	ILE88
J	PRO90
J	HOH410
J	HOH430

site_id	AD2
Number of Residues	5
Details	binding site for residue K K 301

Chain	Residue
K	MET85
K	ILE88
K	PRO90
K	HOH417
K	HOH429

site_id	AD3
Number of Residues	6
Details	binding site for residue K L 301

Chain	Residue
L	MET85
L	ILE88
L	PRO90
L	HOH419
L	HOH426
L	HOH437

site_id	AD4
Number of Residues	5
Details	binding site for residue K M 301

Chain	Residue
M	MET85
M	ILE88
M	PRO90
M	HOH412
M	HOH438

site_id	AD5
Number of Residues	6
Details	binding site for residue K N 301

Chain	Residue
N	MET85
N	ILE88
N	PRO90
N	HOH414
N	HOH433
N	HOH447

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TlcLGqAASMGA

Chain	Residue	Details
A	THR94-ALA105

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnsrIMIHQP

Chain	Residue	Details
A	ARG116-PRO129

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	SER102
J	SER102
K	SER102
L	SER102
M	SER102
N	SER102
B	SER102
C	SER102
D	SER102
E	SER102
F	SER102
G	SER102
H	SER102
I	SER102

site_id	SWS_FT_FI2
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	HIS127
J	HIS127
K	HIS127
L	HIS127
M	HIS127
N	HIS127
B	HIS127
C	HIS127
D	HIS127
E	HIS127
F	HIS127
G	HIS127
H	HIS127
I	HIS127

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)