6MVW

NavAb voltage-gated sodium channel, I217C/F203W

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0086010	biological_process	membrane depolarization during action potential
B	0001518	cellular_component	voltage-gated sodium channel complex
B	0005216	molecular_function	monoatomic ion channel activity
B	0005248	molecular_function	voltage-gated sodium channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0086010	biological_process	membrane depolarization during action potential
C	0001518	cellular_component	voltage-gated sodium channel complex
C	0005216	molecular_function	monoatomic ion channel activity
C	0005248	molecular_function	voltage-gated sodium channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0086010	biological_process	membrane depolarization during action potential
D	0001518	cellular_component	voltage-gated sodium channel complex
D	0005216	molecular_function	monoatomic ion channel activity
D	0005248	molecular_function	voltage-gated sodium channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0086010	biological_process	membrane depolarization during action potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PX4 A 1301

Chain	Residue
A	LEU1151
A	ARG1155
A	VAL1190
A	TYR1191
A	TYR1193
D	ILE2097

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PX4 A 1302

Chain	Residue
B	PX42301
A	LEU1031
A	SER1034
B	THR2162

---

site_id	AC3
Number of Residues	10
Details	binding site for residue PX4 A 1303

Chain	Residue
A	TYR1142
A	THR1162
A	LEU1163
A	GLY1164
B	PX42303
D	VAL2023
D	GLY2026
D	ILE2027
D	GLY2030
D	SER2034

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 1304

Chain	Residue
A	PRO1075
A	TRP1076
A	SER1121

---

site_id	AC5
Number of Residues	13
Details	binding site for residue PX4 B 2301

Chain	Residue
A	PX41302
B	MET2137
B	THR2138
B	PHE2141
B	THR2162
B	GLY2164
B	GLU2165
B	PHE2167
B	TYR2168
B	PHE2171
C	PRO1192
C	TRP1195
C	TRP1203

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PX4 B 2302

Chain	Residue
A	ILE1097
B	LEU2151
B	TYR2191
B	TYR2193

---

site_id	AC7
Number of Residues	14
Details	binding site for residue PX4 B 2303

Chain	Residue
A	MET1137
A	PHE1141
A	GLY1164
A	GLU1165
A	PHE1167
A	TYR1168
A	PHE1171
A	MET1174
A	PX41303
B	MET2188
B	PRO2192
B	TRP2195
B	ILE2199
B	TRP2203

---

site_id	AC8
Number of Residues	3
Details	binding site for residue PO4 B 2304

Chain	Residue
B	SER2034
B	LYS2035
B	THR2036

---

site_id	AC9
Number of Residues	13
Details	binding site for residue PX4 C 1301

Chain	Residue
C	VAL1023
C	GLY1026
C	ILE1027
C	GLY1030
C	LEU1031
C	THR1033
C	SER1034
D	THR2138
D	TYR2142
D	THR2162
D	LEU2163
D	GLY2164
D	PX42301

---

site_id	AD1
Number of Residues	9
Details	binding site for residue PX4 C 1302

Chain	Residue
C	MET1137
C	THR1138
C	PHE1141
C	GLY1164
C	GLU1165
C	PHE1167
D	MET2188
D	TRP2195
D	TRP2203

---

site_id	AD2
Number of Residues	1
Details	binding site for residue PO4 C 1303

Chain	Residue
C	TYR1191

---

site_id	AD3
Number of Residues	3
Details	binding site for residue PO4 C 1304

Chain	Residue
C	TRP1076
C	SER1121
C	ILE1124

---

site_id	AD4
Number of Residues	8
Details	binding site for residue PX4 D 2301

Chain	Residue
A	PRO1192
A	TRP1195
A	TRP1203
C	PX41301
D	MET2137
D	GLY2164
D	GLU2165
D	PHE2167

---

site_id	AD5
Number of Residues	5
Details	binding site for residue PX4 D 2302

Chain	Residue
D	PHE2152
D	ARG2155
D	PRO2192
D	TYR2193
D	ALA2194

---

site_id	AD6
Number of Residues	2
Details	binding site for residue PO4 D 2304

Chain	Residue
D	PRO2128
D	SER2132

---

site_id	AD7
Number of Residues	3
Details	binding site for residue PO4 D 2305

Chain	Residue
D	GLN2115
D	MET2116
A	LEU1131

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