6MZG
Structural Basis of Tubulin Recruitment and Assembly by Microtubule Polymerases with Tumor Overexpressed Gene (TOG) Domain Arrays
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000226 | biological_process | microtubule cytoskeleton organization |
| C | 0000278 | biological_process | mitotic cell cycle |
| C | 0005200 | molecular_function | structural constituent of cytoskeleton |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005874 | cellular_component | microtubule |
| C | 0007017 | biological_process | microtubule-based process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000226 | biological_process | microtubule cytoskeleton organization |
| D | 0000278 | biological_process | mitotic cell cycle |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005200 | molecular_function | structural constituent of cytoskeleton |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005874 | cellular_component | microtubule |
| D | 0007017 | biological_process | microtubule-based process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000776 | cellular_component | kinetochore |
| E | 0000922 | cellular_component | spindle pole |
| E | 0005816 | cellular_component | spindle pole body |
| E | 0007051 | biological_process | spindle organization |
| E | 0007052 | biological_process | mitotic spindle organization |
| E | 0008017 | molecular_function | microtubule binding |
| E | 0015631 | molecular_function | tubulin binding |
| E | 0030951 | biological_process | establishment or maintenance of microtubule cytoskeleton polarity |
| E | 0035371 | cellular_component | microtubule plus-end |
| E | 0043232 | cellular_component | intracellular non-membrane-bounded organelle |
| E | 0046785 | biological_process | microtubule polymerization |
| E | 0051010 | molecular_function | microtubule plus-end binding |
| E | 0061863 | molecular_function | microtubule plus end polymerase |
| E | 0099080 | cellular_component | supramolecular complex |
| G | 0000226 | biological_process | microtubule cytoskeleton organization |
| G | 0000278 | biological_process | mitotic cell cycle |
| G | 0005200 | molecular_function | structural constituent of cytoskeleton |
| G | 0005525 | molecular_function | GTP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005856 | cellular_component | cytoskeleton |
| G | 0005874 | cellular_component | microtubule |
| G | 0007017 | biological_process | microtubule-based process |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000226 | biological_process | microtubule cytoskeleton organization |
| H | 0000278 | biological_process | mitotic cell cycle |
| H | 0003924 | molecular_function | GTPase activity |
| H | 0005200 | molecular_function | structural constituent of cytoskeleton |
| H | 0005515 | molecular_function | protein binding |
| H | 0005525 | molecular_function | GTP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005856 | cellular_component | cytoskeleton |
| H | 0005874 | cellular_component | microtubule |
| H | 0007017 | biological_process | microtubule-based process |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0000226 | biological_process | microtubule cytoskeleton organization |
| I | 0000278 | biological_process | mitotic cell cycle |
| I | 0005200 | molecular_function | structural constituent of cytoskeleton |
| I | 0005525 | molecular_function | GTP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005856 | cellular_component | cytoskeleton |
| I | 0005874 | cellular_component | microtubule |
| I | 0007017 | biological_process | microtubule-based process |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0000226 | biological_process | microtubule cytoskeleton organization |
| J | 0000278 | biological_process | mitotic cell cycle |
