6MZD

Human TFIID Lobe A canonical

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0000785	cellular_component	chromatin
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
A	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
A	0002039	molecular_function	p53 binding
A	0003677	molecular_function	DNA binding
A	0004402	molecular_function	histone acetyltransferase activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005669	cellular_component	transcription factor TFIID complex
A	0005730	cellular_component	nucleolus
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006352	biological_process	DNA-templated transcription initiation
A	0006361	biological_process	transcription initiation at RNA polymerase I promoter
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0010629	biological_process	negative regulation of gene expression
A	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016922	molecular_function	nuclear receptor binding
A	0017025	molecular_function	TBP-class protein binding
A	0030901	biological_process	midbrain development
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0034644	biological_process	cellular response to UV
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046777	biological_process	protein autophosphorylation
A	0046982	molecular_function	protein heterodimerization activity
A	0050821	biological_process	protein stabilization
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0061628	molecular_function	histone H3K27me3 reader activity
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0061733	molecular_function	protein-lysine-acetyltransferase activity
A	0071318	biological_process	cellular response to ATP
A	0071339	cellular_component	MLL1 complex
A	0106310	molecular_function	protein serine kinase activity
A	0140046	molecular_function	histone H4K16ac reader activity
A	0140416	molecular_function	transcription regulator inhibitor activity
A	0140566	molecular_function	histone reader activity
A	0160207	biological_process	positive regulation of androgen receptor signaling pathway
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
A	1902806	biological_process	regulation of cell cycle G1/S phase transition
A	1905502	molecular_function	acetyl-CoA binding
A	1905524	biological_process	negative regulation of protein autoubiquitination
A	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001673	cellular_component	male germ cell nucleus
C	0002039	molecular_function	p53 binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005669	cellular_component	transcription factor TFIID complex
C	0006325	biological_process	chromatin organization
C	0006366	biological_process	transcription by RNA polymerase II
C	0008270	molecular_function	zinc ion binding
C	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
C	0031965	cellular_component	nuclear membrane
C	0042789	biological_process	mRNA transcription by RNA polymerase II
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0051123	biological_process	RNA polymerase II preinitiation complex assembly
C	0051457	biological_process	maintenance of protein location in nucleus
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0140002	molecular_function	histone H3K4me3 reader activity
C	0140416	molecular_function	transcription regulator inhibitor activity
C	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
D	0000785	cellular_component	chromatin
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001541	biological_process	ovarian follicle development
D	0001673	cellular_component	male germ cell nucleus
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005669	cellular_component	transcription factor TFIID complex
D	0005829	cellular_component	cytosol
D	0006282	biological_process	regulation of DNA repair
D	0006351	biological_process	DNA-templated transcription
D	0006352	biological_process	DNA-templated transcription initiation
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0017162	molecular_function	aryl hydrocarbon receptor binding
D	0032991	cellular_component	protein-containing complex
D	0033276	cellular_component	transcription factor TFTC complex
D	0042789	biological_process	mRNA transcription by RNA polymerase II
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046982	molecular_function	protein heterodimerization activity
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0071339	cellular_component	MLL1 complex
F	0000785	cellular_component	chromatin
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005730	cellular_component	nucleolus
F	0006282	biological_process	regulation of DNA repair
F	0006352	biological_process	DNA-templated transcription initiation
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0015629	cellular_component	actin cytoskeleton
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0033276	cellular_component	transcription factor TFTC complex
F	0042789	biological_process	mRNA transcription by RNA polymerase II
F	0042802	molecular_function	identical protein binding
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0000124	cellular_component	SAGA complex
H	0003677	molecular_function	DNA binding
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005669	cellular_component	transcription factor TFIID complex
H	0005829	cellular_component	cytosol
H	0006282	biological_process	regulation of DNA repair
H	0006352	biological_process	DNA-templated transcription initiation
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006915	biological_process	apoptotic process
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0017162	molecular_function	aryl hydrocarbon receptor binding
H	0032991	cellular_component	protein-containing complex
H	0033276	cellular_component	transcription factor TFTC complex
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0045786	biological_process	negative regulation of cell cycle
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0046695	cellular_component	SLIK (SAGA-like) complex
H	0046982	molecular_function	protein heterodimerization activity
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0071339	cellular_component	MLL1 complex
L	0000124	cellular_component	SAGA complex
L	0000492	biological_process	box C/D snoRNP assembly
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0002039	molecular_function	p53 binding
L	0003677	molecular_function	DNA binding
L	0003713	molecular_function	transcription coactivator activity
L	0004402	molecular_function	histone acetyltransferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005669	cellular_component	transcription factor TFIID complex
L	0006282	biological_process	regulation of DNA repair
L	0006338	biological_process	chromatin remodeling
L	0006352	biological_process	DNA-templated transcription initiation
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006974	biological_process	DNA damage response
L	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
L	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0033276	cellular_component	transcription factor TFTC complex
L	0042789	biological_process	mRNA transcription by RNA polymerase II
L	0043066	biological_process	negative regulation of apoptotic process
L	0043484	biological_process	regulation of RNA splicing
