6MV7

Crystal structure of RNAse 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004519	molecular_function	endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0006401	biological_process	RNA catabolic process
A	0006952	biological_process	defense response
A	0019731	biological_process	antibacterial humoral response
A	0031410	cellular_component	cytoplasmic vesicle
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051607	biological_process	defense response to virus
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue AMP A 201

Chain	Residue
A	LYS7
A	VAL121
A	HIS122
A	HOH319
A	VAL61
A	CYS62
A	ASN64
A	ARG66
A	HIS67
A	ASN68
A	ALA105
A	ASP107

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Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKhqNTF

Chain	Residue	Details
A	CYS37-PHE43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q64438

Chain	Residue	Details
A	HIS15

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q64438

Chain	Residue	Details
A	HIS122

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS38
A	LYS63
A	ARG82

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for bactericidal activity, bacterial agglutination activity and binding to bacterial lipopolysaccharide (LPS) => ECO:0000269|PubMed:27089320

Chain	Residue	Details
A	TRP1
A	ILE13

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Facilitates cleavage of polynucleotide substrates => ECO:0000269|PubMed:27013146

Chain	Residue	Details
A	HIS36

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Critical for catalytic activity => ECO:0000250|UniProtKB:Q9H1E1

Chain	Residue	Details
A	LYS38

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN32
A	ASN77

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