6N7W
Structure of bacteriophage T7 leading-strand DNA polymerase (D5A/E7A)/Trx in complex with a DNA fork and incoming dTTP (from multiple lead complexes)
Functional Information from GO Data
Chain | GOid | namespace | contents |
H | 0000166 | molecular_function | nucleotide binding |
H | 0003676 | molecular_function | nucleic acid binding |
H | 0003677 | molecular_function | DNA binding |
H | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
H | 0004527 | molecular_function | exonuclease activity |
H | 0004529 | molecular_function | DNA exonuclease activity |
H | 0005515 | molecular_function | protein binding |
H | 0006260 | biological_process | DNA replication |
H | 0006261 | biological_process | DNA-templated DNA replication |
H | 0006302 | biological_process | double-strand break repair |
H | 0008408 | molecular_function | 3'-5' exonuclease activity |
H | 0039693 | biological_process | viral DNA genome replication |
H | 0046872 | molecular_function | metal ion binding |
H | 0090592 | biological_process | DNA synthesis involved in DNA replication |
I | 0005515 | molecular_function | protein binding |
I | 0005737 | cellular_component | cytoplasm |
I | 0005829 | cellular_component | cytosol |
I | 0015035 | molecular_function | protein-disulfide reductase activity |
I | 0015036 | molecular_function | disulfide oxidoreductase activity |
I | 0030337 | molecular_function | DNA polymerase processivity factor activity |
I | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue MG H 4001 |
Chain | Residue |
H | ASP475 |
H | ALA476 |
H | ASP654 |
H | TTP4002 |
site_id | AC2 |
Number of Residues | 14 |
Details | binding site for residue TTP H 4002 |
Chain | Residue |
H | GLU480 |
H | HIS506 |
H | ARG518 |
H | LYS522 |
H | TYR526 |
H | ASP654 |
H | MG4001 |
P | 2DA25 |
T | DT53 |
H | ARG429 |
H | ASP475 |
H | ALA476 |
H | SER477 |
H | GLY478 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
I | CYS32 | |
I | CYS35 | |
H | ASP174 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Deprotonates C-terminal active site Cys |
Chain | Residue | Details |
I | ASP26 | |
H | ALA476 | |
H | ASP654 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Contributes to redox potential value |
Chain | Residue | Details |
I | GLY33 | |
I | PRO34 | |
H | LYS522 | |
H | TYR526 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
I | LYS69 |