6MXC
Crystal structure of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with GMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006178 | biological_process | guanine salvage |
| A | 0020015 | cellular_component | glycosome |
| A | 0031981 | cellular_component | nuclear lumen |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0042301 | molecular_function | phosphate ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006178 | biological_process | guanine salvage |
| B | 0020015 | cellular_component | glycosome |
| B | 0031981 | cellular_component | nuclear lumen |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0042301 | molecular_function | phosphate ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006178 | biological_process | guanine salvage |
| C | 0020015 | cellular_component | glycosome |
| C | 0031981 | cellular_component | nuclear lumen |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0042301 | molecular_function | phosphate ion binding |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006178 | biological_process | guanine salvage |
| D | 0020015 | cellular_component | glycosome |
| D | 0031981 | cellular_component | nuclear lumen |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0042301 | molecular_function | phosphate ion binding |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| E | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006178 | biological_process | guanine salvage |
| E | 0020015 | cellular_component | glycosome |
| E | 0031981 | cellular_component | nuclear lumen |
| E | 0032263 | biological_process | GMP salvage |
| E | 0032264 | biological_process | IMP salvage |
| E | 0042301 | molecular_function | phosphate ion binding |
| E | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| F | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006178 | biological_process | guanine salvage |
| F | 0020015 | cellular_component | glycosome |
| F | 0031981 | cellular_component | nuclear lumen |
| F | 0032263 | biological_process | GMP salvage |
| F | 0032264 | biological_process | IMP salvage |
| F | 0042301 | molecular_function | phosphate ion binding |
| F | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 5GP A 301 |
| Chain | Residue |
| A | GLU147 |
| A | ARG200 |
| A | TYR201 |
| A | VAL202 |
| A | PHE207 |
| A | GLU208 |
| A | HOH403 |
| A | HOH406 |
| A | HOH480 |
| A | HOH483 |
| A | HOH516 |
| A | ASP148 |
| A | ILE149 |
| A | ASP151 |
| A | THR152 |
| A | GLY153 |
| A | ARG154 |
| A | THR155 |
| A | LYS180 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | VAL85 |
| A | GLY88 |
| A | SER89 |
| A | GLU147 |
| A | ASP148 |
| A | HOH406 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | GLY88 |
| A | GLU208 |
| A | ARG214 |
| A | HOH413 |
| A | HOH545 |
| A | HOH556 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue 5GP B 301 |
| Chain | Residue |
| B | GLU147 |
| B | ASP148 |
| B | ILE149 |
| B | ASP151 |
| B | THR152 |
| B | GLY153 |
| B | ARG154 |
| B | THR155 |
| B | LYS180 |
| B | ARG200 |
| B | TYR201 |
| B | VAL202 |
| B | PHE207 |
| B | GLU208 |
| B | HOH412 |
| B | HOH418 |
| B | HOH420 |
| B | HOH532 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| B | LYS87 |
| B | HOH450 |
| B | HOH467 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 303 |
| Chain | Residue |
| B | VAL85 |
| B | GLY88 |
| B | SER89 |
| B | GLU147 |
| B | ASP148 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue 5GP C 301 |
| Chain | Residue |
| C | ASP148 |
| C | ILE149 |
| C | ASP151 |
| C | THR152 |
| C | GLY153 |
| C | ARG154 |
| C | THR155 |
| C | LYS180 |
| C | ARG200 |
| C | TYR201 |
| C | VAL202 |
| C | PHE207 |
| C | GLU208 |
| C | HOH415 |
| C | HOH423 |
| C | HOH428 |
| C | HOH451 |
| C | HOH482 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 302 |
| Chain | Residue |
| C | VAL85 |
| C | GLY88 |
| C | SER89 |
| C | GLU147 |
| C | ASP148 |
| C | HOH423 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residue 5GP D 301 |
| Chain | Residue |
| D | HOH542 |
| D | GLU147 |
| D | ASP148 |
| D | ILE149 |
| D | ASP151 |
| D | THR152 |
| D | GLY153 |
| D | ARG154 |
| D | THR155 |
| D | LYS180 |
| D | ARG200 |
| D | TYR201 |
| D | VAL202 |
| D | PHE207 |
| D | GLU208 |
| D | HOH414 |
| D | HOH421 |
| D | HOH428 |
| D | HOH446 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 302 |
| Chain | Residue |
| D | HOH484 |
| D | HOH525 |
| D | HOH555 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 303 |
| Chain | Residue |
| D | VAL85 |
| D | GLY88 |
| D | SER89 |
| D | GLU147 |
| D | ASP148 |
| D | HOH414 |
| D | HOH465 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for residue 5GP E 301 |
| Chain | Residue |
| E | GLU147 |
| E | ASP148 |
| E | ILE149 |
| E | ASP151 |
| E | THR152 |
| E | GLY153 |
| E | ARG154 |
| E | THR155 |
| E | LYS180 |
| E | ARG200 |
| E | TYR201 |
| E | VAL202 |
| E | PHE207 |
| E | GLU208 |
| E | HOH423 |
| E | HOH431 |
| E | HOH435 |
| E | HOH436 |
| E | HOH552 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 302 |
| Chain | Residue |
| E | LYS87 |
| E | HOH519 |
| E | HOH524 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MG E 303 |
| Chain | Residue |
| E | VAL85 |
| E | GLY88 |
| E | SER89 |
| E | GLU147 |
| E | ASP148 |
| site_id | AD6 |
| Number of Residues | 19 |
| Details | binding site for residue 5GP F 301 |
| Chain | Residue |
| F | GLU147 |
| F | ASP148 |
| F | ILE149 |
| F | ASP151 |
| F | THR152 |
| F | GLY153 |
| F | ARG154 |
| F | THR155 |
| F | LYS180 |
| F | ARG200 |
| F | TYR201 |
| F | VAL202 |
| F | PHE207 |
| F | GLU208 |
| F | HOH410 |
| F | HOH426 |
| F | HOH453 |
| F | HOH454 |
| F | HOH456 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MG F 302 |
| Chain | Residue |
| F | LYS87 |
| F | GLY88 |
| F | HOH410 |
| F | HOH511 |
| F | HOH556 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MG F 303 |
| Chain | Residue |
| F | VAL85 |
| F | GLY88 |
| F | SER89 |
| F | GLU147 |
| F | ASP148 |
