6N8P
Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 1.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001890 | biological_process | placenta development |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005912 | cellular_component | adherens junction |
| A | 0006887 | biological_process | exocytosis |
| A | 0006893 | biological_process | Golgi to plasma membrane transport |
| A | 0008593 | biological_process | regulation of Notch signaling pathway |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0015820 | biological_process | L-leucine transport |
| A | 0016332 | biological_process | establishment or maintenance of polarity of embryonic epithelium |
| A | 0030165 | molecular_function | PDZ domain binding |
| A | 0030864 | cellular_component | cortical actin cytoskeleton |
| A | 0030866 | biological_process | cortical actin cytoskeleton organization |
| A | 0032878 | biological_process | regulation of establishment or maintenance of cell polarity |
| A | 0035264 | biological_process | multicellular organism growth |
| A | 0045159 | molecular_function | myosin II binding |
| A | 0045197 | biological_process | establishment or maintenance of epithelial cell apical/basal polarity |
| A | 0051294 | biological_process | establishment of spindle orientation |
| A | 0051301 | biological_process | cell division |
| A | 0060670 | biological_process | branching involved in labyrinthine layer morphogenesis |
| A | 0060716 | biological_process | labyrinthine layer blood vessel development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1001 |
| Chain | Residue |
| A | LYS514 |
| A | LYS801 |
| A | TYR906 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLTGheDgTVRFWDA |
| Chain | Residue | Details |
| A | LEU438-ALA452 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"WD 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 75 |
| Details | Repeat: {"description":"WD 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 56 |
| Details | Repeat: {"description":"WD 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"WD 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"WD 14"} |
| Chain | Residue | Details |
