6MZC

Human TFIID BC core

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0006282	biological_process	regulation of DNA repair
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0014070	biological_process	response to organic cyclic compound
B	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
B	0033276	cellular_component	transcription factor TFTC complex
B	0042789	biological_process	mRNA transcription by RNA polymerase II
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0000785	cellular_component	chromatin
E	0001046	molecular_function	core promoter sequence-specific DNA binding
E	0001541	biological_process	ovarian follicle development
E	0001673	cellular_component	male germ cell nucleus
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005667	cellular_component	transcription regulator complex
E	0005669	cellular_component	transcription factor TFIID complex
E	0005829	cellular_component	cytosol
E	0006282	biological_process	regulation of DNA repair
E	0006351	biological_process	DNA-templated transcription
E	0006352	biological_process	DNA-templated transcription initiation
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
E	0017162	molecular_function	aryl hydrocarbon receptor binding
E	0032991	cellular_component	protein-containing complex
E	0033276	cellular_component	transcription factor TFTC complex
E	0042789	biological_process	mRNA transcription by RNA polymerase II
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0046982	molecular_function	protein heterodimerization activity
E	0051123	biological_process	RNA polymerase II preinitiation complex assembly
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0071339	cellular_component	MLL1 complex
G	0000785	cellular_component	chromatin
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005669	cellular_component	transcription factor TFIID complex
G	0005730	cellular_component	nucleolus
G	0006282	biological_process	regulation of DNA repair
G	0006352	biological_process	DNA-templated transcription initiation
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0015629	cellular_component	actin cytoskeleton
G	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
G	0033276	cellular_component	transcription factor TFTC complex
G	0042789	biological_process	mRNA transcription by RNA polymerase II
G	0042802	molecular_function	identical protein binding
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0000124	cellular_component	SAGA complex
H	0003677	molecular_function	DNA binding
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005669	cellular_component	transcription factor TFIID complex
H	0005829	cellular_component	cytosol
H	0006282	biological_process	regulation of DNA repair
H	0006352	biological_process	DNA-templated transcription initiation
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006915	biological_process	apoptotic process
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0017162	molecular_function	aryl hydrocarbon receptor binding
H	0032991	cellular_component	protein-containing complex
H	0033276	cellular_component	transcription factor TFTC complex
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0045786	biological_process	negative regulation of cell cycle
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0046695	cellular_component	SLIK (SAGA-like) complex
H	0046982	molecular_function	protein heterodimerization activity
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0071339	cellular_component	MLL1 complex
I	0000124	cellular_component	SAGA complex
I	0003677	molecular_function	DNA binding
I	0003713	molecular_function	transcription coactivator activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005669	cellular_component	transcription factor TFIID complex
I	0005829	cellular_component	cytosol
I	0006282	biological_process	regulation of DNA repair
I	0006352	biological_process	DNA-templated transcription initiation
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006915	biological_process	apoptotic process
I	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
I	0017162	molecular_function	aryl hydrocarbon receptor binding
I	0032991	cellular_component	protein-containing complex
I	0033276	cellular_component	transcription factor TFTC complex
I	0042789	biological_process	mRNA transcription by RNA polymerase II
I	0045786	biological_process	negative regulation of cell cycle
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0046695	cellular_component	SLIK (SAGA-like) complex
I	0046982	molecular_function	protein heterodimerization activity
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0071339	cellular_component	MLL1 complex
K	0001112	biological_process	DNA-templated transcription open complex formation
K	0001833	biological_process	inner cell mass cell proliferation
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005669	cellular_component	transcription factor TFIID complex
K	0005737	cellular_component	cytoplasm
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
K	0030154	biological_process	cell differentiation
K	0042789	biological_process	mRNA transcription by RNA polymerase II
K	0045598	biological_process	regulation of fat cell differentiation
K	0046982	molecular_function	protein heterodimerization activity
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0051457	biological_process	maintenance of protein location in nucleus
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0000124	cellular_component	SAGA complex
M	0000492	biological_process	box C/D snoRNP assembly
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0002039	molecular_function	p53 binding
M	0003677	molecular_function	DNA binding
M	0003713	molecular_function	transcription coactivator activity
