6N55
Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004849 | molecular_function | uridine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007631 | biological_process | feeding behavior |
| A | 0009224 | biological_process | CMP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043771 | molecular_function | cytidine kinase activity |
| A | 0044206 | biological_process | UMP salvage |
| A | 0044211 | biological_process | CTP salvage |
| A | 0048678 | biological_process | response to axon injury |
| A | 0071453 | biological_process | cellular response to oxygen levels |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004849 | molecular_function | uridine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007631 | biological_process | feeding behavior |
| B | 0009224 | biological_process | CMP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043771 | molecular_function | cytidine kinase activity |
| B | 0044206 | biological_process | UMP salvage |
| B | 0044211 | biological_process | CTP salvage |
| B | 0048678 | biological_process | response to axon injury |
| B | 0071453 | biological_process | cellular response to oxygen levels |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004849 | molecular_function | uridine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0007631 | biological_process | feeding behavior |
| C | 0009224 | biological_process | CMP biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043771 | molecular_function | cytidine kinase activity |
| C | 0044206 | biological_process | UMP salvage |
| C | 0044211 | biological_process | CTP salvage |
| C | 0048678 | biological_process | response to axon injury |
| C | 0071453 | biological_process | cellular response to oxygen levels |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004849 | molecular_function | uridine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0007631 | biological_process | feeding behavior |
| D | 0009224 | biological_process | CMP biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043771 | molecular_function | cytidine kinase activity |
| D | 0044206 | biological_process | UMP salvage |
| D | 0044211 | biological_process | CTP salvage |
| D | 0048678 | biological_process | response to axon injury |
| D | 0071453 | biological_process | cellular response to oxygen levels |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004849 | molecular_function | uridine kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0007631 | biological_process | feeding behavior |
| E | 0009224 | biological_process | CMP biosynthetic process |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043771 | molecular_function | cytidine kinase activity |
| E | 0044206 | biological_process | UMP salvage |
| E | 0044211 | biological_process | CTP salvage |
| E | 0048678 | biological_process | response to axon injury |
| E | 0071453 | biological_process | cellular response to oxygen levels |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004849 | molecular_function | uridine kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0007631 | biological_process | feeding behavior |
| F | 0009224 | biological_process | CMP biosynthetic process |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043771 | molecular_function | cytidine kinase activity |
| F | 0044206 | biological_process | UMP salvage |
| F | 0044211 | biological_process | CTP salvage |
| F | 0048678 | biological_process | response to axon injury |
| F | 0071453 | biological_process | cellular response to oxygen levels |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004849 | molecular_function | uridine kinase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0007631 | biological_process | feeding behavior |
| G | 0009224 | biological_process | CMP biosynthetic process |
| G | 0016301 | molecular_function | kinase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043771 | molecular_function | cytidine kinase activity |
| G | 0044206 | biological_process | UMP salvage |
| G | 0044211 | biological_process | CTP salvage |
| G | 0048678 | biological_process | response to axon injury |
| G | 0071453 | biological_process | cellular response to oxygen levels |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0004849 | molecular_function | uridine kinase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0007631 | biological_process | feeding behavior |
| H | 0009224 | biological_process | CMP biosynthetic process |
| H | 0016301 | molecular_function | kinase activity |
| H | 0016740 | molecular_function | transferase activity |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043771 | molecular_function | cytidine kinase activity |
| H | 0044206 | biological_process | UMP salvage |
| H | 0044211 | biological_process | CTP salvage |
| H | 0048678 | biological_process | response to axon injury |
| H | 0071453 | biological_process | cellular response to oxygen levels |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 301 |
| Chain | Residue |
| A | THR29 |
| A | ALA30 |
| A | SER31 |
| A | GLY32 |
| A | LYS33 |
| A | SER34 |
| A | ARG169 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | TYR203 |
| A | PRO199 |