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046982	molecular_function	protein heterodimerization activity
L	0050821	biological_process	protein stabilization
L	0051117	molecular_function	ATPase binding
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0060760	biological_process	positive regulation of response to cytokine stimulus
L	0070555	biological_process	response to interleukin-1
L	0070742	molecular_function	C2H2 zinc finger domain binding
L	0070761	cellular_component	pre-snoRNP complex
L	0071339	cellular_component	MLL1 complex
L	0140297	molecular_function	DNA-binding transcription factor binding
L	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
N	0000082	biological_process	G1/S transition of mitotic cell cycle
N	0000124	cellular_component	SAGA complex
N	0001673	cellular_component	male germ cell nucleus
N	0001701	biological_process	in utero embryonic development
N	0001756	biological_process	somitogenesis
N	0001889	biological_process	liver development
N	0001892	biological_process	embryonic placenta development
N	0003677	molecular_function	DNA binding
N	0004402	molecular_function	histone acetyltransferase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005669	cellular_component	transcription factor TFIID complex
N	0005737	cellular_component	cytoplasm
N	0006282	biological_process	regulation of DNA repair
N	0006338	biological_process	chromatin remodeling
N	0006352	biological_process	DNA-templated transcription initiation
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006366	biological_process	transcription by RNA polymerase II
N	0006367	biological_process	transcription initiation at RNA polymerase II promoter
N	0006915	biological_process	apoptotic process
N	0010467	biological_process	gene expression
N	0010468	biological_process	regulation of gene expression
N	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
N	0019899	molecular_function	enzyme binding
N	0030331	molecular_function	nuclear estrogen receptor binding
N	0033276	cellular_component	transcription factor TFTC complex
N	0035264	biological_process	multicellular organism growth
N	0036285	biological_process	SAGA complex assembly
N	0042789	biological_process	mRNA transcription by RNA polymerase II
N	0042802	molecular_function	identical protein binding
N	0043484	biological_process	regulation of RNA splicing
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0048371	biological_process	lateral mesodermal cell differentiation
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060173	biological_process	limb development
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0065003	biological_process	protein-containing complex assembly
N	0070063	molecular_function	RNA polymerase binding
N	0070365	biological_process	hepatocyte differentiation
N	0097550	cellular_component	transcription preinitiation complex
N	1905069	biological_process	allantois development
N	1990841	molecular_function	promoter-specific chromatin binding
P	0003713	molecular_function	transcription coactivator activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005669	cellular_component	transcription factor TFIID complex
P	0005794	cellular_component	Golgi apparatus
P	0006366	biological_process	transcription by RNA polymerase II
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
P	0017025	molecular_function	TBP-class protein binding
P	0042789	biological_process	mRNA transcription by RNA polymerase II
P	0042809	molecular_function	nuclear vitamin D receptor binding
P	0043923	biological_process	positive regulation by host of viral transcription
P	0046966	molecular_function	nuclear thyroid hormone receptor binding
P	0046982	molecular_function	protein heterodimerization activity
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0000124	cellular_component	SAGA complex
Q	0003677	molecular_function	DNA binding
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005669	cellular_component	transcription factor TFIID complex
Q	0006282	biological_process	regulation of DNA repair
Q	0006352	biological_process	DNA-templated transcription initiation
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Q	0017025	molecular_function	TBP-class protein binding
Q	0033276	cellular_component	transcription factor TFTC complex
Q	0042789	biological_process	mRNA transcription by RNA polymerase II
Q	0043484	biological_process	regulation of RNA splicing
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046982	molecular_function	protein heterodimerization activity
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0140297	molecular_function	DNA-binding transcription factor binding
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005669	cellular_component	transcription factor TFIID complex
S	0005730	cellular_component	nucleolus
S	0006352	biological_process	DNA-templated transcription initiation
S	0006366	biological_process	transcription by RNA polymerase II
S	0006367	biological_process	transcription initiation at RNA polymerase II promoter
S	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
S	0017025	molecular_function	TBP-class protein binding
S	0042789	biological_process	mRNA transcription by RNA polymerase II
S	0046982	molecular_function	protein heterodimerization activity
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0000785	cellular_component	chromatin
T	0000791	cellular_component	euchromatin
T	0000976	molecular_function	transcription cis-regulatory region binding
T	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
T	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
T	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
T	0001046	molecular_function	core promoter sequence-specific DNA binding
T	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
T	0001093	molecular_function	TFIIB-class transcription factor binding
T	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
T	0001188	biological_process	RNA polymerase I preinitiation complex assembly
T	0001673	cellular_component	male germ cell nucleus
T	0001674	cellular_component	female germ cell nucleus
T	0001939	cellular_component	female pronucleus
T	0001940	cellular_component	male pronucleus
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
T	0005669	cellular_component	transcription factor TFIID complex
T	0005672	cellular_component	transcription factor TFIIA complex
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006352	biological_process	DNA-templated transcription initiation
T	0006366	biological_process	transcription by RNA polymerase II
T	0006367	biological_process	transcription initiation at RNA polymerase II promoter
T	0006383	biological_process	transcription by RNA polymerase III
T	0007283	biological_process	spermatogenesis
T	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
T	0017162	molecular_function	aryl hydrocarbon receptor binding
T	0019899	molecular_function	enzyme binding
T	0032991	cellular_component	protein-containing complex
T	0042789	biological_process	mRNA transcription by RNA polymerase II
T	0045120	cellular_component	pronucleus
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0051123	biological_process	RNA polymerase II preinitiation complex assembly
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
T	0140297	molecular_function	DNA-binding transcription factor binding

