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6N8P

Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 1.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0006887biological_processexocytosis
A0006893biological_processGolgi to plasma membrane transport
A0008593biological_processregulation of Notch signaling pathway
A0015820biological_processL-leucine transport
A0030165molecular_functionPDZ domain binding
A0030864cellular_componentcortical actin cytoskeleton
A0030866biological_processcortical actin cytoskeleton organization
A0032878biological_processregulation of establishment or maintenance of cell polarity
A0043231cellular_componentintracellular membrane-bounded organelle
A0045159molecular_functionmyosin II binding
A0045197biological_processestablishment or maintenance of epithelial cell apical/basal polarity
A0051294biological_processestablishment of spindle orientation
A0051301biological_processcell division
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue CL A 1001
ChainResidue
ALYS514
ALYS801
ATYR906

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLTGheDgTVRFWDA
ChainResidueDetails
ALEU438-ALA452

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12725730
ChainResidueDetails
ASER653

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER965

227344

PDB entries from 2024-11-13

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