6N8Q
Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 2.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005912 | cellular_component | adherens junction |
| A | 0006887 | biological_process | exocytosis |
| A | 0006893 | biological_process | Golgi to plasma membrane transport |
| A | 0008593 | biological_process | regulation of Notch signaling pathway |
| A | 0015820 | biological_process | L-leucine transport |
| A | 0030165 | molecular_function | PDZ domain binding |
| A | 0030864 | cellular_component | cortical actin cytoskeleton |
| A | 0030866 | biological_process | cortical actin cytoskeleton organization |
| A | 0032878 | biological_process | regulation of establishment or maintenance of cell polarity |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045159 | molecular_function | myosin II binding |
| A | 0045197 | biological_process | establishment or maintenance of epithelial cell apical/basal polarity |
| A | 0051294 | biological_process | establishment of spindle orientation |
| A | 0051301 | biological_process | cell division |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 1001 |
| Chain | Residue |
| A | GLN22 |
| A | GLN22 |
| A | PHE23 |
| A | PHE23 |
| A | HOH1116 |
| A | HOH1116 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1002 |
| Chain | Residue |
| A | GLU65 |
| A | TYR378 |
| A | LEU379 |
| A | VAL455 |
| A | CYS456 |
| A | LEU457 |
| A | GLU28 |
| A | HIS29 |
| A | GLY30 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLTGheDgTVRFWDA |
| Chain | Residue | Details |
| A | LEU438-ALA452 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:12725730 |
| Chain | Residue | Details |
| A | SER653 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER965 |