Functional Information from PROSITE/UniProt

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
T	TYR192-VAL241
T	TYR283-LEU332

---

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. TypFhtpvNakvvk..DYYkiItrpMdlqtLrenvrkrl..Ypsreefrehlel.IvkNSatY

Chain	Residue	Details
A	THR1423-TYR1480
A	SER1546-TYR1603

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGsaDrTVRLWDV

Chain	Residue	Details
F	VAL642-VAL656
F	LEU684-ILE698
F	LEU726-ALA740

---

site_id	PS01359
Number of Residues	45
Details	ZF_PHD_1 Zinc finger PHD-type signature. CpgCnkpddgspm....................................IgCdd..Cddw.YHwpCvgimtappeemq.................................WfCpkC

Chain	Residue	Details
C	CYS895-CYS939

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IYD

Chain	Residue	Details
T	ASN167
T	ARG203
T	LYS218
T	ASN257
T	ARG294

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
Q	SER51
D	ARG435
C	CYS910
C	CYS913
C	HIS918
C	CYS921
C	CYS936
C	CYS939

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
Q	THR59
D	LYS595
D	LYS597
D	LYS605
D	LYS611
D	LYS621
D	LYS631
D	LYS658

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
Q	LYS19
L	SER196
C	SER782

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
L	SER155
C	SER270
A	SER1799
A	SER1802
A	SER1820

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
L	SER158
C	LYS803

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
L	THR159
H	SER636
A	LYS583

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
L	THR161
C	SER328

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
L	THR164

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR178

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
L	SER181
C	LYS773

---