Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MXC

Crystal structure of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with GMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000310	molecular_function	xanthine phosphoribosyltransferase activity
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0020015	cellular_component	glycosome
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0042301	molecular_function	phosphate ion binding
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0000310	molecular_function	xanthine phosphoribosyltransferase activity
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0020015	cellular_component	glycosome
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0042301	molecular_function	phosphate ion binding
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0000310	molecular_function	xanthine phosphoribosyltransferase activity
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006178	biological_process	guanine salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0020015	cellular_component	glycosome
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0042301	molecular_function	phosphate ion binding
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0000310	molecular_function	xanthine phosphoribosyltransferase activity
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006178	biological_process	guanine salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0020015	cellular_component	glycosome
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0042301	molecular_function	phosphate ion binding
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0000310	molecular_function	xanthine phosphoribosyltransferase activity
E	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006178	biological_process	guanine salvage
E	0016757	molecular_function	glycosyltransferase activity
E	0020015	cellular_component	glycosome
E	0032263	biological_process	GMP salvage
E	0032264	biological_process	IMP salvage
E	0042301	molecular_function	phosphate ion binding
E	0046100	biological_process	hypoxanthine metabolic process
E	0046872	molecular_function	metal ion binding
E	0052657	molecular_function	guanine phosphoribosyltransferase activity
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0000310	molecular_function	xanthine phosphoribosyltransferase activity
F	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006178	biological_process	guanine salvage
F	0016757	molecular_function	glycosyltransferase activity
F	0020015	cellular_component	glycosome
F	0032263	biological_process	GMP salvage
F	0032264	biological_process	IMP salvage
F	0042301	molecular_function	phosphate ion binding
F	0046100	biological_process	hypoxanthine metabolic process
F	0046872	molecular_function	metal ion binding
F	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue 5GP A 301

Chain	Residue
A	GLU147
A	ARG200
A	TYR201
A	VAL202
A	PHE207
A	GLU208
A	HOH403
A	HOH406
A	HOH480
A	HOH483
A	HOH516
A	ASP148
A	ILE149
A	ASP151
A	THR152
A	GLY153
A	ARG154
A	THR155
A	LYS180

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 302

Chain	Residue
A	VAL85
A	GLY88
A	SER89
A	GLU147
A	ASP148
A	HOH406

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 303

Chain	Residue
A	GLY88
A	GLU208
A	ARG214
A	HOH413
A	HOH545
A	HOH556

site_id	AC4
Number of Residues	18
Details	binding site for residue 5GP B 301

Chain	Residue
B	GLU147
B	ASP148
B	ILE149
B	ASP151
B	THR152
B	GLY153
B	ARG154
B	THR155
B	LYS180
B	ARG200
B	TYR201
B	VAL202
B	PHE207
B	GLU208
B	HOH412
B	HOH418
B	HOH420
B	HOH532

site_id	AC5
Number of Residues	3
Details	binding site for residue MG B 302

Chain	Residue
B	LYS87
B	HOH450
B	HOH467

site_id	AC6
Number of Residues	5
Details	binding site for residue MG B 303

Chain	Residue
B	VAL85
B	GLY88
B	SER89
B	GLU147
B	ASP148

site_id	AC7
Number of Residues	18
Details	binding site for residue 5GP C 301

Chain	Residue
C	ASP148
C	ILE149
C	ASP151
C	THR152
C	GLY153
C	ARG154
C	THR155
C	LYS180
C	ARG200
C	TYR201
C	VAL202
C	PHE207
C	GLU208
C	HOH415
C	HOH423
C	HOH428
C	HOH451
C	HOH482

site_id	AC8
Number of Residues	6
Details	binding site for residue MG C 302

Chain	Residue
C	VAL85
C	GLY88
C	SER89
C	GLU147
C	ASP148
C	HOH423

site_id	AC9
Number of Residues	19
Details	binding site for residue 5GP D 301

Chain	Residue
D	HOH542
D	GLU147
D	ASP148
D	ILE149
D	ASP151
D	THR152
D	GLY153
D	ARG154
D	THR155
D	LYS180
D	ARG200
D	TYR201
D	VAL202
D	PHE207
D	GLU208
D	HOH414
D	HOH421
D	HOH428
D	HOH446

site_id	AD1
Number of Residues	3
Details	binding site for residue MG D 302

Chain	Residue
D	HOH484
D	HOH525
D	HOH555

site_id	AD2
Number of Residues	7
Details	binding site for residue MG D 303

Chain	Residue
D	VAL85
D	GLY88
D	SER89
D	GLU147
D	ASP148
D	HOH414
D	HOH465

site_id	AD3
Number of Residues	19
Details	binding site for residue 5GP E 301

Chain	Residue
E	GLU147
E	ASP148
E	ILE149
E	ASP151
E	THR152
E	GLY153
E	ARG154
E	THR155
E	LYS180
E	ARG200
E	TYR201
E	VAL202
E	PHE207
E	GLU208
E	HOH423
E	HOH431
E	HOH435
E	HOH436
E	HOH552

site_id	AD4
Number of Residues	3
Details	binding site for residue MG E 302

Chain	Residue
E	LYS87
E	HOH519
E	HOH524

site_id	AD5
Number of Residues	5
Details	binding site for residue MG E 303

Chain	Residue
E	VAL85
E	GLY88
E	SER89
E	GLU147
E	ASP148

site_id	AD6
Number of Residues	19
Details	binding site for residue 5GP F 301

Chain	Residue
F	GLU147
F	ASP148
F	ILE149
F	ASP151
F	THR152
F	GLY153
F	ARG154
F	THR155
F	LYS180
F	ARG200
F	TYR201
F	VAL202
F	PHE207
F	GLU208
F	HOH410
F	HOH426
F	HOH453
F	HOH454
F	HOH456

site_id	AD7
Number of Residues	5
Details	binding site for residue MG F 302

Chain	Residue
F	LYS87
F	GLY88
F	HOH410
F	HOH511
F	HOH556

site_id	AD8
Number of Residues	5
Details	binding site for residue MG F 303

Chain	Residue
F	VAL85
F	GLY88
F	SER89
F	GLU147
F	ASP148

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)