Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MQT

HRAS G12S in complex with GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue GDP A 201

Chain	Residue
A	GLY13
A	TYR32
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG202
A	HOH326
A	VAL14
A	HOH330
A	HOH332
A	HOH346
A	HOH347
A	HOH362
A	HOH400
A	HOH404
A	HOH426
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29
A	ASP30

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	GDP201
A	HOH326
A	HOH332
A	HOH347
A	HOH379

site_id	AC3
Number of Residues	25
Details	binding site for residue GDP B 201

Chain	Residue
B	GLY13
B	VAL14
B	GLY15
B	LYS16
B	SER17
B	ALA18
B	PHE28
B	VAL29
B	ASP30
B	TYR32
B	ASN116
B	LYS117
B	ASP119
B	LEU120
B	SER145
B	ALA146
B	LYS147
B	MG202
B	HOH318
B	HOH326
B	HOH327
B	HOH345
B	HOH355
B	HOH380
B	HOH392

site_id	AC4
Number of Residues	6
Details	binding site for residue MG B 202

Chain	Residue
B	SER17
B	GDP201
B	HOH309
B	HOH318
B	HOH326
B	HOH343

site_id	AC5
Number of Residues	25
Details	binding site for residue GDP C 201

Chain	Residue
C	GLY13
C	VAL14
C	GLY15
C	LYS16
C	SER17
C	ALA18
C	PHE28
C	VAL29
C	ASP30
C	TYR32
C	ASN116
C	LYS117
C	ASP119
C	LEU120
C	SER145
C	ALA146
C	LYS147
C	MG202
C	HOH306
C	HOH315
C	HOH324
C	HOH333
C	HOH350
C	HOH378
C	HOH389

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 202

Chain	Residue
C	SER17
C	GDP201
C	HOH306
C	HOH307
C	HOH315
C	HOH332

site_id	AC7
Number of Residues	26
Details	binding site for residue GDP D 201

Chain	Residue
D	SER17
D	ALA18
D	PHE28
D	VAL29
D	ASP30
D	TYR32
D	ASN116
D	LYS117
D	ASP119
D	LEU120
D	SER145
D	ALA146
D	LYS147
D	MG202
D	HOH314
D	HOH328
D	HOH332
D	HOH337
D	HOH347
D	HOH350
D	HOH373
D	HOH415
D	GLY13
D	VAL14
D	GLY15
D	LYS16

site_id	AC8
Number of Residues	6
Details	binding site for residue MG D 202

Chain	Residue
D	SER17
D	GDP201
D	HOH332
D	HOH337
D	HOH350
D	HOH359

site_id	AC9
Number of Residues	25
Details	binding site for residue GDP E 201

Chain	Residue
E	GLY13
E	VAL14
E	GLY15
E	LYS16
E	SER17
E	ALA18
E	PHE28
E	VAL29
E	ASP30
E	ASN116
E	LYS117
E	ASP119
E	LEU120
E	SER145
E	ALA146
E	LYS147
E	MG202
E	HOH322
E	HOH325
E	HOH334
E	HOH335
E	HOH336
E	HOH345
E	HOH387
E	HOH426

site_id	AD1
Number of Residues	6
Details	binding site for residue MG E 202

Chain	Residue
E	SER17
E	GDP201
E	HOH325
E	HOH335
E	HOH336
E	HOH366

site_id	AD2
Number of Residues	27
Details	binding site for residue GDP F 201

Chain	Residue
E	ARG73
F	GLY13
F	VAL14
F	GLY15
F	LYS16
F	SER17
F	ALA18
F	PHE28
F	VAL29
F	ASP30
F	ASN116
F	LYS117
F	ASP119
F	LEU120
F	SER145
F	ALA146
F	LYS147
F	MG202
F	HOH322
F	HOH331
F	HOH336
F	HOH346
F	HOH351
F	HOH371
F	HOH392
F	HOH402
F	HOH418

site_id	AD3
Number of Residues	6
Details	binding site for residue MG F 202

Chain	Residue
F	SER17
F	GDP201
F	HOH322
F	HOH336
F	HOH346
F	HOH362

site_id	AD4
Number of Residues	25
Details	binding site for residue GDP G 201

Chain	Residue
G	GLY13
G	VAL14
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	PHE28
G	VAL29
G	ASP30
G	ASN116
G	LYS117
G	ASP119
G	LEU120
G	SER145
G	ALA146
G	LYS147
G	MG202
G	HOH326
G	HOH327
G	HOH336
G	HOH337
G	HOH354
G	HOH364
G	HOH372
G	HOH379

site_id	AD5
Number of Residues	6
Details	binding site for residue MG G 202

Chain	Residue
G	SER17
G	GDP201
G	HOH327
G	HOH336
G	HOH337
G	HOH351

site_id	AD6
Number of Residues	25
Details	binding site for residue GDP H 201

Chain	Residue
H	GLY13
H	VAL14
H	GLY15
H	LYS16
H	SER17
H	ALA18
H	PHE28
H	VAL29
H	ASP30
H	ASN116
H	LYS117
H	ASP119
H	LEU120
H	SER145
H	ALA146
H	LYS147
H	MG202
H	HOH610
H	HOH614
H	HOH617
H	HOH639
H	HOH640
H	HOH647
H	HOH656
H	HOH660

site_id	AD7
Number of Residues	6
Details	binding site for residue MG H 202

Chain	Residue
H	SER17
H	GDP201
H	HOH614
H	HOH616
H	HOH617
H	HOH628

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	136
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)