Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MZB

Cryo-EM structure of phosphodiesterase 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0042622	cellular_component	photoreceptor outer segment membrane
A	0047555	molecular_function	3',5'-cyclic-GMP phosphodiesterase activity
A	0060041	biological_process	retina development in camera-type eye
A	0097381	cellular_component	photoreceptor disc membrane
A	0141162	biological_process	negative regulation of cAMP/PKA signal transduction
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
B	0005515	molecular_function	protein binding
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0016020	cellular_component	membrane
B	0042622	cellular_component	photoreceptor outer segment membrane
B	0043153	biological_process	entrainment of circadian clock by photoperiod
B	0047555	molecular_function	3',5'-cyclic-GMP phosphodiesterase activity
B	0060041	biological_process	retina development in camera-type eye
B	0097381	cellular_component	photoreceptor disc membrane
B	0141162	biological_process	negative regulation of cAMP/PKA signal transduction
C	0001750	cellular_component	photoreceptor outer segment
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0004857	molecular_function	enzyme inhibitor activity
C	0005515	molecular_function	protein binding
C	0007601	biological_process	visual perception
C	0008270	molecular_function	zinc ion binding
C	0030553	molecular_function	cGMP binding
C	0042622	cellular_component	photoreceptor outer segment membrane
C	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
C	0045745	biological_process	positive regulation of G protein-coupled receptor signaling pathway
C	0060090	molecular_function	molecular adaptor activity
C	0097381	cellular_component	photoreceptor disc membrane
D	0001750	cellular_component	photoreceptor outer segment
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0004857	molecular_function	enzyme inhibitor activity
D	0005515	molecular_function	protein binding
D	0007601	biological_process	visual perception
D	0008270	molecular_function	zinc ion binding
D	0030553	molecular_function	cGMP binding
D	0042622	cellular_component	photoreceptor outer segment membrane
D	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
D	0045745	biological_process	positive regulation of G protein-coupled receptor signaling pathway
D	0060090	molecular_function	molecular adaptor activity
D	0097381	cellular_component	photoreceptor disc membrane

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDIdHrGtnNlY

Chain	Residue	Details
A	HIS599-TYR610
B	HIS597-TYR608

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	333
Details	Domain: {"description":"GAF 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	398
Details	Domain: {"description":"GAF 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	666
Details	Domain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)