6N7W

Structure of bacteriophage T7 leading-strand DNA polymerase (D5A/E7A)/Trx in complex with a DNA fork and incoming dTTP (from multiple lead complexes)

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000166	molecular_function	nucleotide binding
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0003824	molecular_function	catalytic activity
H	0003887	molecular_function	DNA-directed DNA polymerase activity
H	0004518	molecular_function	nuclease activity
H	0004527	molecular_function	exonuclease activity
H	0004529	molecular_function	DNA exonuclease activity
H	0005515	molecular_function	protein binding
H	0006260	biological_process	DNA replication
H	0006261	biological_process	DNA-templated DNA replication
H	0008152	biological_process	metabolic process
H	0008408	molecular_function	3'-5' exonuclease activity
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0016787	molecular_function	hydrolase activity
H	0039693	biological_process	viral DNA genome replication
H	0046872	molecular_function	metal ion binding
H	0090592	biological_process	DNA synthesis involved in DNA replication
H	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0015035	molecular_function	protein-disulfide reductase activity
I	0015036	molecular_function	disulfide oxidoreductase activity
I	0030337	molecular_function	DNA polymerase processivity factor activity
I	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG H 4001

Chain	Residue
H	ASP475
H	ALA476
H	ASP654
H	TTP4002

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site_id	AC2
Number of Residues	14
Details	binding site for residue TTP H 4002

Chain	Residue
H	GLU480
H	HIS506
H	ARG518
H	LYS522
H	TYR526
H	ASP654
H	MG4001
P	2DA25
T	DT53
H	ARG429
H	ASP475
H	ALA476
H	SER477
H	GLY478

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Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL

Chain	Residue	Details
I	LEU24-LEU42

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site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI

Chain	Residue	Details
H	ARG518-ILE537

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
I	CYS32
I	CYS35
H	ASP174

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Deprotonates C-terminal active site Cys

Chain	Residue	Details
I	ASP26
H	ALA476
H	ASP654

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Contributes to redox potential value

Chain	Residue	Details
I	GLY33
I	PRO34
H	LYS522
H	TYR526

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
I	LYS69

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