6MX0
Crystal structure of human STING apoprotein (G230A, H232R, R293Q)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| B | ASP205 |
| B | GLU316 |
| B | ALA318 |
| B | ASP320 |
| B | HOH519 |
| B | HOH556 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"32926474","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28763789","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36972172","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
