6MXY
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 1701 |
| Chain | Residue |
| A | LYS1582 |
| A | MET1584 |
| A | ALA1585 |
| A | HOH1840 |
| A | HOH1880 |
| A | HOH1904 |
| B | ALA1585 |
| B | PO41703 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 1702 |
| Chain | Residue |
| A | VAL1510 |
| A | LYS1514 |
| A | LYS1516 |
| A | ASP1526 |
| A | HOH1804 |
| B | LYS1563 |
| A | ARG1508 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue K6M B 1701 |
| Chain | Residue |
| A | TRP1495 |
| A | TYR1502 |
| A | ASP1520 |
| A | ASP1521 |
| A | MET1584 |
| B | TYR1502 |
| B | PHE1519 |
| B | ASP1521 |
| B | MET1584 |
| B | HOH1824 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 1702 |
| Chain | Residue |
| A | ARG1508 |
| A | LYS1516 |
| A | GLU1524 |
| A | HOH1815 |
| B | ARG1490 |
| B | ASP1536 |
| B | LYS1563 |
| B | ARG1583 |
| B | HOH1813 |
| B | HOH1828 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 1703 |
| Chain | Residue |
| A | TYR1569 |
| A | LYS1582 |
| A | PO41701 |
| A | HOH1880 |
| B | TYR1569 |
| B | LYS1582 |
| B | HOH1808 |
| B | HOH1852 |
| B | HOH1873 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 1704 |
| Chain | Residue |
| B | LYS1494 |
| B | SER1497 |
| B | LEU1528 |
| B | LYS1530 |
| B | ASP1531 |
| B | HOH1809 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 238 |
| Details | Region: {"description":"Tudor-like","evidences":[{"source":"PubMed","id":"17190600","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Region: {"description":"Interaction with dimethylated histone H4","evidences":[{"source":"PubMed","id":"17190600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