M	0004402	molecular_function	histone acetyltransferase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005669	cellular_component	transcription factor TFIID complex
M	0006282	biological_process	regulation of DNA repair
M	0006338	biological_process	chromatin remodeling
M	0006352	biological_process	DNA-templated transcription initiation
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006974	biological_process	DNA damage response
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
M	0033276	cellular_component	transcription factor TFTC complex
M	0042789	biological_process	mRNA transcription by RNA polymerase II
M	0043066	biological_process	negative regulation of apoptotic process
M	0043484	biological_process	regulation of RNA splicing
M	0045893	biological_process	positive regulation of DNA-templated transcription
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046982	molecular_function	protein heterodimerization activity
M	0050821	biological_process	protein stabilization
M	0051117	molecular_function	ATPase binding
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0060760	biological_process	positive regulation of response to cytokine stimulus
M	0070555	biological_process	response to interleukin-1
M	0070742	molecular_function	C2H2 zinc finger domain binding
M	0070761	cellular_component	pre-snoRNP complex
M	0071339	cellular_component	MLL1 complex
M	0140297	molecular_function	DNA-binding transcription factor binding
M	1902065	biological_process	response to L-glutamate
M	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0000124	cellular_component	SAGA complex
O	0001673	cellular_component	male germ cell nucleus
O	0001701	biological_process	in utero embryonic development
O	0001756	biological_process	somitogenesis
O	0001889	biological_process	liver development
O	0001892	biological_process	embryonic placenta development
O	0003677	molecular_function	DNA binding
O	0004402	molecular_function	histone acetyltransferase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005669	cellular_component	transcription factor TFIID complex
O	0005737	cellular_component	cytoplasm
O	0006282	biological_process	regulation of DNA repair
O	0006338	biological_process	chromatin remodeling
O	0006352	biological_process	DNA-templated transcription initiation
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0006915	biological_process	apoptotic process
O	0010467	biological_process	gene expression
O	0010468	biological_process	regulation of gene expression
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0019899	molecular_function	enzyme binding
O	0030331	molecular_function	nuclear estrogen receptor binding
O	0033276	cellular_component	transcription factor TFTC complex
O	0035264	biological_process	multicellular organism growth
O	0036285	biological_process	SAGA complex assembly
O	0042789	biological_process	mRNA transcription by RNA polymerase II
O	0042802	molecular_function	identical protein binding
O	0043229	cellular_component	intracellular organelle
O	0043484	biological_process	regulation of RNA splicing
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0048371	biological_process	lateral mesodermal cell differentiation
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060173	biological_process	limb development
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0065003	biological_process	protein-containing complex assembly
O	0070063	molecular_function	RNA polymerase binding
O	0070365	biological_process	hepatocyte differentiation
O	0097550	cellular_component	transcription preinitiation complex
O	1905069	biological_process	allantois development
O	1990841	molecular_function	promoter-specific chromatin binding
R	0000124	cellular_component	SAGA complex
R	0003677	molecular_function	DNA binding
R	0003713	molecular_function	transcription coactivator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005669	cellular_component	transcription factor TFIID complex
R	0006282	biological_process	regulation of DNA repair
R	0006352	biological_process	DNA-templated transcription initiation
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
R	0017025	molecular_function	TBP-class protein binding
R	0033276	cellular_component	transcription factor TFTC complex
R	0042789	biological_process	mRNA transcription by RNA polymerase II
R	0043484	biological_process	regulation of RNA splicing
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046982	molecular_function	protein heterodimerization activity
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0140297	molecular_function	DNA-binding transcription factor binding

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGsaDrTVRLWDV

Chain	Residue	Details
G	VAL642-VAL656
G	LEU684-ILE698
G	LEU726-ALA740

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
R	THR43
B	SER1188

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
R	SER51
E	ARG435
B	SER1198

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
R	THR59
E	LYS595
E	LYS597
E	LYS605
E	LYS611
E	LYS621
E	LYS631
E	LYS658

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
R	LYS19
M	SER196

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
M	SER155

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
M	SER158

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
M	THR159
I	GLY599

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
M	THR161

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
M	THR164

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site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
M	THR178

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
M	SER181

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