| J | 0003924 | molecular_function | GTPase activity |
| J | 0005200 | molecular_function | structural constituent of cytoskeleton |
| J | 0005515 | molecular_function | protein binding |
| J | 0005525 | molecular_function | GTP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005856 | cellular_component | cytoskeleton |
| J | 0005874 | cellular_component | microtubule |
| J | 0007017 | biological_process | microtubule-based process |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0000776 | cellular_component | kinetochore |
| K | 0000922 | cellular_component | spindle pole |
| K | 0005816 | cellular_component | spindle pole body |
| K | 0007051 | biological_process | spindle organization |
| K | 0007052 | biological_process | mitotic spindle organization |
| K | 0008017 | molecular_function | microtubule binding |
| K | 0015631 | molecular_function | tubulin binding |
| K | 0030951 | biological_process | establishment or maintenance of microtubule cytoskeleton polarity |
| K | 0035371 | cellular_component | microtubule plus-end |
| K | 0043232 | cellular_component | intracellular non-membrane-bounded organelle |
| K | 0046785 | biological_process | microtubule polymerization |
| K | 0051010 | molecular_function | microtubule plus-end binding |
| K | 0061863 | molecular_function | microtubule plus end polymerase |
| K | 0099080 | cellular_component | supramolecular complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue GTP A 600 |
| Chain | Residue |
| A | GLY10 |
| A | GLY143 |
| A | GLY144 |
| A | THR145 |
| A | GLY146 |
| A | VAL177 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | ASN228 |
| A | MG601 |
| A | GLN11 |
| B | LYS254 |
| A | ALA12 |
| A | GLN15 |
| A | ASP98 |
| A | ALA99 |
| A | ALA100 |
| A | ASN101 |
| A | SER140 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 601 |
| Chain | Residue |
| A | GLU71 |
| A | GTP600 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue GDP B 600 |
| Chain | Residue |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | ASN101 |
| B | SER140 |
| B | GLY143 |
| B | GLY144 |
| B | THR145 |
| B | GLY146 |
| B | VAL177 |
| B | GLU183 |
| B | ASN206 |
| B | TYR224 |
| B | ASN228 |
| B | MG601 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 601 |
| Chain | Residue |
| B | GLN11 |
| B | ASP179 |
| B | GDP600 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue GTP C 600 |
| Chain | Residue |
| C | GLY10 |
| C | GLN11 |
| C | ALA12 |
| C | GLN15 |
| C | ASP98 |
| C | ALA99 |
| C | ALA100 |
| C | ASN101 |
| C | SER140 |
| C | GLY143 |
| C | GLY144 |
| C | THR145 |
| C | GLY146 |
| C | VAL177 |
| C | GLU183 |
| C | ASN206 |
| C | TYR224 |
| C | ASN228 |
| C | ILE231 |
| C | MG601 |
| D | LYS254 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 601 |
| Chain | Residue |
| C | GLU71 |
| C | GTP600 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue GDP D 600 |
| Chain | Residue |
| D | GLY10 |
| D | GLN11 |
| D | CYS12 |
| D | GLN15 |
| D | ASN101 |
| D | SER140 |
| D | GLY143 |
| D | GLY144 |
| D | THR145 |
| D | GLY146 |
| D | VAL177 |
| D | GLU183 |
| D | ASN206 |
| D | TYR224 |
| D | ASN228 |
| D | MG601 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 601 |
| Chain | Residue |
| D | GLN11 |
| D | GDP600 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | binding site for residue GTP G 600 |
| Chain | Residue |
| G | TYR224 |
| G | ASN228 |
| G | ILE231 |
| G | MG601 |
| H | LYS254 |
| G | GLY10 |
| G | GLN11 |
| G | ALA12 |
| G | GLN15 |
| G | ASP98 |
| G | ALA99 |
| G | ALA100 |
| G | ASN101 |
| G | SER140 |
| G | GLY143 |
| G | GLY144 |
| G | THR145 |
| G | GLY146 |
| G | ILE171 |
| G | VAL177 |
| G | GLU183 |
| G | ASN206 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue MG G 601 |
| Chain | Residue |
| G | GLU71 |
| G | GTP600 |