| A | LYS202 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | SER164 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | GLN61 |
| A | ASN91 |
| A | LEU138 |
| A | SER142 |
| A | VAL145 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | PHE81 |
| A | HIS85 |
| A | ASP87 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| B | THR29 |
| B | ALA30 |
| B | SER31 |
| B | GLY32 |
| B | LYS33 |
| B | SER34 |
| B | ARG169 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | PHE81 |
| B | ASN82 |
| B | ASP87 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | PRO199 |
| B | LYS202 |
| B | TYR203 |
| B | HOH405 |
| E | GLU195 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| B | TYR65 |
| B | TYR112 |
| B | SER116 |
| B | SER118 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 C 301 |
| Chain | Residue |
| C | GLY28 |
| C | THR29 |
| C | ALA30 |
| C | SER31 |
| C | GLY32 |
| C | LYS33 |
| C | SER34 |
| C | ARG169 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| A | LEU182 |
| A | ILE186 |
| C | SER164 |
| C | LEU168 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 303 |
| Chain | Residue |
| C | PRO128 |
| C | ASP130 |
| C | HOH402 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 304 |
| Chain | Residue |
| C | GLN61 |
| C | PRO86 |
| C | ASN91 |
| C | ILE94 |
| C | LEU138 |
| C | ALA139 |
| C | SER142 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue GOL C 305 |
| Chain | Residue |
| C | LYS202 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 301 |
| Chain | Residue |
| D | THR29 |
| D | ALA30 |
| D | SER31 |
| D | GLY32 |
| D | LYS33 |
| D | SER34 |
| D | ARG169 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| B | GLU194 |
| D | ASP158 |
| D | ALA159 |
| D | ASP160 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| D | GLN61 |
| D | PRO86 |
| D | ASN91 |
| D | LEU138 |
| D | SER142 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 304 |
| Chain | Residue |
| D | PRO128 |
| D | ASP130 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 305 |
| Chain | Residue |
| D | ASP227 |
| E | GLY231 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL D 306 |
| Chain | Residue |
| D | ARG169 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 307 |
| Chain | Residue |
| D | LYS96 |
| D | GLU100 |
| D | VAL107 |
| D | GLN108 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue UZ0 D 308 |
| Chain | Residue |
| D | THR29 |
| D | TYR65 |
| D | PHE81 |
| D | PHE83 |
| D | ASP84 |
| D | ARG166 |
| D | GLN184 |
| D | PHE188 |
| D | VAL189 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 E 301 |
| Chain | Residue |
| E | SER34 |
| E | ALA30 |
| E | SER31 |
| E | GLY32 |
| E | LYS33 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 302 |
| Chain | Residue |
| D | ILE207 |
| E | ASP156 |
| E | ASP158 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL E 303 |
| Chain | Residue |
| E | SER183 |
| G | SER164 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 304 |
| Chain | Residue |
| E | TYR141 |
| E | PRO199 |
| E | LYS202 |
| E | TYR203 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 305 |
| Chain | Residue |
| E | GLN61 |
| E | PRO86 |
| E | ASN91 |
| E | LEU138 |
| E | SER142 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 F 301 |
| Chain | Residue |
| F | GLY28 |
| F | THR29 |
| F | ALA30 |
| F | SER31 |
| F | GLY32 |
| F | LYS33 |
| F | SER34 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL F 302 |
| Chain | Residue |
| F | GLU100 |
| F | GLU103 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 303 |
| Chain | Residue |
| F | GLU179 |
| F | SER183 |
| F | ILE186 |
| H | SER164 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL F 304 |
| Chain | Residue |
| F | GLN61 |
| F | PRO86 |
| F | PHE89 |
| F | ASN91 |
| F | ILE94 |
| F | LEU138 |
| F | SER142 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 305 |
| Chain | Residue |
| F | LEU93 |
| F | GLU100 |
| F | VAL107 |
| F | GLN108 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL F 306 |
| Chain | Residue |
| F | LYS99 |
| F | GLU103 |
| F | LEU148 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue UZ0 F 307 |
| Chain | Residue |
| E | SER172 |
| E | GLU173 |
| F | TYR65 |
| F | ASP84 |
| F | PHE114 |
| F | ARG174 |
| F | HOH401 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 G 301 |
| Chain | Residue |
| G | ALA30 |
| G | SER31 |
| G | GLY32 |
| G | LYS33 |
| G | SER34 |
| G | ARG169 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL G 302 |
| Chain | Residue |
| E | SER164 |
| G | SER183 |
| G | ILE186 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 H 301 |
| Chain | Residue |
| H | GLY28 |
| H | THR29 |
| H | ALA30 |
| H | SER31 |
| H | GLY32 |
| H | LYS33 |
| H | SER34 |
| H | ARG169 |
| site_id | AG2 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide UZR E 306 and ARG E 174 |
| Chain | Residue |
| E | PHE83 |
| E | ARG169 |
| E | ASP170 |
| E | SER172 |
| E | GLU173 |
| E | GLY175 |
| E | ARG176 |
| F | GLU173 |
| F | ARG174 |
| F | GLY175 |
| F | ARG176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 119 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15130468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15735337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
