6MVW
NavAb voltage-gated sodium channel, I217C/F203W
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| C | 0001518 | cellular_component | voltage-gated sodium channel complex |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005248 | molecular_function | voltage-gated sodium channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098655 | biological_process | monoatomic cation transmembrane transport |
| D | 0001518 | cellular_component | voltage-gated sodium channel complex |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005248 | molecular_function | voltage-gated sodium channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 A 1301 |
| Chain | Residue |
| A | LEU1151 |
| A | ARG1155 |
| A | VAL1190 |
| A | TYR1191 |
| A | TYR1193 |
| D | ILE2097 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PX4 A 1302 |
| Chain | Residue |
| B | PX42301 |
| A | LEU1031 |
| A | SER1034 |
| B | THR2162 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue PX4 A 1303 |
| Chain | Residue |
| A | TYR1142 |
| A | THR1162 |
| A | LEU1163 |
| A | GLY1164 |
| B | PX42303 |
| D | VAL2023 |
| D | GLY2026 |
| D | ILE2027 |
| D | GLY2030 |
| D | SER2034 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 1304 |
| Chain | Residue |
| A | PRO1075 |
| A | TRP1076 |
| A | SER1121 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue PX4 B 2301 |
| Chain | Residue |
| A | PX41302 |
| B | MET2137 |
| B | THR2138 |
| B | PHE2141 |
| B | THR2162 |
| B | GLY2164 |
| B | GLU2165 |
| B | PHE2167 |
| B | TYR2168 |
| B | PHE2171 |
| C | PRO1192 |
| C | TRP1195 |
| C | TRP1203 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PX4 B 2302 |
| Chain | Residue |
| A | ILE1097 |
| B | LEU2151 |
| B | TYR2191 |
| B | TYR2193 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue PX4 B 2303 |
| Chain | Residue |
| A | MET1137 |
| A | PHE1141 |
| A | GLY1164 |
| A | GLU1165 |
| A | PHE1167 |
| A | TYR1168 |
| A | PHE1171 |
| A | MET1174 |
| A | PX41303 |
| B | MET2188 |
| B | PRO2192 |
| B | TRP2195 |
| B | ILE2199 |
| B | TRP2203 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 2304 |
| Chain | Residue |
| B | SER2034 |
| B | LYS2035 |
| B | THR2036 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue PX4 C 1301 |
| Chain | Residue |
| C | VAL1023 |
| C | GLY1026 |
| C | ILE1027 |
| C | GLY1030 |
| C | LEU1031 |
| C | THR1033 |
| C | SER1034 |
| D | THR2138 |
| D | TYR2142 |
| D | THR2162 |
| D | LEU2163 |
| D | GLY2164 |
| D | PX42301 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue PX4 C 1302 |
| Chain | Residue |
| C | MET1137 |
| C | THR1138 |
| C | PHE1141 |
| C | GLY1164 |
| C | GLU1165 |
| C | PHE1167 |
| D | MET2188 |
| D | TRP2195 |
| D | TRP2203 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 C 1303 |
| Chain | Residue |
| C | TYR1191 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 C 1304 |
| Chain | Residue |
| C | TRP1076 |
| C | SER1121 |
| C | ILE1124 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue PX4 D 2301 |
| Chain | Residue |
| A | PRO1192 |
| A | TRP1195 |
| A | TRP1203 |
| C | PX41301 |
| D | MET2137 |
| D | GLY2164 |
| D | GLU2165 |
| D | PHE2167 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 D 2302 |
| Chain | Residue |
| D | PHE2152 |
| D | ARG2155 |
| D | PRO2192 |
| D | TYR2193 |
| D | ALA2194 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 D 2304 |
| Chain | Residue |
| D | PRO2128 |
| D | SER2132 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 D 2305 |
| Chain | Residue |
| D | GLN2115 |
| D | MET2116 |
| A | LEU1131 |