| site_id | AD2 |
| Number of Residues | 17 |
| Details | binding site for residue GDP H 600 |
| Chain | Residue |
| H | GLY10 |
| H | GLN11 |
| H | CYS12 |
| H | GLN15 |
| H | ASN101 |
| H | SER140 |
| H | GLY143 |
| H | GLY144 |
| H | THR145 |
| H | GLY146 |
| H | VAL177 |
| H | ASP179 |
| H | GLU183 |
| H | ASN206 |
| H | TYR224 |
| H | ASN228 |
| H | MG601 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue MG H 601 |
| Chain | Residue |
| H | GLN11 |
| H | ASN101 |
| H | ASP179 |
| H | GDP600 |
| site_id | AD4 |
| Number of Residues | 20 |
| Details | binding site for residue GTP I 600 |
| Chain | Residue |
| I | GLY10 |
| I | GLN11 |
| I | ALA12 |
| I | GLN15 |
| I | ASP98 |
| I | ALA99 |
| I | ALA100 |
| I | ASN101 |
| I | SER140 |
| I | GLY143 |
| I | GLY144 |
| I | THR145 |
| I | GLY146 |
| I | VAL177 |
| I | GLU183 |
| I | ASN206 |
| I | TYR224 |
| I | ASN228 |
| I | MG601 |
| J | LYS254 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue MG I 601 |
| Chain | Residue |
| I | GLU71 |
| I | GTP600 |
| site_id | AD6 |
| Number of Residues | 17 |
| Details | binding site for residue GDP J 600 |
| Chain | Residue |
| J | GLY10 |
| J | GLN11 |
| J | CYS12 |
| J | GLN15 |
| J | ASN101 |
| J | SER140 |
| J | GLY143 |
| J | GLY144 |
| J | THR145 |
| J | GLY146 |
| J | PRO173 |
| J | VAL177 |
| J | GLU183 |
| J | ASN206 |
| J | TYR224 |
| J | ASN228 |
| J | MG601 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue MG J 601 |
| Chain | Residue |
| J | GLN11 |
| J | GDP600 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q13509 |
| Chain | Residue | Details |
| B | GLN11 | |
| D | GLY144 | |
| D | THR145 | |
| D | GLY146 | |
| D | ASN206 | |
| D | ASN228 | |
| H | GLN11 | |
| H | SER140 | |
| H | GLY144 | |
| H | THR145 | |
| H | GLY146 | |
| B | SER140 | |
| H | ASN206 | |
| H | ASN228 | |
| J | GLN11 | |
| J | SER140 | |
| J | GLY144 | |
| J | THR145 | |
| J | GLY146 | |
| J | ASN206 | |
| J | ASN228 | |
| B | GLY144 | |
| B | THR145 | |
| B | GLY146 | |
| B | ASN206 | |
| B | ASN228 | |
| D | GLN11 | |
| D | SER140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| B | GLU71 | |
| C | GLU71 | |
| C | SER140 | |
| C | GLY144 | |
| C | THR145 | |
| C | THR179 | |
| C | ASN206 | |
| C | ASN228 | |
| G | GLN11 | |
| G | GLU71 | |
| G | SER140 | |
| D | GLU71 | |
| G | GLY144 | |
| G | THR145 | |
| G | THR179 | |
| G | ASN206 | |
| G | ASN228 | |
| I | GLN11 | |
| I | GLU71 | |
| I | SER140 | |
| I | GLY144 | |
| I | THR145 | |
| H | GLU71 | |
| I | THR179 | |
| I | ASN206 | |
| I | ASN228 | |
| J | GLU71 | |
| A | THR145 | |
| A | THR179 | |
| A | ASN206 | |
| A | ASN228 | |
| C | GLN11 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024 |
| Chain | Residue | Details |
| B | SER40 | |
| D | SER40 | |
| H | SER40 | |
| J | SER40 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024 |
| Chain | Residue | Details |
| B | LYS60 | |
| D | LYS60 | |
| H | LYS60 | |
| J | LYS60 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q13885 |
| Chain | Residue | Details |
| B | SER174 | |
| D | SER174 | |
| H | SER174 | |
| J | SER174 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| B | THR287 | |
| B | THR292 | |
| D | THR287 | |
| D | THR292 | |
| H | THR287 | |
| H | THR292 | |
| J | THR287 | |
| J | THR292 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| B | ARG320 | |
| D | ARG320 | |
| H | ARG320 | |
| J | ARG320 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0 |
| Chain | Residue | Details |
| B | GLU448 | |
| D | GLU448 | |
| H | GLU448 | |
| J | GLU448 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| B | LYS60 | |
| D | LYS60 | |
| H | LYS60 | |
| J | LYS60 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| B | LYS326 | |
| D | LYS326 | |
| H | LYS326 | |
| J | LYS326 |
